Large-scale genetic correlation studies explore the causal relationship and potential mechanism between gut microbiota and COVID-19-associated risks

BMC Microbiology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 5, 2024

Recent observational studies suggest that gut microorganisms are involved in the onset and development of coronavirus disease 2019 (COVID-19), but potential causal relationship behind them remains unclear. Exposure data were derived from MiBioGen consortium, encompassing 211 microbiota (n = 18,340). The outcome sourced COVID-19 host genetics initiative (round 7), including severity 1,086,211), hospitalization 2,095,324), susceptibility 2,597,856). First, a two-sample Mendelian randomization (TSMR) was performed to investigate effect between outcomes. Second, two-step MR used explore mediators underlying mechanisms. Third, several sensitivity analyses verify robustness results. Five microbes found have causality with severity, namely Betaproteobacteria (beta 0.096, p 0.034), Christensenellaceae -0.092, 0.023), Adlercreutzia 0.072, 0.048), Coprococcus 1 0.089, 0.032), Eisenbergiella 0.064, 0.024). Seven hospitalization, Victivallaceae 0.037, 0.028), Actinomyces 0.047, 0.046), 2 -0.061, 0.031), Dorea 0.067, 0.016), Peptococcus -0.035, 0.049), Rikenellaceae RC9 group 0.034, 0.018), Proteobacteria -0.069, 0.035). Two susceptibility, Holdemanella -0.024, 0.023) Lachnospiraceae FCS020 0.026, 0.027). Multi-omics mediation indicate numerous plasma proteins, metabolites, immune factors critical linking Sensitivity analysis suggested no significant heterogeneity or pleiotropy. These findings revealed correlation mechanism outcomes, which may improve our understanding gut-lung axis etiology pathology future.

Language: Английский

Inhibitory neuron links the causal relationship from air pollution to psychiatric disorders: a large multi-omics analysis

Journal Of Big Data, Journal Year: 2024, Volume and Issue: 11(1)

Published: Sept. 11, 2024

Language: Английский