Gut Microbes,
Journal Year:
2022,
Volume and Issue:
14(1)
Published: Aug. 24, 2022
The
association
between
the
physio-pathological
variables
of
type
2
diabetes
(T2D)
and
gut
microbiota
composition
suggests
a
new
avenue
to
track
disease
improve
outcomes
pharmacological
non-pharmacological
treatments.
This
enterprise
requires
strategies
elucidate
metabolic
disturbances
occurring
in
microbiome
as
progresses.
To
this
end,
physiological
knowledge
systems
biology
pave
way
for
characterizing
identifying
move
toward
healthy
compositions.
Here,
we
dissect
recent
associations
T2D.
In
addition,
discuss
advances
how
drugs,
diet,
exercise
modulate
favor
stages.
Finally,
present
computational
approaches
disentangling
activity
underlying
host-microbiota
codependence.
Altogether,
envision
that
combination
physiology
modeling
metabolism
will
drive
us
optimize
diagnosis
treatment
T2D
patients
personalized
way.
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(22), P. 8664 - 8664
Published: Nov. 17, 2020
Irritable
bowel
syndrome
(IBS)
is
one
of
the
most
prevalent
functional
gastrointestinal
disorders,
and
accumulating
evidence
gained
in
both
preclinical
clinical
studies
indicate
involvement
enteric
microbiota
its
pathogenesis.
Gut
resident
appear
to
influence
brain
activity
through
nervous
system,
while
their
composition
function
are
affected
by
central
system.
Based
on
these
results,
term
"brain-gut-microbiome
axis"
has
been
proposed
have
become
a
potential
therapeutic
target
IBS
cases.
However,
details
regarding
microbe-related
pathophysiology
remain
elusive.
This
review
summarizes
existing
knowledge
molecular
mechanisms
pathogenesis
as
well
recent
progress
related
microbiome-derived
neurotransmitters,
compounds,
metabolites,
neuroendocrine
factors,
enzymes.
Current Opinion in Systems Biology,
Journal Year:
2021,
Volume and Issue:
27, P. 100346 - 100346
Published: May 21, 2021
Microbial
communities
are
near
universally
present
in
nature.
A
wealth
of
meta-omics
data
has
been
gathered
from
numerous
ecosystems,
such
as
the
human
gut,
ocean
or
soil.
Constraint-based
reconstruction
and
analysis
is
a
valuable
tool
for
contextualisation
allows
mechanistic
prediction
metabolic
fluxes.
Advances
genome-scale
multispecies
modelling
tools
have
enabled
construction
interrogation
constraint-based
models
on
microbiome
scale
spanning
hundreds
organisms.
Here,
we
give
comprehensive
overview
areas
application
these
multiscale,
strain-
molecule-resolved
models,
discuss
key
works,
which
computational
yielded
novel
biological
knowledge.
We
show
that
can
complement
experimental
approaches
applications
ecology,
health,
industry
to
environmental
conservation.
Cell Death Discovery,
Journal Year:
2022,
Volume and Issue:
8(1)
Published: July 22, 2022
Lipid
peroxidation-induced
ferroptosis
is
a
newly
recognized
type
of
programmed
cell
death.
With
the
method
RNA
sequencing,
we
found
that
irradiation
(IR)
markedly
increased
expression
promotive
genes,
whereas
reduced
suppressive
genes
in
murine
intestine
tissues,
when
compared
with
those
liver
and
lung
tissues.
By
using
inducer
RSL-3
inhibitor
liproxstatin-1,
essential
for
IR-induced
intestinal
injury.
Acyl-CoA
Synthetase
Long-Chain
Family
Member
4
(ACSL4)
an
important
component
execution,
ACSL4
was
significantly
upregulated
irradiated
but
not
or
Antibacterial
antifungal
regents
ASCL4
protected
against
tissue
injury
Further
studies
showed
troglitazone,
inhibitor,
succeeded
to
suppresses
lipid
peroxidation
damage
after
IR.
Reproduction,
Journal Year:
2022,
Volume and Issue:
163(5), P. R81 - R96
Published: Feb. 23, 2022
Microbiome
or
microbiota
is
essential
to
regulate
many
mammalian
physiological
processes,
including
reproduction.
Like
other
organs
tissues,
the
upper
female
reproductive
tract
used
be
considered
as
devoid
of
microorganisms;
however,
a
non-infection-related
bacterial
community
was
discovered
in
uterus
from
humans
and
mammals,
its
composition
related
success.
The
dysbiosis
endometrial
associated
with
benign
malign
uterine
diseases.
Hence,
this
review
addressed
current
knowledge
about
alterations
their
association
common
diseases,
polyposis,
endometriosis,
myomatosis,
hyperplasia,
cancer.
There
specific
endometrium
most-analyzed
However,
constant
finding
consists
reduced
abundance
Firmicutes
Lactobacillus
,
while
there
an
increased
Proteobacteria
(such
Escherichia
coli
Enterococcus
),
Bacteroidetes
(
Prevotella
for
example),
Actinobacteria
(as
Gardnerella
contrast
healthy
endometrium.
Besides,
we
discussed
future
usefulness
components
biomarkers
diagnose
diseases
probable
clinical
outcomes.
In
addition,
analyzed
potential
use
probiotics
since
they
could
provide
alternative
complement
existing
therapies.
Gut Microbes,
Journal Year:
2022,
Volume and Issue:
14(1)
Published: Aug. 24, 2022
The
association
between
the
physio-pathological
variables
of
type
2
diabetes
(T2D)
and
gut
microbiota
composition
suggests
a
new
avenue
to
track
disease
improve
outcomes
pharmacological
non-pharmacological
treatments.
This
enterprise
requires
strategies
elucidate
metabolic
disturbances
occurring
in
microbiome
as
progresses.
To
this
end,
physiological
knowledge
systems
biology
pave
way
for
characterizing
identifying
move
toward
healthy
compositions.
Here,
we
dissect
recent
associations
T2D.
In
addition,
discuss
advances
how
drugs,
diet,
exercise
modulate
favor
stages.
Finally,
present
computational
approaches
disentangling
activity
underlying
host-microbiota
codependence.
Altogether,
envision
that
combination
physiology
modeling
metabolism
will
drive
us
optimize
diagnosis
treatment
T2D
patients
personalized
way.
