The current clinical approach to feeding and eating disorders aimed to increase personalization of management

World Psychiatry, Journal Year: 2025, Volume and Issue: 24(1), P. 4 - 31

Published: Jan. 15, 2025

Feeding and eating disorders (FEDs) are a heterogeneous grouping of at the mind-body interface, with typical onset from childhood into emerging adulthood. They occur along spectrum disordered compensatory weight management behaviors, low to high body weight. Psychiatric comorbidities norm. In contrast other major psychiatric disorders, first-line treatments for FEDs mainly psychological and/or nutrition-focused, medications playing minor adjunctive role. Patients, carers clinicians all have identified personalization treatment as priority. Yet, FEDs, evidence base supporting this is limited. Importantly, related behaviors can serious physical consequences may put patient's life risk. these cases, immediate safety risk considerations least period need be prioritized over efforts care. This paper systematically reviews several key domains that relevant characterization individual patient FED aimed management. These include symptom profile, clinical subtypes, severity, staging, complications consequences, antecedent concomitant conditions, social functioning quality life, neurocognition, cognition emotion, dysfunctional cognitive schemata, personality traits, family history, early environmental exposures, recent stigma, protective factors. Where possible, validated assessment measures use in practice identified. The limitations current pointed out, possible directions future research highlighted. also novel approaches providing more fine-grained sophisticated ways personalize such those utilize neurobiological markers. We additionally outline remote measurement technologies designed delineate patients' illness recovery trajectories facilitate development intervention approaches.

Language: Английский

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Trajectories and predictive factors of weight recovery in patients with anorexia nervosa completing treatment. A latent class mixed model approach

European Eating Disorders Review, Journal Year: 2024, Volume and Issue: 32(4), P. 758 - 770

Published: March 19, 2024

Abstract Background Treatment of anorexia nervosa (AN) sometimes requires hospitalisation, which is often lengthy, with little ability to predict individual trajectory. Depicting specific profiles treatment response and their clinical predictors could be beneficial tailor inpatient management. The aim this research was identify clusters weight recovery during treatment, predictors. Methods A sample 181 inpatients who completed a programme for AN included in retrospective study. latent class mixed model approach used distinct weight‐gain trajectories. Clinical variables were introduced multinomial logistic regression as the different classes. Results four‐class quadratic retained, able correctly classify 63.7% cohort. It encompassed late‐rising, flattening, moderate trajectory body mass index (BMI) increase (class 1), steady, high 2), an early‐rising, 3) 4). Significant belonging baseline BMI (all classes), illness duration benzodiazepine prescription 3). Conclusion Predicting kinetics based on routinely collected indicators improve clinician awareness patient engagement by enabling shared expectations response.

Language: Английский

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Prevalence of alcohol use and smoking in eating disorders: a systematic review and meta-analysis

Journal of Substance Use, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 20

Published: Jan. 5, 2025

Objectives The purpose of this study was a systematic review and meta-analysis the prevalence alcohol smoking in eating disorders.

Language: Английский

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Factors associated with probability of inpatient hospitalization in military-affiliated adolescents and young adults with eating disorders

Eating Disorders, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 20

Published: Feb. 21, 2025

This study examined demographic and military factors related to probability of hospitalization among military-affiliated adolescents young adults (AYA) with an eating disorder (ED) diagnosis. Participants were AYA (spouses not included), ages 10-26 years. De-identified data extracted from the Military Health System Data Repository 2016-2021. Kaplan-Meier risk estimates determined proportion participants a following their initial ED diagnosis across time. Cox proportional hazard models evaluated adjusted associations military-specific hospitalization. Of 7,705 diagnosis, approximately one in five (n = 1,569) had during period. Weight categories only recorded for 35% 2,675) participants. Adjusting other variables, was more likely for: 15-17 years old (versus age groups), females males), those underweight higher weights), who received care at civilian facilities directly within System), parent serving Navy Army). There no significant difference by Results indicate disparities EDs System. More research is needed understand access engagement ED-related healthcare AYA.

Language: Английский

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Mendelian randomization analyses uncover causal relationships between brain structural connectome and risk of psychiatric disorders

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Abstract Growing evidence suggests abnormalities of brain structural connectome in psychiatric disorders, but the causal relationships remain underexplored. We conducted bidirectional two-sample Mendelian randomization (MR) analyses to investigate links between 206 white-matter connectivity phenotypes (n = 26,333, UK Biobank) and 13 major disorders 14,307 1,222,882). Forward MR identified effects genetically predicted five on six with associations being significant or suggestive. For instance, left-hemisphere frontoparietal control network right-hemisphere default mode was significantly negatively associated autism spectrum disorder risk, while increased hippocampus linked decreased anorexia nervosa cannabis use risk. Reverse revealed suggestively risk two four different phenotypes. example, susceptibility found be visual pallidum. These findings offer new insights into etiology highlight potential biomarkers for early detection prevention at level.

Language: Английский

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The Medical Complications of Purging Behaviours Associated With Eating Disorders

European Eating Disorders Review, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

ABSTRACT Objective The purpose of this paper is to comprehensively review the medical complications associated with purging behaviours and their recommended treatments. Methods A thorough literature through May 2024 was completed. Results affect every body system. Some these are related method frequency while others independent purging. Conclusion Purging eating disorders confer serious that generally reversible cessation behaviours, weight restoration, treatment underlying disorder.

Language: Английский

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Dual Diagnosis

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

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Eating Disorders

Published: Jan. 1, 2025

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Eating disorders and later incidence of cancer – A nationwide longitudinal study in Denmark

Biological Psychiatry Global Open Science, Journal Year: 2025, Volume and Issue: unknown, P. 100483 - 100483

Published: March 1, 2025

Language: Английский

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Substance Use Disorders in Adolescents: A Qualitative Systematic Review

Journal of Advanced Nursing, Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

ABSTRACT Introduction It is important for the treatment and care of adolescents using substances to bring out their life experiences relating substance use. Aim To analyse synthesise qualitative evidence on use‐related with use disorder. Design A systematic review studies. Methods Systematic searches databases PubMed, Science Direct, Scopus, EBSCO CINAHL Complete Web were conducted between December 2023 February 2024 supplemented by manual search strategies. As a result search, 1271 articles accessed 11 included in study. In order assess quality, critical appraisal skills programme was used. Synthesis data performed thematic analysis method recommended Thomas Harden (2008). study reporting, preferred reporting items reviews meta‐analyses (PRISMA) 2020 checklist enhancing transparency synthesis research (ENTREQ) guidelines Results From publications, four main themes emerged: starting continuing use, duration dependence related factors, results process. Conclusions Substance disorder had serious negative effects themselves, families environments. line these experiences, made suggestions regarding Implications Profession and/or Patient Care Professionals working can plan interventions who substances. addition, governments take into account when structuring health policies. or Public Contribution No patient public contribution. Registration This meta‐synthesis registered PROSPERO (CRD42022298218).

Language: Английский

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