Functions of Differentially Regulated miRNAs in Breast Cancer Progression: Potential Markers for Early Detection and Candidates for Therapy DOI Creative Commons

Kumar Subramanian,

Raghu Sinha

Biomedicines, Journal Year: 2024, Volume and Issue: 12(3), P. 691 - 691

Published: March 20, 2024

Breast cancer remains a major global health concern, emphasizing the need for reliable biomarkers to enhance early detection and therapeutic interventions. MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNA (~22 nt in length) molecules, which aberrantly expressed seem influence tumor behavior progression. Specific miRNA dysregulation has been associated with breast initiation, proliferation, invasion, metastasis. Understanding functional roles of these miRNAs provides valuable insights into intricate molecular mechanisms underlying The diagnostic potential as non-invasive is burgeoning area research. This review aims elucidate functions differentially regulated progression assess their markers detection, stage-specific biomarkers, targets. Furthermore, ability specific serve prognostic indicators predictors treatment response highlights clinical utility guiding personalized

Language: Английский

A Review on miRNAs in Enteric Bacteria‐mediated Host Pathophysiology: Mechanisms and Implications DOI Open Access
Ahmed S. Doghish, Ola Elazazy, Hend H. Mohamed

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(2)

Published: Feb. 1, 2025

ABSTRACT Recently, many studies focused on the billions of native bacteria found inside and all over human body, commonly known as microbiota, its interactions with eukaryotic host. One niches for such microbiota is gastrointestinal tract (GIT), which harbors hundreds to thousands bacterial species enteric bacteria. Changes in populations were linked various pathologies irritable bowel syndrome obesity. The gut microbiome could affect health status individuals. MicroRNAs (miRNAs) are one extensively studied small‐sized noncoding RNAs (ncRNAs) past decade explore their multiple roles disease. It was proven that miRNAs circulate almost body fluids tissues, showing signature patterns dysregulation associated pathologies. Both cellular circulating participate posttranscriptional regulation genes considered potential key regulators communication. This manuscript explores unique interplay between tract, emphasizing dual role shaping host‐microbiota dynamics. delves into molecular mechanisms by influence colonization host immune responses, linking these findings gut‐related diseases. review highlights innovative therapeutic diagnostic opportunities, offering insights targeted treatments dysbiosis‐associated

Language: Английский

Citations

0
Exosomal miR‐107 Derived From Cigarette Smoking‐Exposed Bronchial Epithelial Cells Aggravates Acute Lung Injury by Polarizing Macrophage to Proinflammatory Phenotype DOI
Xin Ni, Yufeng Lv, Lei Han

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(2)

Published: Feb. 1, 2025

ABSTRACT Exosomes are critical mediators of intercellular crosstalk and play significant roles in the progression various diseases including acute lung injury (ALI). However, specific role exosomes ALI remains largely unexplored. In investigation, we demonstrated that released from cigarette smoke extract (CSE)‐exposed bronchial epithelial cells (BEAS‐2B) facilitated M1 macrophage polarization. Notably, CSE exposure enhanced production miR‐107 within these exosomes. Inhibition markedly reversed polarization inflammatory responses vitro ameliorated vivo. Furthermore, exosomal was found to downregulate KLF4, thereby promoting inflammation macrophages. Collectively, findings demonstrate CSE‐exposed BEAS‐2B could induce via transmitting miR‐107, eventually ultimately contributing ALI, indicating a potential therapeutic strategy for ALI.

Language: Английский

Citations

0
Epigenetic insights of microRNAs: Pioneering cancer detection via advanced biosensors DOI

Parveen Usman,

Durairaj Sekar

International review of cell and molecular biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
MicroRNAs in Preeclampsia: Bridging Diagnosis and Treatment DOI Open Access
Angeliki Gerede, Sofoklis Stavros,

Maria Danavasi

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(6), P. 2003 - 2003

Published: March 15, 2025

Preeclampsia (PE) is a multifactorial hypertensive disorder that typically manifests after the twentieth week of pregnancy, significantly impacting perinatal mortality and neonatal morbidity. Its development influenced by immunological components, systemic inflammation, genetic factors, with placental malfunction playing crucial role. While many aspects its pathophysiology have been elucidated, key mechanisms remain incompletely understood. MicroRNAs (miRNAs), small noncoding RNA molecules regulate gene expression, emerged as promising biomarkers therapeutic targets in PE. Dysregulated miRNAs identified pregnant PE patients, highlighting their role disease onset. Placenta-specific miRNAs, such miR-210 miR-155, influence endothelial function, hypoxia responses, which are closely associated development. These play regulating trophoblast invasion, angiogenesis, immune modulation, further linking dysregulation to This review aims provide comprehensive overview PE, focusing on potential diagnostic targets. By integrating recent advancements molecular research, we explore implications clinical practice, particularly risk assessment, early detection, novel treatment strategies.

