New insights in amino sugar metabolism by the gut microbiome DOI Creative Commons
Wenqiang Shen, Jan Freark de Boer, Folkert Kuipers

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: May 25, 2025

Gut microorganisms inhabiting the intestinal tract play key roles in host's health and disease. A properly functioning gut microbiome requires availability of adequate carbon, nitrogen energy sources. One main sources for bacteria are glycans, which amino sugars important components. Amino a class carbohydrates one or more hydroxyl groups substituted with groups. However, bacterial utilization their impact on host have not been thoroughly assessed. In this review, we summarize latest discoveries about sugar metabolism by microbes, paying particular attention to N-acetyl-galactosamine (GalNAc), most abundant intestine, its potential implications microbial functionality health.

Language: Английский

Bacterial growth and environmental adaptation via thiamine biosynthesis and thiamine-mediated metabolic interactions DOI Creative Commons
Xihui Xu, Can Li,

Weimiao Cao

et al.

The ISME Journal, Journal Year: 2024, Volume and Issue: 18(1)

Published: Jan. 1, 2024

Abstract Understanding the ancestral transition from anaerobic to aerobic lifestyles is essential for comprehending life’s early evolution. However, biological adaptations occurring during this crucial remain largely unexplored. Thiamine an important cofactor involved in central carbon metabolism and respiration. Here, we explored phylogenetic global distribution of thiamine-auxotrophic thiamine-prototrophic bacteria based on thiamine biosynthetic pathway 154 838 bacterial genomes. We observed strong coincidences origin thiamine-synthetic with “Great Oxygenation Event,” indicating that biosynthesis emerged as adaptation Furthermore, demonstrated thiamine-mediated metabolic interactions are fundamental factors influencing assembly diversity communities by a survey across 4245 soil samples. Through our newly established stable isotope probing–metabolic modeling method, uncovered active utilization response changing environments, thus revealing environmental strategy employed at community level. Our study demonstrates widespread their roles setting stage evolutionary subsequent adaptation. These findings provide new insights into evolution growth environments.

Language: Английский

Citations

6
Microbial functional diversity and redundancy: moving forward DOI Creative Commons
Pierre Ramond, Pierre E. Galand, Ramiro Logares

et al.

FEMS Microbiology Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Microbial functional ecology is expanding as we can now measure the traits of wild microbes that affect ecosystem functioning. Here, review techniques and advances could be bedrock for a unified framework to study microbial functions. These include our newfound access environmental genomes, collections traits, but also ability microbes’ distribution expression. We then explore technical, ecological, evolutionary processes explain patterns diversity redundancy. Next, suggest reconciling microbiology with biodiversity-ecosystem-functioning studies by experimentally testing significance redundancy efficiency, resistance, resilience processes. Such will aid in identifying state shifts tipping points microbiomes, enhancing understanding how where microbiomes guide Earth's biomes context changing planet.

Language: Английский

Citations

5
Enhancing adaptive performance of thermoresponsive ionogel systems through redundancy-driven architecture DOI
Qianxi Zhou, Jianan Yao,

Youngjun Men

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163070 - 163070

Published: April 1, 2025

Language: Английский

Citations

0
Harmful algal blooms are preceded by a predictable and quantifiable shift in the oceanic microbiome DOI Creative Commons
Miranda C. Mudge, Michael Riffle, Gabriella Chebli

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 28, 2025

Harmful algal blooms (HABs) have become a worldwide environmental and human health problem, stressing the urgent need for reliable forecasting tool. Dynamic interactions between algae, including harmful bacteria play large role regulating water chemistry. Free-living quickly respond to small physical and/or chemical changes by adjusting their proteome. We hypothesize that this response is detectable at peptide level occurs before rapid phytoplankton growth characteristic of bloom events. To characterize microbiome's physiological preceding onset, we collected analyzed high-resolution metaproteomic time series free-living microbiome in coastal ecosystem. confirm twelve candidate HAB biomarkers are detectable, quantifiable, correlated across two pre-bloom periods. This study identifies proteomic shifts bacterial peptides which may be used as predictive initiation, potentially mitigating detrimental outcomes future.

Language: Английский

Citations

0
New insights in amino sugar metabolism by the gut microbiome DOI Creative Commons
Wenqiang Shen, Jan Freark de Boer, Folkert Kuipers

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: May 25, 2025

Gut microorganisms inhabiting the intestinal tract play key roles in host's health and disease. A properly functioning gut microbiome requires availability of adequate carbon, nitrogen energy sources. One main sources for bacteria are glycans, which amino sugars important components. Amino a class carbohydrates one or more hydroxyl groups substituted with groups. However, bacterial utilization their impact on host have not been thoroughly assessed. In this review, we summarize latest discoveries about sugar metabolism by microbes, paying particular attention to N-acetyl-galactosamine (GalNAc), most abundant intestine, its potential implications microbial functionality health.

Language: Английский

Citations

0