Emerging roles of microglia and neuroinflammation in Huntington's disease: From pathophysiology to clinical trials DOI Creative Commons

Muna Abedrabbo,

Pardis Kazemian,

Colúm Connolly

et al.

Journal of Huntington s Disease, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Microglia, the resident immune cells of central nervous system, play a pivotal role in response to Huntington's disease (HD) pathology. Through both cell-autonomous mechanisms and exposure external pathogenic stimuli, microglia transition from resting an activated state, producing pro-inflammatory cytokines chemokines that mediate inflammation. While this inflammatory attempts have neuroprotective compensatory effect, chronic microglial activation exacerbates neuroinflammation, neurodegeneration contributes progression. Evidence postmortem analyses neuroimaging studies indicates are present various stages HD, correlating with neuronal degeneration clinical symptoms. Enhanced has been identified as early predictor onset, particularly premanifest highlighting potential targeting pathways for therapeutic interventions. This review explores microglia's dual HD pathophysiology, exploring their contributions neuroinflammation neuroprotection. It also examines recent advances trials aimed at modulating activity, paving way novel strategies alter progression improve patient outcomes.

Language: Английский

snRNA-seq stratifies multiple sclerosis patients into distinct white matter glial responses DOI Creative Commons
Will Macnair,

Daniela Calini,

Eneritz Agirre

et al.

Neuron, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

4
Emerging roles of microglia and neuroinflammation in Huntington's disease: From pathophysiology to clinical trials DOI Creative Commons

Muna Abedrabbo,

Pardis Kazemian,

Colúm Connolly

et al.

Journal of Huntington s Disease, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Microglia, the resident immune cells of central nervous system, play a pivotal role in response to Huntington's disease (HD) pathology. Through both cell-autonomous mechanisms and exposure external pathogenic stimuli, microglia transition from resting an activated state, producing pro-inflammatory cytokines chemokines that mediate inflammation. While this inflammatory attempts have neuroprotective compensatory effect, chronic microglial activation exacerbates neuroinflammation, neurodegeneration contributes progression. Evidence postmortem analyses neuroimaging studies indicates are present various stages HD, correlating with neuronal degeneration clinical symptoms. Enhanced has been identified as early predictor onset, particularly premanifest highlighting potential targeting pathways for therapeutic interventions. This review explores microglia's dual HD pathophysiology, exploring their contributions neuroinflammation neuroprotection. It also examines recent advances trials aimed at modulating activity, paving way novel strategies alter progression improve patient outcomes.

Language: Английский

Citations

0