Form Equals Function: Influence of Coacervate Architecture on Drug Delivery Applications DOI Creative Commons

Chae-Young Lim,

Whitney C. Blocher McTigue

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(11), P. 6766 - 6789

Published: Oct. 18, 2024

Complex coacervates, formed through electrostatic interactions between oppositely charged polymers, present a versatile platform for drug delivery, providing rapid assembly, selective encapsulation, and responsiveness to environmental stimuli. The architecture properties of coacervates can be tuned by controlling structural design factors, which significantly impact the stability delivery efficiency drugs. While factors such as salt, pH, temperature play crucial role in coacervate formation, polymer concentration, structure, mixing ratio, chain length serve core framework that shapes architecture. These elements modulate phase behavior material allowing highly tunable system. In this review, we primarily analyze how these contribute formation diverse architecture, ranging from bulk polyion complex micelles, vesicles, cross-linked gels, though are considered. We then examine effectiveness architectures enhancing efficacy drugs across various administration routes, noninvasive (e.g., oral transdermal) invasive delivery. This review aims provide foundational insights into advanced systems examining origin chemical structure polymers influence turn defines their properties. explore tailored optimize specific routes. approach leverages intrinsic derived enable targeted, controlled, efficient release, ultimately therapeutic outcomes precision medicine.

Language: Английский

Impact of nanoemulsion of Ajwain-cardamom essential oils on Mortadella sausage quality during chilling (4oC) storage DOI Creative Commons

Elmira Taherzadeh,

Akram Arianfar,

Elham Mahdian

et al.

Heliyon, Journal Year: 2025, Volume and Issue: 11(1), P. e41643 - e41643

Published: Jan. 1, 2025

Essential oils application as natural preservatives is challenging owning to low solubility and stability harsh conditions, while incorporation of essential into nanoemulsion systems can effectively improve these issues. Therefore, the ajwain (C. copticum) cardamom were fabricated through self-emulsification technique evaluated their size, ζ-potential, antioxidative antibacterial activities. The effect double nanomulsion on textural sensorial properties Mortadella sausage was also examined under chilling temperature (4 °C). Our goal storage by using preservative. By increasing oil in nanoemulsion, protein moisture increased, fat content decreased (17 %). Furthermore, showed particle size less than 100 nm PDI<0.5 revealing nanoemulsions. Moreover, nanoemulsions exhibited higher activity against S. aureus IC50 DPPH value (107 ppm). had a greater Mortadella, reduction hardness (∼5300 g), chewiness (∼2500 g mm). Ajwain/cardamom increased sensory properties, particularly taste acceptance Mortadella. Consequently, not only mortadella at due antioxidant antimicrobial but has positive red color created special herbal aroma, odor samples, which ultimately contributed customer-friendly product. appropriate dose develop meat products lowest amount nitrite formulations, although, further research should be conducted mechanism action AEO/CEO concerning appearance products.

Language: Английский

Citations

3
The application of the coacervation technique for microencapsulation bioactive ingredients: a critical review DOI Creative Commons

Narmin Nezamdoost-Sani,

Saber Amiri, Amin Mousavi Khaneghah

et al.

Journal of Agriculture and Food Research, Journal Year: 2024, Volume and Issue: unknown, P. 101431 - 101431

Published: Sept. 1, 2024

Language: Английский

Citations

13
Spray drying of saffron extract-loaded coacervates by carboxymethyl cellulose/maltodextrin/saffron petal anthocyanins DOI Creative Commons

Hamid Rajabi,

Samineh Sedaghati,

Hamidreza Farajnezhad

et al.

Carbohydrate Polymer Technologies and Applications, Journal Year: 2025, Volume and Issue: unknown, P. 100690 - 100690

Published: Jan. 1, 2025

Language: Английский

Citations

2
Microencapsulation of Acer truncatum seed oil using chickpea protein isolate–low/high-methoxy citrus pectin complex coacervates: Preparation, stability analysis, and application in milk DOI
Mo Chen, Bo Zhang, Min Wang

et al.

Food Hydrocolloids, Journal Year: 2025, Volume and Issue: unknown, P. 111368 - 111368

Published: March 1, 2025

Language: Английский

Citations

1
Effect of pH and protein to polysaccharide ratio on coacervation of sesame protein isolate-Tragacanth gum: Structure-rheology function DOI

Azade Ghorbani,

Ali Rafe, Mohammad Ali Hesarinejad

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143911 - 143911

Published: May 1, 2025

Language: Английский

Citations

0
Adsorption Kinetics and Interfacial Dilatational Rheology of Oil–Water Interfacial Films Loaded with Homogalacturonan and Rhamnogalacturonan-I DOI
Hui Niu,

Wenduo Wang,

Haiming Chen

et al.

ACS Food Science & Technology, Journal Year: 2024, Volume and Issue: 4(8), P. 1967 - 1977

Published: July 26, 2024

Our recent study on the isolation of rhamnogalacturonan-I (RG-I) pectin enriched with acetyl groups, ferulic acid, neutral sugar side chains, and proteins through enzymatic hydrolysis homogalacturonan (HG) region beet showed that RG-I molecules can form more stable emulsions than HG molecules. In this experiment, interfacial adsorption kinetics at oil–water interface resistance effects these films extrinsic perturbations were further investigated. All experimental results indicated RG-I-stabilized film presented better elasticity (43.36 mN/m) stronger to (12.41 mN/m). addition, both HG- RG-I-loaded exhibited linear viscoelastic responses when a small deformation low-frequency perturbation applied. When increased further, RG-loaded underwent strain softening during extension stage. However, in compression stage, HG-loaded hardening, whereas softening.

Language: Английский

Citations

2
Polysaccharide-potato protein coacervates for enhanced anthocyanin bioavailability and stability DOI
Havva Aktaş, Jorge A. Custodio‐Mendoza, Arkadiusz Szpicer

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 136829 - 136829

Published: Oct. 28, 2024

Language: Английский

Citations

2
Form Equals Function: Influence of Coacervate Architecture on Drug Delivery Applications DOI Creative Commons

Chae-Young Lim,

Whitney C. Blocher McTigue

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(11), P. 6766 - 6789

Published: Oct. 18, 2024

Complex coacervates, formed through electrostatic interactions between oppositely charged polymers, present a versatile platform for drug delivery, providing rapid assembly, selective encapsulation, and responsiveness to environmental stimuli. The architecture properties of coacervates can be tuned by controlling structural design factors, which significantly impact the stability delivery efficiency drugs. While factors such as salt, pH, temperature play crucial role in coacervate formation, polymer concentration, structure, mixing ratio, chain length serve core framework that shapes architecture. These elements modulate phase behavior material allowing highly tunable system. In this review, we primarily analyze how these contribute formation diverse architecture, ranging from bulk polyion complex micelles, vesicles, cross-linked gels, though are considered. We then examine effectiveness architectures enhancing efficacy drugs across various administration routes, noninvasive (e.g., oral transdermal) invasive delivery. This review aims provide foundational insights into advanced systems examining origin chemical structure polymers influence turn defines their properties. explore tailored optimize specific routes. approach leverages intrinsic derived enable targeted, controlled, efficient release, ultimately therapeutic outcomes precision medicine.

Language: Английский

Citations

0