Recent advances on gene-related DNA methylation in cancer diagnosis, prognosis, and treatment: a clinical perspective DOI Creative Commons
Alessandro Lavoro,

Daria Ricci,

Giuseppe Gattuso

et al.

Clinical Epigenetics, Journal Year: 2025, Volume and Issue: 17(1)

Published: May 5, 2025

Abstract Recent advances in screening programs and the development of innovative therapeutic strategies have significantly improved clinical outcomes cancer patients. However, many patients still experience treatment failure, primarily due to inherent or acquired drug resistance mechanisms. This challenge underscores urgent need for novel targets effective malignancies, as well cancer-specific biomarkers enhance early diagnosis guide interventions. Epigenetic mechanisms, including DNA methylation, recently garnered growing interest key regulators gene expression under both physiological pathological conditions. Although epigenetic dysregulations are reliable tumor hallmarks, methylation is not routinely integrated into practice, highlighting further research translate preclinical findings from bench bedside. On these bases, present review aims illustrate state art regarding role cancer, describing technologies currently available profiling. Furthermore, latest evidence on application hotspots prognosis, impact epidrugs care, discussed provide a comprehensive overview potential relevance advancing personalized medicine.

Language: Английский

Recent advances on gene-related DNA methylation in cancer diagnosis, prognosis, and treatment: a clinical perspective DOI Creative Commons
Alessandro Lavoro,

Daria Ricci,

Giuseppe Gattuso

et al.

Clinical Epigenetics, Journal Year: 2025, Volume and Issue: 17(1)

Published: May 5, 2025

Abstract Recent advances in screening programs and the development of innovative therapeutic strategies have significantly improved clinical outcomes cancer patients. However, many patients still experience treatment failure, primarily due to inherent or acquired drug resistance mechanisms. This challenge underscores urgent need for novel targets effective malignancies, as well cancer-specific biomarkers enhance early diagnosis guide interventions. Epigenetic mechanisms, including DNA methylation, recently garnered growing interest key regulators gene expression under both physiological pathological conditions. Although epigenetic dysregulations are reliable tumor hallmarks, methylation is not routinely integrated into practice, highlighting further research translate preclinical findings from bench bedside. On these bases, present review aims illustrate state art regarding role cancer, describing technologies currently available profiling. Furthermore, latest evidence on application hotspots prognosis, impact epidrugs care, discussed provide a comprehensive overview potential relevance advancing personalized medicine.

Language: Английский

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