The virulence contribution of the CFEM family genes of Beauveria bassiana is closely influenced by the external iron environment DOI Creative Commons
Xu Zhang, Guang Wang, Bin Chen

et al.

Microbiology Spectrum, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

ABSTRACT The common in fungal extracellular membrane (CFEM) domain proteins represent characteristic proteins. entomopathogenic fungus Beauveria bassiana contains 12 CFEM involved the generation of iron hunger response. However, many BbCFEM genes that infect insects do not promote virulence. In this study, we systematically assessed role family virulence under moderate concentrations and severe starvation (0.4 mM BPS) induced by body wall infection injection infection. results showed members have different functions based on virulence, which is directly affected external levels. Quantitative real-time reverse-transcription polymerase chain reaction preliminarily demonstrated deletion significantly increased expression levels other members. compensated for gene damage BbMFEM genes. addition, participates initiation responses to cell stress oxidative stress. These findings reveal evolutionary strategies employed pathogenic fungi adapt environment population reproduction. This study expands our understanding mechanism infecting pests. IMPORTANCE a protein can trap heme, assists colonization. an widely used control We contribution B. ’s growth resistance found with starvation, also plays important provides new insights into genetic families mechanisms they

Language: Английский

The virulence contribution of the CFEM family genes of Beauveria bassiana is closely influenced by the external iron environment DOI Creative Commons
Xu Zhang, Guang Wang, Bin Chen

et al.

Microbiology Spectrum, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

ABSTRACT The common in fungal extracellular membrane (CFEM) domain proteins represent characteristic proteins. entomopathogenic fungus Beauveria bassiana contains 12 CFEM involved the generation of iron hunger response. However, many BbCFEM genes that infect insects do not promote virulence. In this study, we systematically assessed role family virulence under moderate concentrations and severe starvation (0.4 mM BPS) induced by body wall infection injection infection. results showed members have different functions based on virulence, which is directly affected external levels. Quantitative real-time reverse-transcription polymerase chain reaction preliminarily demonstrated deletion significantly increased expression levels other members. compensated for gene damage BbMFEM genes. addition, participates initiation responses to cell stress oxidative stress. These findings reveal evolutionary strategies employed pathogenic fungi adapt environment population reproduction. This study expands our understanding mechanism infecting pests. IMPORTANCE a protein can trap heme, assists colonization. an widely used control We contribution B. ’s growth resistance found with starvation, also plays important provides new insights into genetic families mechanisms they

Language: Английский

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