Manipulated mesenchymal stem cell therapy in the treatment of Parkinson’s disease DOI Creative Commons

Seyedeh Toktam Ekrani,

Mahmoud Mahmoudi, Dariush Haghmorad

et al.

Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 18, 2024

Mesenchymal stem cell (MSC) therapy has been considered a promising approach for the treatment of Parkinson's disease (PD) several years. PD is globally prevalent neurodegenerative characterized by accumulation Lewy bodies and loss dopaminergic neurons, leading to severe motor non-motor complications in patients. As current treatments are unable halt progression neuronal dopamine degradation, MSC emerged as highly strategy treatment. This promise due MSCs' unique properties compared other types cells, including self-renewal, differentiation potential, immune privilege, secretion neurotrophic factors, ability improve damaged tissue, modulation system, lack ethical concerns. MSCs have employed numerous pre-clinical clinical studies with results. However, certain aspects their efficacy treating may benefit from various genetic epigenetic modifications. In this review article, we assess these approaches improving specialized PD.

Language: Английский

Hypoxia and aging: molecular mechanisms, diseases, and therapeutic targets DOI Creative Commons
Ayesha Nisar,

Sawar Khan,

Wen Li

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(11)

Published: Oct. 15, 2024

Abstract Aging is a complex biological process characterized by the gradual decline of cellular functions, increased susceptibility to diseases, and impaired stress responses. Hypoxia, defined as reduced oxygen availability, critical factor that influences aging through molecular pathways involving hypoxia‐inducible factors (HIFs), oxidative stress, inflammation, epigenetic modifications. This review explores interconnected roles hypoxia in aging, highlighting how hypoxic conditions exacerbate damage, promote senescence, contribute age‐related pathologies, including cardiovascular neurodegenerative disorders, cancer, metabolic dysfunctions, pulmonary conditions. By examining mechanisms linking we identify key serve potential therapeutic targets. Emerging interventions such HIF modulators, antioxidants, senolytics, lifestyle modifications hold promise mitigating adverse effects on tissues. However, challenges heterogeneity lack reliable biomarkers, safety concerns regarding hypoxia‐targeted therapies remain. emphasizes need for personalized approaches advanced technologies develop effective antiaging interventions. integrating current knowledge, this provides comprehensive framework underscores importance targeting hypoxia‐induced enhance healthy reduce burden diseases.

Language: Английский

Citations

4
Dietary Natural Melanin Nanozymes Delay Aging and Ameliorate Neurodegeneration via Improving Gut Microbiota and Redox Homeostasis DOI Creative Commons
Yao Xiao, Shikun Zhang,

Hailong Zhuo

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: 10(4), P. 3610 - 3621

Published: Jan. 22, 2025

Aging is an inevitable multifactor process that causes a decline in organ function and increases the risk of age-related diseases death. Thus, development highly effective safe therapeutic strategies to delay aging urgently required. In this study, we isolated natural melanin nanozymes (NMNs) from ink sacs live octopuses. The NMNs exhibited excellent superoxide-dismutase-mimicking radical scavenging activities. SAMP8 mice, treatment with improved their cognition memory functions while restoring aging-impaired liver lipid metabolism, thereby prolonging lifespan. Moreover, reversed metabolic changes aged brains reconstructed gut microbiota composition by enhancing microbial community diversity. Our findings indicate could be promising approach for delaying preventing age-associated physiological humans.

Language: Английский

Citations

0
Advances in neural stem cells in aging and age-related neurodegenerative diseases DOI Open Access
Rujia Zhong, Wenhao Huang, Chao Chen

et al.

Ageing and Neurodegenerative Diseases, Journal Year: 2025, Volume and Issue: 5(1)

Published: Jan. 26, 2025

With aging, neural stem cells (NSCs) undergo age-related changes, including metabolic abnormalities, disrupted protein homeostasis, mitochondrial dysfunction, reduced genetic stability, and more notably, a diminished capacity for proliferation differentiation. These changes may contribute to the development of neurodegenerative diseases such as Alzheimer’s disease (AD) Parkinson’s (PD). In these conditions, disease-specific pathological interact with alterations NSCs, resulting in impairment neurogenesis, which further leads cognitive, mood, motor decline. Based on potential therapeutics targeting neurogenesis cell-based therapies restore functions NSCs replace degenerated neurons, aiming ameliorate functional decline diseases. While therapies, cell transplantation secretome therapy, show great treatment diseases, challenges tumorigenesis, immune rejection, extraction or storage need be addressed. A better understanding age- disease-related underlying mechanism driving benefits drawbacks therapeutic approaches provide insights novel disease-modifying interventions future

Language: Английский

Citations

0
Olfactory mucosal mesenchymal stem cell-derived exosome Lnc A2M-AS1 ameliorates oxidative stress by regulating TP53INP1-mediated mitochondrial autophagy through interacting with IGF2BP1 in Parkinson’s diseases DOI Creative Commons
Jiangshan Zhang, Chuang Wang, Guoshuai Yang

et al.

