Unravelling the vaginal microbiome, impact on health and disease

Current Opinion in Obstetrics & Gynecology, Journal Year: 2024, Volume and Issue: 36(5), P. 338 - 344

Published: July 15, 2024

Purpose of review The vaginal microbiome has a fundamental role in supporting optimal vaginal, reproductive, and sexual health. Conversely, dysbiosis the is linked to symptoms adverse health outcomes. This summarizes recent literature concerning disease, with focus on most common dysbiosis, bacterial vaginosis. Recent findings Molecular studies have expanded our understanding composition microbiome. Lactic acid-producing lactobacilli are an important component host defences against pathogens, whereas paucity associated sequelae. Bacterial vaginosis characterized by low levels increased nonoptimal anaerobes; however, exact cause remains unclear. Furthermore, despite decades research, recurrence rates following standard treatment unacceptably high. Strategies improve cure promote lactobacilli-dominated being investigated. Importantly, historical emerging evidence supports transmission vaginosis, which opens exciting opportunities for novel treatments that incorporate partners. Summary A mechanistic deeper disease needed inform ongoing development therapeutics cure. Partner holds promise improving

Language: Английский

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Affective symptoms in pregnancy are associated with the vaginal microbiome

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

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Microbial diversity and prediction function profiling of microbial communities in rose jam

Journal of Food Safety, Journal Year: 2024, Volume and Issue: 44(1)

Published: Jan. 24, 2024

Abstract The microbial diversity of rose jam was analyzed by high‐throughput sequencing, along with functional prediction the bacterial community. results indicate that Pseudomonas , Pantoea and Burkholderia emerged were top three dominant groups. Proteobacteria particularly abundant in R4 (99.1%) R6 (96.12%). Zygosaccharomyces unclassified fungi, Botrytis constituted fungal presence OTUs observed all samples, (52.36%), R8 (45.28), R9 samples (39.57%). Gene using PICRUSt revealed existence multiple KEGG modules associated human metabolism each sample. a high abundance genes indicated community's diverse wide range microgenetic resources can be further explored for research purposes. community found exhibits remarkable encompasses valuable information relevant to health.

Language: Английский

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Affective Symptoms in Pregnancy are Associated with the Vaginal Microbiome

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 12, 2024

ABSTRACT Composition of the vaginal microbiome in pregnancy is associated with adverse maternal, obstetric, and child health outcomes. Identifying sources individual differences therefore considerable clinical public interest. The current study tested hypothesis that composition during an individual’s experience affective symptoms stress exposure. Data were based on a prospective longitudinal diverse medically healthy community sample 275 mother-infant pairs. Affective exposure select measures biomarkers (diurnal salivary cortisol, serum sex hormones) collected at each trimester; self-report, clinical, medical records used to collect detailed data socio-demographic factors behavior, including diet sleep. Vaginal samples third trimester (34-40 weeks) characterized by 16S rRNA sequencing. Identified taxa clustered into three state types (CST1-3) dissimilarity microbiota composition. Results indicate depressive reliably CST3 trimester. Prediction functional potential from taxonomy revealed differential abundance metabolic pathways CST1-3 taxa, biosynthetic for neuroactive metabolites, serotonin dopamine. With exception bioavailable testosterone, no significant associations found between symptoms- stress-related CSTs. Our results provide further evidence how prenatal psychological distress alters maternal-fetal ecosystem may be important understanding maternal Importance Prenatal are outcomes, but mechanisms underlying these links their application intervention remain unclear. findings this investigation extend prior microbiome-oriented research demonstrating has biologically plausible mechanistic link also suggest additional applications assessment intervention.

Language: Английский

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Modern approaches to restoring vaginal microbiocenosis

Reproductive health of woman, Journal Year: 2024, Volume and Issue: 3, P. 53 - 59

Published: May 28, 2024

The article presents literary data on the morphology and types of vaginal lactobacilli, pathological changes in environment, as well modern possibilities restoring microflora a woman’s organism. Certain regularities regarding connection bacterial vaginosis with intestinal dysbiosis have been observed, which indicates single dysbiotic process organism dominant manifestation either sexual or digestive system.A review scientific publications recent years shows significant influence dysbiosis, infectious inflammatory diseases stomach intestines, oral use antibacterial drugs quantitative qualitative composition women. It was found that an increased number opportunistic microorganisms (85%) decreased lactobacilli bifidobacteria (less than 70%) intestine are associated rise content biota women reproductive system. This is explained by ability saprophytes to penetrate into organs increasing permeability mucous membrane wall, vascular bed, can be for example, background antibiotic use. cases leads closed circle, when need therapy eliminate one infection deepening other pathogens.Numerous studies demonstrated effectiveness selective decontamination (selective elimination pathogens) combination probiotic, prebiotic synbiotic restore microbiocenosis.Our experience using (1 capsule contains 5 billion colony-forming units Lactobacillus plantarum lyophilizate pcs. 8Р-AZ, fermentum 90Т-С4 inulin, once day 30 minutes before meal 7–10 days) complex non-pregnant age faster systemic restoration normal intravaginal flora. Thus, regression complaintsand normalization objective determined average 2.9 days versus 4.7 who were not administered drug.The obtained show containing lyophilized microbial mass probiotic lactobacteria, products their metabolism inulin (prebiotic) creates additional effect biocenosis immune mechanism ensuring colonization resistance body’s membranes.

Language: Английский

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