Thirty-year trends of depressive disorders in 204 countries and territories from 1990 to 2019: An age-period-cohort analysis

Psychiatry Research, Journal Year: 2023, Volume and Issue: 328, P. 115433 - 115433

Published: Aug. 27, 2023

Language: Английский

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Analysis of epidemiological trends and risk factors in high-risk areas for pulmonary tuberculosis: an observational longitudinal study in Xinjiang, China

BMJ Open, Journal Year: 2025, Volume and Issue: 15(2), P. e087413 - e087413

Published: Feb. 1, 2025

To explore the spatial and temporal variations in long-term risk of developing tuberculosis (TB) factors influencing it order to contribute goal eradicating TB. Observational longitudinal study. Xinjiang, China, 2005-2019. Comparison TB incidence across age, period, cohort space using socioeconomic (including gross domestic product per capita, population density, public budget revenue total retail sales consumer goods), health number hospital beds, technicians basic medical insurance for urban residents) environmental variables (PM2.5, mean air temperature, wind speed, relative humidity precipitation). The importance these pulmonary (PTB) is revealed by Q-value (0, 1), with larger values indicating that heterogeneity explanatory PTB more pronounced. All clinically diagnosed confirmed cases were collected. descriptive analysis included from 2005 2019, while various districts counties between 2011 2019 subjected further analysis. From a 642 332 reported an average annual rate 172/100 000. age presented bimodal distribution, namely 20-24 years elderly (>60 years). high prevalence was distributed southern part Xinjiang. Among had greater effect on PTB, lower GDP capita (Q-value=0.65) largest Xinjiang compared others (higher PM2.5: Q-value=0.56, personnel: Q-value=0.49, higher temperature: Q-value=0.47 residents' insurance: Q-value=0.46). main heterogeneous different regions. Furthermore, interactions among enhanced power regarding disease. Identifying high-risk groups, regions, will expand epidemiological knowledge areas potentially aid designing targeted interventions.

Language: Английский

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Further analysis of tuberculosis in eight high-burden countries based on the Global Burden of Disease Study 2021 data

Infectious Diseases of Poverty, Journal Year: 2024, Volume and Issue: 13(1)

Published: Sept. 30, 2024

Language: Английский

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Retrospective Analysis of the Efficacy and Safety of Endoscopic Spinal Tuberculosis Focus Removal versus Posterior Pedicle Lesion Removal, Bone Grafting, and Internal Fixation Combined with Drug Chemotherapy for Thoracolumbar Tuberculosis

Infection and Drug Resistance, Journal Year: 2024, Volume and Issue: Volume 17, P. 733 - 748

Published: Feb. 1, 2024

This study aims to investigate the clinical efficacy of endoscopic spinal tuberculosis focus removal, posterior pedicle lesion bone grafting, and internal fixation combined with drug chemotherapy in treating thoracolumbar tuberculosis. It also seeks summarize strategies for preventing complications provide a reference treatment. We retrospectively analyzed 105 patients treated our hospital from January 2018 December 2022. Patients were divided into two groups: Group A (n=38), who underwent B (n=67), fixation. All received preoperative quadruple anti-tuberculosis (Isoniazid, Rifampicin, Pyrazinamide, Ethambutol) 2-4 weeks. recorded compared parameters such as operation time, intraoperative blood loss, postoperative drainage, recovery stay, transfusion, complications. pre- lumbar VAS, ODI, erythrocyte sedimentation rate, C-reactive protein, Procalcitonin, D-Dimer, Neutrophil Lymphocyte ratio, hemoglobin, total Cobb angle evaluate kyphotic deformity correction. Preoperative data including age, sex, body mass index, segment involvement, past medical history, smoking VAS score, ODI Cobb's showed no significant difference between groups (P>0.05). Main indicators revealed that had significantly lower scores, higher hemoglobin protein levels, recurrence rate than at last follow-up (P<0.05). Secondary required less shorter operative hospitalization Angle Endoscopic removal can achieve comparable safety fixation, bleeding, drainage. method effectively improve sedimentation, function, restore angle, reduce pain, making it worthy promotion application.

Language: Английский

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Toward tuberculosis elimination by understanding epidemiologic characteristics and risk factors in Hainan Province, China

Infectious Diseases of Poverty, Journal Year: 2024, Volume and Issue: 13(1)

Published: Feb. 27, 2024

Abstract Background The disease burden of tuberculosis (TB) was heavy in Hainan Province, China, and the information on transmission patterns limited with few studies. This atudy aims to further explore epidemiological characteristics influencing factors TB thereby contribute valuable scientific evidences for elimination Province. Methods notification data Province from 2013 2022 were collected Chinese National Disease Control Information System Tuberculosis Surveillance System, along socio-economic data. spatial–temporal population distributions analyzed, spatial autocorrelation analysis conducted rate clustering. In addition, cases among in-country migrants described, delay pattern seeking medical care investigated. Finally, a geographically temporally weighted regression (GTWR) model adopted analyze relationship between indicators. tailored control suggestions different regions provided by understanding risk obtained GTWR. Results From 2022, 64,042 notified estimated annual percentage change 2020 − 6.88% [95% confidence interval ( CI ): 5.30%, 3.69%], higher rates central southern regions. majority patients males (76.33%) farmers (67.80%). Cases primarily originated Sichuan (369 cases), Heilongjiang (267 Hunan (236 Guangdong (174 Guangxi (139 accounting 53%. (98.83%) through passive case finding approaches, care. GTWR showed that gross domestic product per capita, number institutions health personnel 10,000 people main affecting high some Different regional measures such as more specialized hospitals proposed based each region. Conclusions has been declining overall but still remained Particular attention should be paid prevalence males, farmers, out-of-province migrant populations. also influenced economic development conditions, indicating need hospitals, active surveillance other prevention promote progress

Language: Английский

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Application of the age-period-cohort model in tuberculosis

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 29, 2025

Up to now, tuberculosis (TB) remains a global public health problem, posing serious threat human health. Traditional methods for analyzing time-varying trends, such as age and period, tend ignore the poor impact of birth cohorts, which is an important factor in development TB. The age-period-cohort (APC) model, statistical method widely used recent decades economics, sociology, epidemiology, can quantitatively estimate efficacy different age, cohort groups TB by separating effects these three dimensions controlling confounding factors among time variables. purpose this paper briefly review focus on application existing APC model field TB, explain its advantages disadvantages. This study will help provides theoretical basis reference using analysis prediction.

