Neutral Polysaccharide from Platycodonis Radix-Ameliorated PM2.5-Induced Lung Injury by Inhibiting the TLR4/NF-κB p65 Pathway and Regulating the Lung and Gut Microbiome DOI

Yang Sun,

Yanchun Wang, Z.F. Yang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(50), P. 27923 - 27938

Published: Dec. 3, 2024

Platycodonis radix (PR) has been reported to play a protective role in lung injury. However, much less is known about the effect and mechanism of its main component PR polysaccharides (PRPs) particulate matter (PM2.5)-induced Here, neutral polysaccharide (MW: 244.56 kDa) was isolated from PR, mainly composed Rha, Ara, Gal, Glc, Xyl, Man. PRPs significantly improved PM2.5-induced pulmonary edema, oxidative damage, cell apoptosis downregulated inflammatory factor levels bronchoalveolar lavage fluid. Mechanistically, reduced intestinal mucosal barrier thereby lowering serum lipopolysaccharide inhibiting overactivation TLR4/NF-κB signaling pathway tissue. Notably, could optimize composition microbiota. Oral administration resulted enrichment short-chain fatty acid (SCFA)-producing bacteria, upregulating acetate, butyrate, isovalerate. Taken together, have great potential preventing repairing injury caused by PM2.5.

Language: Английский

Akkermansia muciniphila supplementation in patients with overweight/obese type 2 diabetes: Efficacy depends on its baseline levels in the gut DOI
Yifei Zhang, Ruixin Liu, Yufei Chen

et al.

Cell Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

2
Bronchoalveolar lavage fluid (BALF): Clinical applications for present and future DOI
Jie Mei, Yinong Chen, Huixiang Tian

et al.

The Innovation Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100115 - 100115

Published: Jan. 1, 2025

<p>Lungs are exposed to a wide range of complex internal and external environmental factors, creating pulmonary microenvironment that remains challenging detect interpret. Bronchoalveolar lavage fluid (BALF) contains an abundance cells, microorganisms, active substances, thus is considered be clinically promising body detection substance representative the microenvironment. The combination experimental strategies with emerging omics technologies has advanced identification interpretation microscopic components in BALF, underscoring its applications clinical detection. In summary, this review provides systematic overview development understanding discusses possible diagnosis, prediction, intervention, highlights role deciphering BALF.</p>

Language: Английский

Citations

0
The impact of environmental factors on respiratory tract microbiome and respiratory system diseases DOI Creative Commons
Ying Ge, Guo Tang,

Yawen Fu

et al.

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: April 4, 2025

Abstract The respiratory tract microbiome, a complex ecosystem of microorganisms colonizing the mucous layers and epithelial surfaces along with their associated microenvironment, plays vital role in maintaining function promoting maturation immune system. Current research suggests that environmental changes can disrupt microbiota, potentially leading to disease. This review summarizes existing on impact factors microbiome diseases, aiming offer new insights into prevention treatment

Language: Английский

Citations

0
IL-10 sensing by lung interstitial macrophages prevents bacterial dysbiosis-driven pulmonary inflammation and maintains immune homeostasis DOI
Seung Hyeon Kim,

Zachary White,

Anastasiia Gainullina

et al.

Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Intranasal administration of Clostridium butyricum and its derived extracellular vesicles alleviate LPS-induced acute lung injury DOI Creative Commons
Li Liu, Cihua Zheng, Zhenyang Xu

et al.

Microbiology Spectrum, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

ABSTRACT Acute lung injury (ALI) is associated with high morbidity and mortality rates. However, its clinical treatment limited. Currently, the of diseases by regulating microbiota has become a research hotspot. In this study, we investigated protective effects intranasal administration Clostridium butyricum derived extracellular vesicles (EVs) against lipopolysaccharide (LPS)-induced ALI. The results demonstrated that compared LPS group, pre-treatment group C. EVs reduced expression pro-inflammatory cytokines alleviated symptoms in ALI mice inhibiting TLR4/MyD88 signaling pathway. Moreover, inhibited apoptosis-related proteins increased barrier proteins. Additionally, intervention changed composition pulmonary microbiota. At species level, significantly relative abundance Acinetobacter johnsonii , while reversed effect. conclusion, these data demonstrate can prevent LPS-induced reducing inflammation, apoptosis, improving function. regulated to alleviate IMPORTANCE disorder plays an important role progression acute (ALI). very few studies have been conducted treat modulating diversity were altered mice, but ecological balance was restored . study reported mechanism for These reveal importance disease. It provides new approach new-generation probiotics.

Language: Английский

Citations

1
Advancements in omics technologies: Molecular mechanisms of acute lung injury and acute respiratory distress syndrome (Review) DOI

Zhihuan Zheng,

Xinyu Qiao,

Junhao Yin

et al.

International Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: 55(3)

Published: Dec. 27, 2024

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is an inflammatory response arising from and systemic with diverse causes associated high rates of morbidity mortality. To date, no fully effective pharmacological therapies have been established the relevant underlying mechanisms warrant elucidation, which may be facilitated by multi‑omics technology. The present review summarizes application technology in identifying novel diagnostic markers therapeutic strategies ALI/ARDS as well its pathogenesis.

Language: Английский

Citations

1
Neutral Polysaccharide from Platycodonis Radix-Ameliorated PM2.5-Induced Lung Injury by Inhibiting the TLR4/NF-κB p65 Pathway and Regulating the Lung and Gut Microbiome DOI

Yang Sun,

Yanchun Wang, Z.F. Yang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(50), P. 27923 - 27938

Published: Dec. 3, 2024

Platycodonis radix (PR) has been reported to play a protective role in lung injury. However, much less is known about the effect and mechanism of its main component PR polysaccharides (PRPs) particulate matter (PM2.5)-induced Here, neutral polysaccharide (MW: 244.56 kDa) was isolated from PR, mainly composed Rha, Ara, Gal, Glc, Xyl, Man. PRPs significantly improved PM2.5-induced pulmonary edema, oxidative damage, cell apoptosis downregulated inflammatory factor levels bronchoalveolar lavage fluid. Mechanistically, reduced intestinal mucosal barrier thereby lowering serum lipopolysaccharide inhibiting overactivation TLR4/NF-κB signaling pathway tissue. Notably, could optimize composition microbiota. Oral administration resulted enrichment short-chain fatty acid (SCFA)-producing bacteria, upregulating acetate, butyrate, isovalerate. Taken together, have great potential preventing repairing injury caused by PM2.5.

Language: Английский

Citations

0