Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: 2(11), P. 944 - 959
Published: July 15, 2024
Language: Английский
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: Aug. 9, 2023
Natural Killer (NK) cells are a type of innate lymphoid that play crucial role in immunity by killing virally infected or tumor and secreting cytokines chemokines. NK cell-mediated immunotherapy has emerged as promising approach for cancer treatment due to its safety effectiveness. cell engagers (NKCEs), such BiKE (bispecific killer engager) TriKE (trispecific engager), novel class antibody-based therapeutics exhibit several advantages over other immunotherapies harnessing cells. By bridging cells, NKCEs activate lead lysis. A growing number currently undergoing development, with some already clinical trials. However, there is need more comprehensive studies determine how the molecular design affects their functionality manufacturability, which development off-the-shelf drugs treatment. In this review, we summarize current knowledge on NKCE discuss critical factors required production effective NKCEs.
Language: Английский
Citations
24
Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 261, P. 155489 - 155489
Published: July 27, 2024
Language: Английский
Citations
13
Experimental Hematology and Oncology, Journal Year: 2024, Volume and Issue: 13(1)
Published: Aug. 5, 2024
Abstract Chimeric antigen receptor macrophage (CAR-MΦ) represents a significant advancement in immunotherapy, especially for treating solid tumors where traditional CAR-T therapies face limitations. CAR-MΦ offers promising approach to target and eradicate tumor cells by utilizing macrophages’ phagocytic antigen-presenting abilities. However, challenges such as the complex microenvironment (TME), variability expression, immune suppression limit their efficacy. This review addresses these issues, exploring mechanisms of action, optimal construct designs, interactions within TME. It also delves into ex vivo manufacturing CAR-MΦ, discussing autologous allogeneic sources importance stringent quality control. The potential synergies integrating with existing cancer like checkpoint inhibitors conventional chemotherapeutics are examined highlight possible enhanced treatment outcomes. Furthermore, regulatory pathways scrutinized alongside established protocols cells, identifying unique considerations essential clinical trials market approval. Proposed safety monitoring frameworks aim manage adverse events, cytokine release syndrome, crucial patient safety. Consolidating current research insights, this seeks refine therapeutic applications, overcome barriers, suggest future directions transition from experimental platforms standard care options.
Language: Английский
Citations
12
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(20)
Published: April 23, 2024
Abstract Cancer immunotherapy recently transforms the traditional approaches against various cancer malignancies. Immunotherapy includes systemic and local treatments to enhance immune responses involves strategies such as checkpoints, vaccines, modulatory agents, mimetic antigen‐presenting cells, adoptive cell therapy. Despite promising results, these still suffer from several limitations including lack of precise delivery immune‐modulatory agents target cells off‐target toxicity, among others, that can be overcome using nanotechnology. Mesoporous silica nanoparticles (MSNs) are investigated improve aspects attributed advantageous structural features this nanomaterial. MSNs engineered alter their properties size, shape, porosity, surface functionality, adjuvanticity. This review explores immunological use vehicles for immune‐adjuvants, (APCs). The also details current remodel tumor microenvironment positively reciprocate toward anti‐tumor in combination with other therapies photodynamic/thermal therapeutic effect cancer. Last, present demands future scenarios discussed.
Language: Английский
Citations
11
Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: 2(11), P. 944 - 959
Published: July 15, 2024
Language: Английский
Citations
11