Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 28, 2024
Abstract
Surface‐enhanced
Raman
spectroscopy
(SERS)
has
become
a
revolutionary
technique
in
the
biomedical
field,
providing
unparalleled
sensitivity
for
detection
and
characterization
of
biological
samples.
In
this
review,
recent
SERS
innovations
are
comprehensively
discussed,
including
advanced
substrate
materials,
different
strategies,
multimodal
approaches
that
combine
with
other
biotechnologies.
Among
them,
role
accurate
diagnosis
tumors
is
highlighted,
which
promoted
molecular
analysis
real‐time
monitoring
treatment
effects.
addition,
growing
potential
chronic
diseases
such
as
cardiovascular
disease,
diabetes,
neurodegenerative
discussed.
Moreover,
integration
microfluidic
chip
systems
precise
single‐cell
presented.
To
give
forward‐looking
view,
key
challenges
faced
by
technology
also
proposed,
possible
solutions
to
overcome
these
obstacles
provided.
Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 15, 2024
Metal-organic
frameworks
(MOFs)
are
composed
of
metal
nodes
and
organic
linkers
that
can
self-assemble
into
an
infinite
network.
The
high
porosity
large
surface
area
MOFs
facilitate
the
effective
enrichment
mass
transfer
analytes,
which
enhance
signal
response
improve
sensitivity
electrochemical
sensors.
Additionally,
their
derivatives
possess
properties
unsaturated
sites
tunable
structures,
collectively
demonstrating
potential
for
sensing.
This
paper
summarizes
preparation
methods,
structural
properties,
applications
in
sensing,
emphasizing
sensors'
selectivity
from
perspectives
direct
indirect
detection.
it
also
explores
future
directions
prospects
with
aim
overcoming
current
limitations
through
innovative
approaches.
Lab on a Chip,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
The
synergy
between
nanoplasmonic
and
microfluidics
opens
a
wealth
of
possibilities
that
span
through
several
research
fields
areas
applications,
ranging
from
analytical
chemistry
to
modern
optofluidic
devices.
ACS Sensors,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 30, 2025
Bacterial
infections,
such
as
sepsis,
require
prompt
and
precise
identification
of
the
causative
bacteria
for
appropriate
antibiotics
treatment.
Traditional
methods
culturing
take
2-5
days,
while
newer
techniques
reverse
transcription-polymerase
chain
reaction
mass
spectrometry
are
hindered
by
blood
impurities.
Consequently,
this
study
developed
a
surface-enhanced
Raman
scattering
(SERS)-based
acoustofluidic
technique
rapid
bacterial
detection
without
or
lysing.
Target
first
tagged
with
SERS
nanotags
in
microtube.
The
solution
unbound
is
passed
through
silicon
microfluidic
channel.
A
piezoelectric
transducer
generates
acoustic
waves
within
channel,
concentrating
larger
center
pushing
smaller
toward
channel
walls.
laser
beam
focused
at
signals
passing
focal
volume
measured
quantitative
analysis.
As
proof
concept,
detected
various
concentrations
Escherichia
coli
limit
1.75
×
105
CFU/mL
1
h.
This
method
offers
significant
clinical
potential,
enabling
accurate
genetic
material
extraction,
cultivation,
lysis.
Frontiers in Nanotechnology,
Journal Year:
2025,
Volume and Issue:
6
Published: Jan. 15, 2025
Hospitals
and
other
healthcare
facilities
harbor
a
complex
interplay
of
microbial
pathogens.
The
correct
understanding
pathogens
distribution
evolution
is
therefore
crucial
for
infections
control
the
design
effective
prevention
strategies.
In
parallel,
integration
cutting-edge
nanotechnologies
early
detection
monitoring
these
specific
target
considered
most
approach
to
face
nosocomial
infections.
this
context,
point-of-care
(POC)
testing,
also
known
as
near-patient
becoming
increasingly
important.
review
we
provide
systematic
insight
into
recent
scientific
technological
advances
in
pathogen
that
explore
advanced
realize
devices
nanobiosensors,
with
improved
selectivity
sensitivity.
particular,
report
on
diffused
affordable
developed
still
developing
POC
aim
increase
sensitivity,
speed
accuracy
different
environments,
from
intensive
care
units
outside
laboratory
hospital
settings.
text
sub-divided
several
sections,
each
one
focused
type
nanomaterials
techniques
actually
employed.
This
paper
reviews
the
latest
research
progress
of
surface-enhanced
Raman
spectroscopy
(SERS)
microfluidic
chips
in
field
biosensing.
Due
to
its
single-molecule
sensitivity,
selectivity,
minimal
or
no
preprocessing,
and
immediacy,
SERS
is
considered
a
promising
biosensing
technology.
However,
nondirectional
interactions
between
biological
samples
substrate,
as
well
fluctuations
sample
environment
temperature
during
signal
acquisition,
can
affect
stability
reproducibility
signals.
Integrating
with
not
only
leverages
continuous
flow,
high
reaction
efficiency,
throughput,
multifunctionality
address
challenges
applications
but
also
expands
scope
technology
by
providing
novel
on-chip
optical
detection
method.
The
combination
enables
complementary
advantages
both
technologies
offers
highly
"combined
technology"
for
starts
introducing
enhancement
mechanisms
presents
labeled
label-free
strategies.
Based
on
differences
substrate
properties,
we
broadly
categorize
into
colloidal
nanoparticle-based
fixed
substrate-based
chips.
Finally,
review
targets
such
nucleic
acids,
proteins,
small
biomolecules,
live
cells.
In
conclusion
outlook
section,
summarize
faced
propose
feasible
solutions.
To
better
leverage
role
biosensing,
present
an
future
development
this
combined
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 4, 2025
Surface-enhanced
Raman
scattering
(SERS)
has
emerged
as
a
potent
spectroscopic
technique
for
the
detection
of
single
cells.
However,
it
is
difficult
to
achieve
label-free
at
single-cell
level
in
dynamic
liquids
because
nanoprobe
aggregation
biological
fluids
and
low
combination
nanoprobes
cells
reduce
sensitivity
SERS
detection.
Herein,
liquid
integrated
(DLISC-SERS)
platform
developed
cancer
DLISC-SERS
consists
three
components,
including
twisted
mixing
microfluidic
chip
an
efficient
cells,
commercial
coaxial
needle
accomplish
3D
focusing
by
annular
sheath
flow,
quartz
capillary
offer
area
with
noise.
The
intensity
almost
3.67-fold
higher
than
that
straight
mixing.
multifunctionally
modified
nanoprobe,
Ag
NSs@PEG@3COOH,
can
be
stably
dispersed
least
30
min.
segment
weighting
similarity-based
KNN
model
classify
spectra
sensitivity,
specificity,
accuracy
up
100,
99.4,
99.5%,
respectively.
three-way
classification
95.2%.
powerful
tool
detecting
level.
