Therapeutic and protective approaches to combat Campylobacter jejuni infections DOI Creative Commons
Irshad Sharafutdinov, Bodo Linz, Nicole Tegtmeyer

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 6, 2025

Campylobacter jejuni is a typical zoonotic bacterium, colonizing the gut of many bird species as commensal. In humans, C. major foodborne pathogen. Infection humans causes campylobacteriosis in small intestine, constituting main source bacteria-dependent gastroenteritis cases worldwide. particular, ingestion under-cooked rooster meat, raw milk and contaminated water, well cross-contamination ready-to-eat food after handling chicken are responsible for majority infections. As consequence, infected individuals may acquire watery and/or bloody diarrhea associated with abdominal pain, eventually post-infection illnesses neural system joints, including Guillain-Barré, Miller Fisher Reiter syndromes. One therapeutic strategy to reduce colonization farms using vaccination, bacteriocins phage therapy protocols. Prevention approaches during poultry meat processing comprise compliance high hygiene standards. Furthermore, substantial progress has been also made recent years combat established mouse vitro cell model systems. this regard, specific colonization- pathogenicity-associated components were considered favored treatment structures, targeting bacterial movement, host interaction, intracellular survival, propagation spread bacteria. This complemented by number pharmaceutical compounds jejuni-induced epithelial damage, inflammation apoptosis mice. Here we review these novel prevention "One World - Health" that aim diminish consequences acute sequelae humans.

Language: Английский

Therapeutic and protective approaches to combat Campylobacter jejuni infections DOI Creative Commons
Irshad Sharafutdinov, Bodo Linz, Nicole Tegtmeyer

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 6, 2025

Campylobacter jejuni is a typical zoonotic bacterium, colonizing the gut of many bird species as commensal. In humans, C. major foodborne pathogen. Infection humans causes campylobacteriosis in small intestine, constituting main source bacteria-dependent gastroenteritis cases worldwide. particular, ingestion under-cooked rooster meat, raw milk and contaminated water, well cross-contamination ready-to-eat food after handling chicken are responsible for majority infections. As consequence, infected individuals may acquire watery and/or bloody diarrhea associated with abdominal pain, eventually post-infection illnesses neural system joints, including Guillain-Barré, Miller Fisher Reiter syndromes. One therapeutic strategy to reduce colonization farms using vaccination, bacteriocins phage therapy protocols. Prevention approaches during poultry meat processing comprise compliance high hygiene standards. Furthermore, substantial progress has been also made recent years combat established mouse vitro cell model systems. this regard, specific colonization- pathogenicity-associated components were considered favored treatment structures, targeting bacterial movement, host interaction, intracellular survival, propagation spread bacteria. This complemented by number pharmaceutical compounds jejuni-induced epithelial damage, inflammation apoptosis mice. Here we review these novel prevention "One World - Health" that aim diminish consequences acute sequelae humans.

Language: Английский

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