Bacterial hydrogen sulfide drives cryptic redox chemistry in gut microbial communities

Nature Metabolism, Journal Year: 2022, Volume and Issue: 4(10), P. 1260 - 1270

Published: Oct. 20, 2022

Language: Английский

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New Insights into the Relationship between Gut Microbiota and Radiotherapy for Cancer

Nutrients, Journal Year: 2022, Volume and Issue: 15(1), P. 48 - 48

Published: Dec. 22, 2022

Cancer is the second most common cause of death among humans in world, and threat that it presents to human health becoming more serious. The mechanisms cancer development have not yet been fully elucidated, new therapies are changing with each passing day. Evidence from literature has validated finding composition modification gut microbiota play an important role many different types cancer. results also demonstrate there a bidirectional interaction between radiotherapy treatments for In nutshell, modifications caused by effect on tumor radiosensitivity and, as result, affect efficacy show certain radiation toxicity, which leads numerous side effects. What research significance “gut-organ axis” formed may be one interesting potential mechanisms, although relevant still very limited. this review, we combine insights into relationship microbiota, cancer, radiotherapy. Based our current comprehensive understanding relationship, give overview based microbiota.

Language: Английский

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Sulfur-Element containing metabolic pathways in human health and crosstalk with the microbiome

Biochemistry and Biophysics Reports, Journal Year: 2023, Volume and Issue: 35, P. 101529 - 101529

Published: Aug. 13, 2023

In humans, methionine derived from dietary proteins is necessary for cellular homeostasis and regeneration of sulfur containing pathways, which produce inorganic species (ISS) along with essential organic compounds (OSC). recent years, have gained attention as key players in the crosstalk human health gut microbiome. Endogenously, ISS includes hydrogen sulfide (H2S), sulfite (SO32−), thiosulfate (S2O32−), sulfate (SO42−), are produced by enzymes transsulfuration oxidation pathways. Additionally, sulfate-reducing bacteria (SRB) lumen notable H2S producers can contribute to pools host. this review, we will focus on systemic effects biological describe contrasting mechanisms sulfurylation versus phosphorylation hydroxyl serine/threonine tyrosine residues post-translational modifications, role microbiome metabolism.

Language: Английский

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Digestive dynamics: Unveiling interplay between the gut microbiota and the liver in macronutrient metabolism and hepatic metabolic health

Physiological Reports, Journal Year: 2024, Volume and Issue: 12(12)

Published: June 1, 2024

Although the liver is largest metabolic organ in body, it not alone functionality and assisted by "an inside an organ," gut microbiota. This review attempts to shed light on partnership between microbiota metabolism of macronutrients (i.e., proteins, carbohydrates, lipids). All nutrients absorbed small intestines are delivered for further metabolism. Undigested food that enters colon metabolized produces secondary metabolites, which into portal circulation reach liver. These microbiota-derived metabolites co-metabolites include ammonia, hydrogen sulfide, short-chain fatty acids, bile trimethylamine N-oxide. Further, several compounds, such as acids can alter microbial composition, turn influence health. focuses these their host physiology. Furthermore, briefly delineates effect portosystemic shunt microbiota-liver axis, current understanding treatments target axis.

Language: Английский

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A review of BioTree construction in the context of information fusion: Priors, methods, applications and trends

Information Fusion, Journal Year: 2025, Volume and Issue: unknown, P. 103108 - 103108

Published: March 1, 2025

Language: Английский

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