Stem Cell-Laden Engineered Patch: Advances and Applications in Tissue Regeneration DOI

Su-Jin Heo,

Moon Jong Noh,

Y.S. Kim

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

Stem cell-based therapies are emerging as significant approaches in tissue engineering and regenerative medicine, applicable to both fundamental scientific research clinical practice. Despite remarkable results studies, challenges such poor standardization of graft tissues, limited sources, reduced functionality have hindered the effectiveness these therapies. In this review, we summarize involved fabricating stem cell assisted patches substantial strategies for designing cell-laden engineered (SCP) complement existing We then outline potential applications SCP advancing regeneration medicine. By combining living cells with patches, can enhance functions components, particularly applications. Finally, addressed current challenges, ethical considerations, high costs, regulatory hurdles proposed future directions overcome barriers.

Language: Английский

Silk fibroin microneedles loaded with melatonin for circadian rhythm regulation DOI
Xiaoyue Li,

Yanai Chen,

Huiyan Shao

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 301, P. 140500 - 140500

Published: Jan. 30, 2025

Language: Английский

Citations

2
Microneedle-based nanodrugs for tumor immunotherapy DOI

Tianye Wang,

Hongyu Liu, Meng Li

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 539 - 562

Published: Feb. 13, 2025

Language: Английский

Citations

1
Nanomaterial-Enhanced Microneedles: Emerging Therapies for Diabetes and Obesity DOI Creative Commons
Mehrnaz Abbasi,

Divine Afunu Boka,

Hannah DeLoit

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(10), P. 1344 - 1344

Published: Oct. 21, 2024

Drug delivery systems (DDS) have improved therapeutic agent administration by enhancing efficacy and patient compliance while minimizing side effects. They enable targeted delivery, controlled release, bioavailability. Transdermal drug (TDDS) offer non-invasive medication evolved to include methods such as chemical enhancers, iontophoresis, microneedles (MN), nanocarriers. MN technology provides innovative solutions for chronic metabolic diseases like diabetes obesity using various types. For management, MNs continuous glucose monitoring, diabetic wound healing, painless insulin delivery. treatment, provide sustained transdermal of anti-obesity drugs or nanoparticles (NPs). Hybrid integrating wearable sensors smart materials enhance treatment effectiveness management. Nanotechnology has advanced nano-scaled liposomes polymeric NPs with MNs. In glucose-responsive facilitate At the same time, lipid nanocarriers in dissolving extended release stability absorption disorder therapies. DDS are advancing toward personalized treatments enhanced nanomaterials. These approaches can outcomes through precise real-time monitoring. However, widespread implementation faces challenges ensuring biocompatibility, improving technologies, scaling production, obtaining regulatory approval. This review will present recent advances developing applying nanomaterial-enhanced management also discussing challenges, limitations, future perspectives these DDS.

Language: Английский

Citations

5
Application and Development of Nanotechnology in Traditional Chinese Acupuncture in Recent 20 Years: A Comprehensive Review DOI
Lisha Liu, Xinzi Hu,

Yilin Su

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Acupuncture, rooted in Traditional Chinese Medicine (TCM), serves as a complementary and alternative therapeutic modality that involves the insertion of needles into specific body points to stimulate treat variety conditions. Over time, acupuncture has garnered global acceptance, progressively addressing an increasing spectrum medical disorders. The integration nanotechnology holds considerable potential improve drug delivery efficacy broaden scope acupuncture's applications, providing novel opportunities for investigating underlying principles meridians acupoints. A bibliometric analysis application over past two decades (2004-2024) highlights emerging research trends focal field. This article provides overview history, biological mechanisms, preparation methods, clinical status nanoacupuncture, with focus on analyzing applications nanoacupuncture technology. Nanotechnology enables visualization imaging acupoints, facilitating deeper understanding physiological mechanisms behind effects. Modified incorporating can serve dual purposes: functioning sensors real-time monitoring various parameters, thereby supporting disease diagnosis enhancing through specialized interventions. Furthermore, nanotechnology-enhanced act platforms targeted working tandem responsive nanoparticles treatment. Despite its promising applicability, faces inherent limitations challenges must be addressed.

Language: Английский

Citations

0
Applications of Matrix Metalloproteinase-9-Related Nanomedicines in Tumors and Vascular Diseases DOI Creative Commons
Xuying Li, Zhuping Xu

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 479 - 479

Published: April 7, 2025

Matrix metalloproteinase-9 (MMP-9) is implicated in tumor progression and vascular diseases, contributing to angiogenesis, metastasis, extracellular matrix degradation. This review comprehensively examines the relationship between MMP-9 these pathologies, exploring underlying molecular mechanisms signaling pathways involved. Specifically, we discuss contribution of epithelial–mesenchymal transition, as well its involvement a spectrum including macrovascular, cerebrovascular, ocular diseases. focuses on recent advances MMP-9-targeted nanomedicine strategies, highlighting design application responsive nanoparticles for enhanced drug delivery. These nanotherapeutic strategies leverage overexpression achieve targeted release, improved penetration, reduced systemic toxicity. We explore various nanoparticle platforms, such liposomes polymer nanoparticles, their action, degradation, targeting specificity. Finally, address challenges posed by heterogeneity expression implications personalized therapies. Ultimately, this underscores diagnostic therapeutic potential nanomedicines against tumors