Language: Английский

Citations

0
Circulating MicroRNAs: functional biomarkers for melanoma prognosis and treatment DOI Creative Commons
Su Yin Lim,

Suzanah C. Boyd,

Russell J. Diefenbach

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 28, 2025

MicroRNAs (miRNAs) hold significant promise as circulating cancer biomarkers and unlike many other molecular markers, they can provide valuable insights that extend beyond tumour biology. The expression of miRNAs may parallel the cellular composition dynamic activity within microenvironment reveal systemic immune responses. functional complexity miRNAs-where a single miRNA regulate multiple messenger RNAs (mRNAs) to fine tune fundamental processes, mRNA be targeted by miRNAs-underscores their broad significance impact. However, this poses challenges for translating research into clinical practice. In melanoma, specific signatures have shown notable diagnostic, prognostic predictive value, with lineage-specific immune-related frequently identified markers. review, we explore role potential in highlight current status advances required translate therapeutic opportunities.

Language: Английский

Citations

0
Targeted miRNA Delivery in Epilepsy: Mechanisms, Advances, and Therapeutic Potential DOI

Mukul Shyam,

Oveyaa Bm,

Prathap Srirangan

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: April 7, 2025

Language: Английский

Citations

0
Exploring the Molecular Pathways of Advanced Rectal Cancer: A Focus on Genetic, RNA, and Biological Technique DOI

Ameeduzzafar Zafar,

Mohammad Khalid, Omar Awad Alsaidan

et al.

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: unknown, P. 155956 - 155956

Published: April 1, 2025

Language: Английский

Citations

0
CRISPR-Cas Systems: A Functional Perspective and Innovations DOI Open Access
Carla Navarro, María P. Díaz, Pablo Durán

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3645 - 3645

Published: April 12, 2025

Adaptation is a fundamental tenet of evolutionary biology and essential for the survival all organisms, including prokaryotes. The evolution clustered regularity exemplifies this principle interspaced short palindromic repeats (CRISPR) associated proteins (Cas), an adaptive immune system that confers resistance to viral infections. By integrating segments genomes into their own, bacteria archaea develop molecular memory enables them mount rapid targeted response upon subsequent challenges. fortuitous discovery mechanism prompted many studies introduced researchers novel tools could potentially be developed from CRISPR-Cas become clinically relevant as biotechnology rapidly advances in area. Thus, deeper understanding underpinnings its possible therapeutic applications required. This review analyses action systems detail summarises developing biotechnological based on CRISPR, opening field further research.

Language: Английский

Citations

0
Cascade CRISPR/Cas12a and DSN for the electrochemical biosensing of miR-1246 in BC-derived exosomes DOI

Xueqian Xiao,

Lina Tang, Chaoqing Li

et al.

Bioelectrochemistry, Journal Year: 2024, Volume and Issue: 159, P. 108753 - 108753

Published: May 31, 2024

Language: Английский

Citations

3
Advanced strategies of targeting circular RNAs as therapeutic approaches in colorectal cancer drug resistance DOI Creative Commons
Bashdar Mahmud Hussen, Snur Rasool Abdullah,

Abdulqahar Azizkhan Mohammed

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 260, P. 155402 - 155402

Published: June 14, 2024

Colorectal cancer (CRC) stands second in terms of mortality and third among the highest prevalent kinds globally. CRC prevalence is rising moderately poorly developed regions greater economically advanced regions. Despite breakthroughs targeted therapy, resistance to chemotherapeutics remains a significant challenge long-term management CRC. Circular RNAs (circRNAs) have been involved growing therapy resistance, particularly CRC, according an increasing number studies recent years. CircRNAs are one novel subclasses non-coding RNAs, previously thought as viroid. According studies, circRNAs recommended biological markers for therapeutic targets diagnostic prognostic purposes. That notable given that expression has linked hallmarks since they responsible drug patients; thereby, chemotherapy failure. Moreover, knowledge concerning relatively unclear despite using all these techniques. Here, this study, we will go over most published work highlight critical roles development main strategies overcome improve clinical outcomes.

Language: Английский

Citations

3