The Interplay of Stress, Inflammation, and Metabolic Factors in the Course of Parkinson’s Disease DOI Open Access

Tracey Shaul,

Dan Frenkel, Tanya Gurevich

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12409 - 12409

Published: Nov. 19, 2024

Parkinson's disease (PD) is a prevalent neurodegenerative condition for which there are symptomatic treatments but no disease-modifying therapies (DMTs). Extensive research over the years has highlighted need multi-target DMT approach in PD that recognizes various risk factors and their intricate interplay contributing to PD-related neurodegeneration. Widespread factors, such as emotional stress metabolic have increasingly become focal points of exploration. Our review aims summarize interactions between selected key players metabolism, insulin, potential mechanisms underlying neurodegeneration PD.

Language: Английский

Impaired unfolded protein response, BDNF and synuclein markers in postmortem dorsolateral prefrontal cortex and caudate nucleus of patients with depression and Parkinson's disease DOI Creative Commons
Unai Sarriés-Serrano, Lluís Miquel-Rio, Noemí Santana

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: 138, P. 111299 - 111299

Published: Feb. 25, 2025

Language: Английский

Citations

0
Multi-scale Neural Homeostasis Mechanisms: Insights into Neurodegenerative Diseases and Therapeutic Approaches, Including Exercise DOI Creative Commons
Ya Wang, Xuhui Chen, Cuntai Zhang

et al.

Advanced Exercise and Health Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
The Role of Microglia and Astrocytes in the Pathomechanism of Neuroinflammation in Parkinson’s Disease—Focus on Alpha-Synuclein DOI Creative Commons
Oliwia Harackiewicz, Beata Grembecka

Journal of Integrative Neuroscience, Journal Year: 2024, Volume and Issue: 23(11)

Published: Nov. 15, 2024

Glial cells, including astrocytes and microglia, are pivotal in maintaining central nervous system (CNS) homeostasis responding to pathological insults. This review elucidates the complex immunomodulatory functions of glial with a particular focus on their involvement inflammation cascades initiated by accumulation alpha-synuclein (α-syn), hallmark Parkinson’s disease (PD). Deriving insights from studies both sporadic familial forms PD, as well animal models we explore how cells contribute progression triggered α-syn aggregation. Additionally, analyze interplay between blood-brain barrier (BBB), highlighting role these BBB integrity permeability context PD pathology. Furthermore, delve into potential activation repair neuroprotective mechanisms mediated amidst α-syn-induced neuroinflammation. By integrating information dynamics, this aims deepen our understanding multifaceted interactions pathology, CNS inflammation, thereby offering valuable therapeutic strategies for related neurodegenerative disorders.

Language: Английский

Citations

2
The Interplay of Stress, Inflammation, and Metabolic Factors in the Course of Parkinson’s Disease DOI Open Access

Tracey Shaul,

Dan Frenkel, Tanya Gurevich

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12409 - 12409

Published: Nov. 19, 2024

Parkinson's disease (PD) is a prevalent neurodegenerative condition for which there are symptomatic treatments but no disease-modifying therapies (DMTs). Extensive research over the years has highlighted need multi-target DMT approach in PD that recognizes various risk factors and their intricate interplay contributing to PD-related neurodegeneration. Widespread factors, such as emotional stress metabolic have increasingly become focal points of exploration. Our review aims summarize interactions between selected key players metabolism, insulin, potential mechanisms underlying neurodegeneration PD.

Language: Английский

Citations

1