Language: Английский

Citations

0
Transdermal Delivery of Timolol Maleate Using Hydrogel Microneedles for the Treatment of Infantile Haemangiomas DOI Creative Commons
Xiaokun Lin, Tongshuai Kuang, Lei Wang

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101752 - 101752

Published: April 12, 2025

Infantile haemangioma (IH), the most prevalent vascular tumour in infants, requires early intervention because of potential complications critical areas such as head and face. Current treatments, including topical timolol maleate (TIM), face challenges poor compliance, low drug utilisation, lengthy treatment durations. In this study, we developed a hydrogel microneedle (MN) using photocurable bovine serum albumin methacryloyl (BSAMA) carrier for TIM. Our results showed controlled release TIM from BSAMA-TIM MNs, with approximately 69 % ratio within 72 h. In-vivo studies on nude mice demonstrated that BSAMA-TIM-MNs inhibited growth xenografts. TIM-delivering MNs exhibited high therapeutic efficacy, minimal cytotoxicity, reduced dosing frequency. conclusion, provide promising strategy treating IH.

Language: Английский

Citations

0
Progress of microneedle targeted modulation technology in the reconstruction of immune microenvironment in diabetic wounds DOI Creative Commons

Shunsheng Wang,

Wei Cheng,

Xue Wang

et al.

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: May 20, 2025

Wound healing in diabetic patients is mainly hindered by a combination of long-term glycosylation, persistent inflammatory response, and immunosuppressive state. The interaction these factors not only results considerable prolongation the wound process but also elevates likelihood recurrent ulcer development, profoundly affecting patients' quality life. Traditional treatments, including surgical debridement, anti-infection, dressing application, vascular intervention, glycaemic control, can relieve some symptoms. However, they are often ineffective addressing underlying cause impaired healing. It concern that importance immune microenvironment has yet been fully appreciated investigated, homeostasis crucial for promoting cell proliferation, angiogenesis, tissue repair. this dysregulated This paper reviews key leading to dysregulation microenvironment, dysfunction, abnormal cytokine expression, disruption signalling pathways, introduces an innovative silicone-based microneedle drug delivery method, which takes advantage microneedle's precise targeting highly efficient loading capacity deliver drugs with immunomodulatory functions directly sustained manner, activate corresponding promote polarization M1 macrophages into M2 phenotype, stimulate neovascularization, providing low pro-angiogenic healing, provides new therapeutic idea means

Language: Английский

Citations

0
Nano-fluorescence imaging: advancing lymphatic disease diagnosis and monitoring DOI Creative Commons
Catherine Y. Han,

Sang‐Hun Choi,

Soo‐Hyang Chi

et al.

Nano Convergence, Journal Year: 2024, Volume and Issue: 11(1)

Published: Dec. 11, 2024

The lymphatic system plays a crucial role in maintaining physiological homeostasis and regulating immune responses. Traditional imaging modalities such as magnetic resonance imaging, computerized tomography, positron emission tomography have been widely used to diagnose disorders the system, including lymphedema, lymphangioma, metastasis, Castleman disease. Nano-fluorescence technology has distinct advantages-including naked-eye visibility, operational simplicity, portability of laser, real-time visibility-and serves an innovative alternative traditional techniques. This review explores recent advancements nano-fluorescence aimed at enhancing resolution structure, function, immunity. After delineating fundamental characteristics systems, it elaborates on development various systems (including nanoparticles incorporating fluorescent dyes those with intrinsic fluorescence) while addressing key challenges photobleaching, limited tissue penetration, biocompatibility, signal interference from biomolecules. Furthermore, this highlights clinical applications its potential integration into standard diagnostic protocols. Ongoing nanoparticle underscore revolutionize diagnosis treatment

Language: Английский

Citations

1
Exploring lecithin’s structural diversity to control core crystallinity in poly(ethylene oxide)-b-poly(ɛ-caprolactone) nanocarriers DOI

Uyen Thi,

Minji Song,

Jiwon Kim

et al.

European Polymer Journal, Journal Year: 2024, Volume and Issue: unknown, P. 113652 - 113652

Published: Dec. 1, 2024

Language: Английский

Citations

0
Stem Cell-Laden Engineered Patch: Advances and Applications in Tissue Regeneration DOI

Su-Jin Heo,

Moon Jong Noh,

Y.S. Kim

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

Stem cell-based therapies are emerging as significant approaches in tissue engineering and regenerative medicine, applicable to both fundamental scientific research clinical practice. Despite remarkable results studies, challenges such poor standardization of graft tissues, limited sources, reduced functionality have hindered the effectiveness these therapies. In this review, we summarize involved fabricating stem cell assisted patches substantial strategies for designing cell-laden engineered (SCP) complement existing We then outline potential applications SCP advancing regeneration medicine. By combining living cells with patches, can enhance functions components, particularly applications. Finally, addressed current challenges, ethical considerations, high costs, regulatory hurdles proposed future directions overcome barriers.

Language: Английский

Citations

0