Language: Английский

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Association of urbanization-related factors with tuberculosis incidence among 1992 counties in China from 2005 to 2019: a nationwide observational study

Infectious Diseases of Poverty, Journal Year: 2025, Volume and Issue: 14(1)

Published: April 25, 2025

Abstract Background Most high tuberculosis (TB) burden countries are in low- and middle-income regions undergoing rapid urbanization. We aimed to assess the association between urbanization factors TB incidence China. Methods evaluated at county level China from 2005 2019 using a composite index integrating population density, gross domestic product (GDP, per capita), hospital beds 1000 population, nighttime light (NTL), normalized difference vegetation (NDVI). The annual rate number of cases were obtained national Tuberculosis Information Management System, maintained by Chinese Center for Disease Control Prevention. Fixed-effects models used examine incidence. A subgroup analysis was performed dividing counties into four regions: northeast, eastern, central, western. Results total 1992 included this study. Overall, scores associated with reduced (β = − 0.0114, P < 0.001), corresponding 1.1% reduction unit score. Quadratic presented U-shaped relationship an inflection point 52.94 units. For each indicator urbanization, density positively incidence, ratios 11.384 [95% confidence interval ( CI ): 9.337 13.881], 1.015 (95% : 1.011 1.019), respectively, while GDP, NTL, NDVI exhibited protective effects. Central displayed increase trend that score linked 1.8% rise Conclusions Urbanization-related factors, including NTL NDVI, inversely China’s contrasting results highlighted region-specific challenges. Therefore, governments developing should adopt integrated approaches promote both economic growth sustainable development environment during optimize control efforts. Graphical abstract

Language: Английский

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Trends in tuberculosis mortality among older adults in China, 2004–2021: a Joinpoint regression and age–period–cohort analysis

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 6, 2025

Tuberculosis (TB) remains a major public health problem in China and globally, particularly among older adults. This study aimed to examine secular trends TB mortality adults the net effects of age, period, cohort. Data from National Disease Surveillance Points (DSPs) system were analyzed using Joinpoint regression determine annual changes individuals aged 60 years 2004 2021. An age-period-cohort (APC) analysis intrinsic estimator (IE) method was conducted estimate independent The age-standardized rate 5.68 per 100,000, with higher rates observed men, rural areas, western regions. declined overall 2021, although decline has slowed recent years. APC revealed increased relative risk (RR) rising 0.57 60-64 age group 1.53 80-84 group. period effect decreased 2007 showing areas (RR = 1.51) than urban 1.16) during 2007-2011, but this trend reversed 2017-2021. cohort generally declined, exception certain demographic groups that showed an increase 1952-1956 1957-1961 birth cohorts. Variations highlight differences by gender, regions, providing insights for targeted intervention strategies.

Language: Английский

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Diagnostic value of third-generation nanopore sequencing in extrapulmonary tuberculosis

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 14

Published: Jan. 7, 2025

This study aimed to explore the accuracy of third-generation nanopore sequencing diagnose extrapulmonary tuberculosis (EPTB). Samples were collected from lesions 67 patients with suspected EPTB admitted between April 2022 and August 2023. Nanopore sequencing, acid-fast bacilli (AFB) staining, DNA testing, X-pert mycobacterial cultures performed. The sensitivity, specificity, positive predictive value (PPV), negative (NPV) area under receiver operating characteristic curve (AUC) calculated for different diagnostic methods, their accuracies compared. demonstrated highest correct diagnosis rate among 50 cases, independently diagnosing 19 cases missed by conventional methods. Its sensitivity (62.00%), specificity (94.10%), PPV (96.90%), NPV (45.70%) AUC (0.781, 95% CI: 0.67-0.89) superior those such as AFB X-pert, solid culture, indicating its significantly efficient advantage in detection. technology outperforms methods culture EPTB, promising improve EPTB.

Language: Английский

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Research on the effect of social capital on public tuberculosis prevention and control practices based on stimulus‒organism‒response theory

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Background The burden of tuberculosis has emerged as a significant challenge in the domain global public health, particularly developing nations. Hence, prevention and control TB are delayed. current study is based on SOR theory aims to explore how social capital affects practices. goal this investigation offer theoretical support practical guidance for future strategies aim ed at preventing controlling TB. Methods This employed multi-stage stratified random sampling method implement questionnaire survey combining online offline surveys 3179 participants. Based theory, chain mediation effect model knowledge reserves attitudes between practices was constructed empirically evaluated using SPSS27.0 software. Results findings suggest that positively contributes Both regarding act mediators Additionally, function together Conclusions To eliminate by 2030, government health organizations must actively promote efforts. Support from all sectors society essential. Public awareness through education reducing discrimination against patients crucial steps. scientific research needed identify more effective treatment methods increase cure rates reduce transmission. Achieving these objectives vital safeguarding reaching elimination.

Language: Английский

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