A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, 8-Week Pilot Study of Tuna-Byproduct-Derived Novel Supplements for Managing Cellular Senescence and Cognitive Decline in Perimenopausal and Postmenopausal Women
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(5), P. 520 - 520
Published: April 27, 2025
Due
to
the
lack
of
clinical
data,
we
aimed
assess
anti-cellular
senescence
and
cognition-enhancing
effects
mechanisms
novel
tuna-byproduct-derived
supplements.
An
8-week,
three-arm,
randomized,
double-blind,
placebo-controlled
parallel
study
was
performed.
A
total
60
female
perimenopausal
postmenopausal
women
(45–60
years
old)
were
randomly
assigned
placebo,
low
(2600
mg/day),
high
(6000
mg/day)
doses
supplement.
The
N100
P300
brain
waves,
working
memory,
serum
levels
MDA,
SOD,
CAT,
GPx
TNF-α,
IL-6,
eNOS,
AChE,
MAO,
GABA-T,
SIRT1,
density
Lactobacillus
Bifidobacterium
spp.
in
feces
assessed
before
consumption
every
4
weeks
throughout
period.
telomere
length
phenolic
compound
DHA
at
end
study.
dose
increased
amplitude,
length,
whereas
improved
amplitudes
N00
P300,
latency,
memory;
suppressed
GABA-T;
GPx,
IL-6
serum,
further
exhibiting
an
increase
DHA.
Therefore,
supplement
could
be
a
potential
remedy
for
managing
cellular
cognitive
decline
women;
however,
studies
with
larger
sample
sizes
are
required.
Language: Английский
Mung Bean Functional Protein Enhances Endothelial Function via Antioxidant Activity and Inflammation Modulation in Middle-Aged Adults: A Randomized Double-Blind Trial
Foods,
Journal Year:
2024,
Volume and Issue:
13(21), P. 3427 - 3427
Published: Oct. 28, 2024
This
study
examines
the
impact
of
mung
bean
(Vigna
radiata)
protein
consumption
on
endothelial
function
in
middle-aged
adults,
focusing
antioxidant
enzyme
activity
and
anti-inflammatory
markers.
Mung
beans
have
shown
promise
enhancing
cardiovascular
function,
lowering
blood
pressure,
improving
lipid
profiles,
but
underlying
mechanisms
these
functions
remain
unclear.
Conducted
as
a
three-arm
randomized,
double-blind,
placebo-controlled
trial,
this
involved
male
female
participants
aged
45
to
60
assigned
them
consume
either
placebo
or
functional
drink
containing
10
15
g
daily
for
six
weeks.
Vasodilation
was
assessed
using
flow-mediated
dilation
(FMD),
oxidative
stress
markers,
activity,
inflammatory
markers
were
measured
at
baseline
after
intervention.
The
results
indicate
that
weeks
significantly
benefits
healthy
adults
by
reducing
mediators’
expression.
Additionally,
increase
brachial
artery
diameter
following
FMD
indicates
improved
function.
Language: Английский
Association Between Weight-Adjusted Waist Index and Emphysema in Adults in the United States: A Cross-Sectional Study Involving 44,949 Participants
Advances in respiratory medicine,
Journal Year:
2024,
Volume and Issue:
92(6), P. 472 - 484
Published: Nov. 21, 2024
Background:
The
relationship
between
obesity
and
respiratory
diseases
has
been
widely
explored.
In
this
context,
the
Weight-Adjusted
Waist
Index
(WWI)
emerged
as
a
novel
metric
for
assessing
visceral
fat.
This
study
aims
to
evaluate
association
WWI
risk
of
emphysema
in
U.S.
population,
by
utilizing
data
from
2001–2018
National
Health
Nutrition
Examination
Survey
(NHANES).
Methods:
A
cross-sectional
was
conducted
using
NHANES
2001
2018.
Logistic
regression
models
were
applied
assess
risk.
Interaction
subgroup
analyses
performed
explore
effect
modifiers.
Results:
Our
included
total
44,949
American
adults.
results
multivariable
logistic
analysis
revealed
an
incidence
emphysema.
fully
adjusted
model,
probability
developing
1.5
times
higher
group
with
>
10.46
compared
those
≤
10.46,
odds
ratio
[1.5
(1.1,
1.9),
p
=
0.003].
Subgroup
showed
stronger
associations
among
males,
non-Hispanic
Whites,
individuals
hypertension.
Furthermore,
we
used
two-piece
linear
model
found
nonlinear
emphysema,
breakpoint
at
12.5.
Conclusions:
findings
indicate
significant
levels
Larger-scale
prospective
studies
are
needed
further
role
Language: Английский