Cell Biology and Toxicology, Journal Year: 2025, Volume and Issue: 41(1)

Published: March 20, 2025

Abstract Background Exosome Lnc A2M-AS1 from olfactory mucosa mesenchymal stem cells (OM-MSCs) can ameliorate oxidative stress by improving mitophagy in cardiomuscular cells; however, it remains unclear whether this effect exists the brain tissues of patients with Parkinson’s disease (PD). Methods OM-MSC–Exosomes were isolated and verified based on morphology specific biomarkers. The effects OM-MSC-Exo mitochondrial autophagy, stress, lncRNA detected MPP + -treated HT22 cells. OM-MSC-Exos autophagy an MPTP-induced Parkinson's (PD) model C57BL/6 mice. interaction between IGF2BP1, A2M-AS1, TP53INP1 was assessed via RNA pull-down/RNA Immunoprecipitation stability assays. lnc IGF2BP1/TP53INP1-mediated PD mouse models. Results Exosomes found to be rich A2M-AS1. proved able induced regulates enhancing In addition, through mediated expression binding IGF2BP1. Furthermore, treatment improved symptoms ameliorated Conclusion Collectively, OM-MSC-derived exosomes targeting IGF2BP1 induce stress. could potentially serve as promising candidates for new methods PD. Graphical

Language: Английский

Citations

0
Redox modulatory role of DJ-1 in Parkinson’s disease DOI
Qamar A. Alshammari

Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)

Published: March 30, 2025

Language: Английский

Citations

0
Neurodegenerative disorders: A Holistic study of the explainable artificial intelligence applications DOI Creative Commons
Hongyuan Wang, Shiva Toumaj, Arash Heidari

et al.

Engineering Applications of Artificial Intelligence, Journal Year: 2025, Volume and Issue: 153, P. 110752 - 110752

Published: April 18, 2025

Language: Английский

Citations

0
The Cooperation of Neurogranin with Calmodulin Promotes the Treatment of Aging-Related Diseases via Regular Exercise DOI

Hosniyeh Rajavand,

Vahideh Zalouli,

Zeinab Nematollahi

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

Language: Английский

Citations

0
Advances in the roles and mechanisms of mesenchymal stem cell derived microRNAs on periodontal tissue regeneration DOI Creative Commons
Jiaxiang Zhang,

Liangrui Chen,

Jialu Yu

et al.

Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)

Published: Nov. 3, 2024

Periodontitis is one of the most prevalent oral diseases leading to tooth loss in adults, and characterized by destruction periodontal supporting structures. Traditional therapies for periodontitis cannot achieve ideal regeneration tissue. Mesenchymal stem cells (MSCs) represent a promising approach tissue regeneration. Recently, prominent role MSCs this context has been attributed microRNAs (miRNAs), which participate post-transcriptional regulation are crucial various physiological pathological processes. Additionally, they function as indispensable elements extracellular vesicles, protect them from degradation. In periodontitis, MSCs-derived miRNAs play pivotal cellular proliferation differentiation, angiogenesis tissues, regulating autophagy, providing anti-apoptotic effects, mediating inflammatory microenvironment. As cell-free strategy, their small size ability target related sets genes regulate signaling networks predispose become candidates This review aims introduce summarize potential functions mechanisms repair

Language: Английский

Citations

1
A cognitive few-shot learning for medical diagnosis: A case study on cleft lip and palate and Parkinson’s disease DOI
Pei Yin, Junjie Song, Yassine Bouteraa

et al.

Expert Systems with Applications, Journal Year: 2024, Volume and Issue: 262, P. 125713 - 125713

Published: Nov. 4, 2024

Language: Английский

Citations

1
Manipulated mesenchymal stem cell therapy in the treatment of Parkinson’s disease DOI Creative Commons

Seyedeh Toktam Ekrani,

Mahmoud Mahmoudi, Dariush Haghmorad

et al.

Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 18, 2024

Mesenchymal stem cell (MSC) therapy has been considered a promising approach for the treatment of Parkinson's disease (PD) several years. PD is globally prevalent neurodegenerative characterized by accumulation Lewy bodies and loss dopaminergic neurons, leading to severe motor non-motor complications in patients. As current treatments are unable halt progression neuronal dopamine degradation, MSC emerged as highly strategy treatment. This promise due MSCs' unique properties compared other types cells, including self-renewal, differentiation potential, immune privilege, secretion neurotrophic factors, ability improve damaged tissue, modulation system, lack ethical concerns. MSCs have employed numerous pre-clinical clinical studies with results. However, certain aspects their efficacy treating may benefit from various genetic epigenetic modifications. In this review article, we assess these approaches improving specialized PD.

Language: Английский

Citations

0