Synthesis of PVA-Based Hydrogels for Biomedical Applications: Recent Trends and Advances

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 88 - 88

Published: Jan. 23, 2025

There is ongoing research for biomedical applications of polyvinyl alcohol (PVA)-based hydrogels; however, the execution this has not yet been achieved at an appropriate level commercialization. Advanced perception necessary design and synthesis suitable materials, such as PVA-based hydrogel applications. Among polymers, drawn great interest in owing to their attractive potential with characteristics good biocompatibility, mechanical strength, apposite water content. By designing approach investigating structure, hydrogels can attain superb cytocompatibility, flexibility, antimicrobial activities, signifying that it a candidate tissue engineering regenerative medicine, drug delivery, wound dressing, contact lenses, other fields. In review, we highlight current progresses on explaining diverse usage across variety areas. We explain numerous techniques related phenomena based these materials. This review may stipulate wide reference future acumens materials extensive

Language: Английский

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The Role of Platelet Concentrates and Growth Factors in Facial Rejuvenation: A Systematic Review with Case Series

Medicina, Journal Year: 2025, Volume and Issue: 61(1), P. 84 - 84

Published: Jan. 7, 2025

Background and objectives: Due to the regeneration potential of growth factors (GFs) platelet concentrates (PCs), facial rejuvenation has been a major area attention in esthetic medicine. The effectiveness safety PCs GFs promoting face are examined this systematic review, which is complemented by case series. essential for collagen production dermal matrix remodeling, while PCs, like Platelet-Rich Plasma (PRP), abundant bioactive chemicals that promote tissue healing cellular regeneration. Materials Methods: A comprehensive literature search was performed on PubMed, Web Science, Scopus, focusing human clinical trials published between February 2019 2024 related PRP esthetics. Results: Thirteen studies met inclusion criteria were analyzed. Conclusions: review summarizes most recent data patient outcomes, treatment regimens, possible hazards. series goes with it shows real-world examples how improve skin elasticity, texture, general appearance little negative side effects. These results highlight use as minimally invasive procedures.

Language: Английский

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Mechanical biomimetic silk nano fiber-magnesium ion complex/hydroxyethylcellulose/glycerol hydrogel dressing with angiogenic capacity for accelerating scarless diabetic wound healing

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 667, P. 624 - 639

Published: April 9, 2024

Language: Английский

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Advances and applications of biomimetic biomaterials for endogenous skin regeneration

Bioactive Materials, Journal Year: 2024, Volume and Issue: 39, P. 492 - 520

Published: May 30, 2024

Endogenous regeneration is becoming an increasingly important strategy for wound healing as it facilitates skin's own regenerative potential self-healing, thereby avoiding the risks of immune rejection and exogenous infection. However, currently applied biomaterials inducing endogenous skin are simplistic in their structure function, lacking ability to accurately mimic intricate tissue regulate disordered microenvironment. Novel biomimetic with precise structure, chemical composition, biophysical properties offer a promising avenue achieving perfect regeneration. Here, we outline recent advances materials induced from aspects structural functional mimicry, physiological process regulation, property design. Furthermore, novel techniques including situ reprograming, flexible electronic skin, artificial intelligence, single-cell sequencing, spatial transcriptomics, which have contribute development highlighted. Finally, prospects challenges further research application discussed. This review provides reference address clinical problems rapid high-quality

Language: Английский

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Magnetic Nanoactuator-Protein Fiber Coated Hydrogel Dressing for Well-Balanced Skin Wound Healing and Tissue Regeneration

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Despite significant progress in skin wound healing, it is still a challenge to construct multifunctional bioactive dressings based on highly aligned protein fiber coated hydrogel matrix for antifibrosis regeneration that indistinguishable native skin. In this study, "dual-wheel-driven" strategy adopted modify the surface of methacrylated gelatin (GelMA) with magnetic nanocomposites-protein assemblies (MPF) consisting photothermal responsive antibacteria superparamagnetic nanocomposites-fibrinogen (Fg) complexes as building blocks. Whole-phase healing properties modified dressing, GelMA-MPF (GMPF), stem from integration Fg RGD peptide activity decorated antibacterial nanoactuator, facilitating facile and reproducible dressing preparation by self-assembly involving biochemical, morphological, biophysical cues. Payload substantial release copper ions

Language: Английский

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Flexible Sono–Piezo Patch for Functional Sweat Gland Repair through Endogenous Microenvironmental Remodeling

ACS Nano, Journal Year: 2024, Volume and Issue: 18(31), P. 20283 - 20295

Published: July 22, 2024

Remodeling the endogenous regenerative microenvironment in wounds is crucial for achieving scarless, functional tissue regeneration, especially recovery of skin appendages such as sweat glands burn patients. However, current approaches mostly rely on use exogenous materials or chemicals to stimulate cell proliferation and migration, while remodeling a pro-regenerative remains challenging. Herein, we developed flexible sono-piezo patch (fSPP) that aims create an promote repair wounds. This patch, composed multifunctional fibers with embedded piezoelectric nanoparticles, utilized low-intensity pulsed ultrasound (LIPUS) activate electrical stimulation target tissue, resulting enhanced behaviors niche tissues cells, including peripheral nerves, fibroblasts, vasculatures. We further demonstrated effective wound healing regeneration injuries solely through physical stimulation. noninvasive drug-free therapeutic approach holds significant potential clinical treatment injuries.

Language: Английский

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Exosomes from mesenchymal stem cells: Potential applications in wound healing

Life Sciences, Journal Year: 2024, Volume and Issue: 357, P. 123066 - 123066

Published: Sept. 19, 2024

Language: Английский

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Hemostatic Biopolymers: A Natural Approach for Revolutionizing Blood Loss Control

Polymer-Plastics Technology and Materials, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22

Published: Feb. 19, 2025

Language: Английский

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Multifunctional Tri-layer Wound Dressing containing ZnO nanoparticles and IGF-1 as an Efficient Biomaterial for Healing of Full Thickness Skin Injuries

Asian Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 101039 - 101039

Published: Feb. 1, 2025

Language: Английский

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A highly transparent dopamine-copolymerized hydrogel with enhanced ROS-scavenging and tissue-adhesive properties for chronic diabetic wounds

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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