Multi-organ comparison and quantification parameters of [18F]THK-5317 uptake in preclinical mouse models of tau pathology DOI Creative Commons
Thomas Wanek, Severin Mairinger,

Thomas Filip

et al.

Frontiers in Physics, Journal Year: 2023, Volume and Issue: 11

Published: Dec. 15, 2023

Introduction: Current small-animal PET instrumentation provides sufficient resolution, sensitivity, and quantitative accurate information on the radiotracer distribution within whole body. However, most preclinical imaging studies focus disease-related organ of interest do not use total body provided by PET. In this study, we investigated [ 18 F]THK-5317 (also referred to as ( S )-[ F]THK-5117), a initially developed visualize tau deposits in brain, two transgenic mouse models overexpression littermate controls at different ages both sexes. We compared multiple parameters uptake organs mice investigate sex, age, or strain-related differences. Methods: After intravenous administration, 60-min dynamic scans were acquired, followed venous blood sampling, harvesting, metabolite analysis radio-thin-layer chromatography. Results: Blood pharmacokinetics metabolism significantly differed between males females across all strains. Sex-related differences V T s identified from two-way ANOVA analysis. Organ-to-blood concentration ratios correlated well with organs. Conclusion: Following our workflow, straightforward multiple-organ was easily achievable. From derived parameters, organ-to-blood values correlate best calculated s. Given active incorporation 3R principles into imaging, propose that workflow might be suitable select novel candidates before more complex kinetic models, comprising invasive methods such full arterial for quantification are applied.

Language: Английский

Rare-Earth Doped Bi4Ge3O12 Crystals: Advances in Growth Techniques and Luminescence Properties for Laser Applications DOI
Jie Xu, Y. Guyot, Jian Liu

et al.

Optics Communications, Journal Year: 2025, Volume and Issue: unknown, P. 131730 - 131730

Published: March 1, 2025

Language: Английский

Citations

0
A Monte Carlo Simulation study on the design and optimization of collimators for non-collinear cascade gamma-ray correlation emissions in medical imaging DOI Creative Commons

Leonid Leopold Nkuba,

Innocent J. Lugendo

Brazilian Journal of Radiation Sciences, Journal Year: 2025, Volume and Issue: 13(1), P. e2573 - e2573

Published: March 21, 2025

This study focused on designing and optimizing collimators for cascade gamma-ray imaging through Monte Carlo simulations. The trapezoidal-shaped collimator blocks, designed in the Geant4 application emission tomography (GATE) environment, were attached to a simulated small animal GATE - PET model. optimized by simulating septa thicknesses from 0.2 mm 1.2 mm, increments. A 1.0 MBq 111In source having radius of 0.25 was used as emitter. Sixteen trapezoidal tungsten blocks designed, each with 16.31 × 37.5 surface facing detector crystals, 12.33 scanned object. Each block featured 105 parallel rectangular holes arranged 7 15 array, length 10.0 resulting ring-like 41.0 outer radius. collimator, intended imaging, prioritizes resolution. Hence, hole sizes 1.5 0.7 offering spatial resolutions 7.6 4.1 axial transaxial directions, respectively, chosen. demonstrated energy resolution approximately 8.96% 10.10% at 171.3 keV 245.4 keV, within 10% threshold set during Besides, reconstructed positions ranged 81.1% 100% true field view. design presents viable solution animals’ internal organs, exceeding mm.

Language: Английский

Citations

0
A new design to improve time resolution in a time of flight brain PET using dual layer offset scintillator crystals DOI Creative Commons

Amir Beheshti,

Alireza Karimian,

Hossein Arabi

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 5, 2025

Language: Английский

Citations

0
The detection instrumentation and geometric design of clinical PET scanner: towards better performance and broader clinical applications DOI
Abdallah El Ouaridi, Z. Ait Elcadi,

M. Mkimel

et al.

Biomedical Physics & Engineering Express, Journal Year: 2024, Volume and Issue: 10(3), P. 032002 - 032002

Published: Feb. 27, 2024

Positron emission tomography (PET) is a powerful medical imaging modality used in nuclear medicine to diagnose and monitor various clinical diseases patients. It more sensitive produces highly quantitative mapping of the three-dimensional biodistribution positron-emitting radiotracers inside human body. The underlying technology constantly evolving, recent advances detection instrumentation PET scanner design have significantly improved diagnosis capabilities this modality, making it efficient opening way broader, innovative, promising applications. Some significant achievements related include introducing new scintillators photodetectors as well developing innovative detector designs coupling configurations. Other moving towards cylindrical geometry, 3D acquisition mode, trend wider axial field view shorter diameter. Further research on camera will be required advance by improving its performance extending applications while optimising radiation dose, image time, manufacturing cost. This article comprehensively reviews parameters system design. Firstly, an overview historical innovation has been presented, focusing instrumental technology. Secondly, we characterised main current detailed innovations trends that affect these performances practice. Finally, prospects for are presented discussed. system's enables us draw solid conclusions achieving best possible different needs

Language: Английский

Citations

2
A cost-effective field-programmable-gate-array-based pulse processor for biomedical imaging applications DOI Creative Commons
A. Refaey, Felipe Godinez, Ramsey D. Badawi

et al.

Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment, Journal Year: 2024, Volume and Issue: 1069, P. 169820 - 169820

Published: Aug. 29, 2024

This paper presents the design and evaluation of a cost-effective, high-spatial resolution, multichannel, field-programmable gate array (FPGA)-based readout system for Positron Emission Tomography (PET) detectors suitable clinical pre-clinical work in cancer other diseases. A key challenge PET imaging is precise measurement time arrival energy gamma photons originating from positron annihilation, along with position interaction within detector. These parameters enhance image quality by improving coincidence detection, excluding Compton-scattered photons, spatial resolution. We developed 16-channel using single silicon photomultiplier (SiPM) element efficient energy, time, measurements. Each channel incorporates an FPGA-based sigma-delta analog-to-digital converter (ΣΔ-ADC) tapped delay line (TDL) based time-to-digital (TDC) timing estimation. Performance characterization was performed through simulation, electronically generated waveform, actual detector signals three different scintillation crystals face dimensions 3 × mm2 depths 5 20 mm coupled to SiPM. also constructed tested modular 10x10 1.2x1.2x14 mm³ LSO 4x4 SiPM elements. Best resolution 9.3% at 511 KeV photopeak best (CTR) 210 ± 3.5 ps. Our balances cost-effectiveness performance contributes developments signal acquisition technology.

Language: Английский

Citations

2
Evaluation of monolithic crystal detector with dual-ended readout utilizing multiplexing method DOI Creative Commons

Xiangtao Zeng,

Zhiming Zhang, Daowu Li

et al.

Physics in Medicine and Biology, Journal Year: 2024, Volume and Issue: 69(8), P. 085003 - 085003

Published: March 14, 2024

Monolithic crystal detectors are increasingly being applied in positron emission tomography (PET) devices owing to their excellent depth-of-interaction (DOI) resolution capabilities and high detection efficiency. In this study, we constructed evaluated a dual-ended readout monolithic detector based on multiplexing method.

Language: Английский

Citations

1
Design and implementation of continuous bed motion (CBM) in Xtrim preclinical PET scanner for whole-body Imaging: MC simulation and experimental measurements DOI
Bahador Bahadorzadeh, Reza Faghihi,

Sedigheh Sina

et al.

Physica Medica, Journal Year: 2024, Volume and Issue: 123, P. 103395 - 103395

Published: June 5, 2024

Language: Английский

Citations

1
Prototype of a digitizer module based on multicycle-encoding FPGA ADC for a small animal PET DOI
Kejian Chen, Jiajun Qin, Lei Zhao

et al.

Journal of Instrumentation, Journal Year: 2023, Volume and Issue: 18(07), P. P07033 - P07033

Published: July 1, 2023

Abstract Current research in small animal positron emission tomography (PET) scanners focus on obtaining better spatial resolution and higher sensitivity. These enhancements of scanner performance result a corresponding increase the complexity electronics, which usually manifests through an number electronics channels. Analog-to-digital converters (ADCs) implemented field programmable gate arrays (FPGAs) are effective way to simplify complexity. In this paper, resource-saving multicycle-encoding structure FPGA-based ADC with automated calibration is proposed, achieves sampling rate 250 Msps. A digitizer module prototype containing 64 charge measurement channels based FPGA designed using Kintex-7 FPGA. The bits (ENOB) achieved 4.26 under 10.0555 MHz sine wave input. each channel than 5‰ full width half maximum 0.8 V signal input 3% inputs range 0.1 1.2 V. integral nonlinearity within ± 1%.

Language: Английский

Citations

1
LabPET II scanner performances improvement: Thermal stability control based on FPGA DOI Creative Commons
Aziz Oukaira, Dhaou Said, Jamal Zbitou

et al.

e-Prime - Advances in Electrical Engineering Electronics and Energy, Journal Year: 2023, Volume and Issue: 6, P. 100360 - 100360

Published: Nov. 24, 2023

The LabPET II detection module serves as the fundamental component within Positron Emission Tomography (PET) scanners designed for achieving ultra-high-resolution imaging of small to medium-sized animals well human brain. To ensure peak performance, it is imperative that this operates consistently at a stable temperature. In paper, we present an automatic and real-time method improve thermal control scanner by evacuating heat reduce overall temperature maintain stability system. Based on Thermo-Electric Cooler (TEC) process, our applies two numerical techniques, Computational Fluid Dynamics (CFD) Heat Transfer Analysis (HTA). Dirichlet Boundary Conditions (DBC) applied Application-Specific Integrated Circuit (ASIC) 25∘ C. real measurements confirm validate simulation results with Finite Element Method (FEM) based software COMSOL Multiphysics™. Field-Programmable Gate Array (FPGA) implementation Development Education (DE1) board performed comparative study. proposed both simple practical, ensures 35∘C duration operation scanner, which has complex structure.

Language: Английский

Citations

1
Performance Comparison of DOI-Encoding PET Detectors Based on 1.1-mm Pitch BGO Arrays With Different Reflectors DOI
Junwei Du, Shixian Du

IEEE Transactions on Radiation and Plasma Medical Sciences, Journal Year: 2024, Volume and Issue: 8(3), P. 257 - 262

Published: Feb. 5, 2024

Bismuth germanate (BGO)-based positron emission tomography (PET) detectors are potential candidates for low-dose imaging PET scanners, owing to the high stopping power and low background radiation of BGO. In this paper, we compared performance two dual-ended readout based on 15 × BGO arrays. Both arrays had same 1.1 mm pitch but utilized different reflectors - barium sulfate (BaSO

Language: Английский

Citations

0