Journal of Tissue Engineering,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 1, 2024
Neuropathic
pain
(NP)
is
a
debilitating
condition
stemming
from
damage
to
the
somatosensory
system
frequently
caused
by
nerve
injuries
or
lesions.
While
existing
treatments
are
widely
employed,
they
often
lead
side
effects
and
lack
specificity.
This
study
aimed
alleviate
NP
developing
an
innovative
sustained-release
thermosensitive
hydrogel
system.
The
incorporates
hyaluronic
acid
(HA)/Pluronic
F127
injectable
bupivacaine
(Bup,
B)
in
combination
with
poly(lactic-co-glycolic
acid;
PLGA)/modified
magnesium
hydroxide
(MH)/luteolin
(Lut;
PML)
microspheres
(PML@B/Gel).
PML@B/Gel
was
designed
for
localized
prolonged
co-delivery
of
Bup
Lut
as
anesthetic
anti-inflammatory
agent,
respectively.
Our
studies
demonstrated
that
had
exceptional
biocompatibility,
anti-inflammatory,
antioxidant
properties.
In
addition,
it
exhibited
efficient
relief
vitro
cellular
assays.
Moreover,
this
functional
showed
substantial
sustained
drug
release
while
diminishing
microglial
activation.
Consequently,
effectively
mitigated
mechanical
allodynia
thermal
hyperalgesia
vivo
rat
models
chronic
constriction
injury
(CCI).
Based
on
our
research
findings,
emerges
promising
therapeutic
approach
protracted
treatment
NP.
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 18, 2025
Wound
healing
is
a
complex
and
dynamic
process
of
replacing
missing
cellular
structures
tissue
layers.
Clinical
practice
includes
the
application
sterile
bandage
to
promote
restrain
infection,
like
commercial
nonbiodegradable
meshes.
However,
while
inert,
nontoxic,
nonimmunogenic,
they
can
cause
calcification,
fibrosis,
inflammation,
potentially
hindering
in
long
term.
To
address
this
challenge
enhance
wound
healing,
we
developed
totally
biodegradable
electrospun
poly(d,l-lactide-co-ε-caprolactone)
(PDLLCL)
drug
delivery
system
that
incorporates
two
already
FDA-approved
antifibrotics,
pirfenidone
(PIRF)
triamcinolone
acetonide
(TA).
The
PDLLCL
meshes,
fabricated
via
electrospinning,
exhibited
homogeneity
complete
degradation
after
120
days,
consistent
with
process.
In
vitro,
functional
analysis
on
RAW
264.7
macrophages
revealed
no
cytotoxicity
an
immunomodulatory
effect
PIRF
TA
compared
positive
control
(lipopolysaccharides,
LPS)
meshes
alone.
Lastly,
subcutaneous
vivo
assessment
rabbit
model,
following
ISO
10993-6
standard,
showed
our
tailored
made
were
able
lower
both
irritation
fibrosis
indexes
from
2
weeks
4
implantation,
highlighting
beneficial
polymers.
saw
significant
incorporation
antifibrotics
for
indexes.
This
underscores
potential
as
possible
alternative
reducing
use
intermittent
antifibrotic
agents
during
Journal of Tissue Engineering,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 1, 2024
Neuropathic
pain
(NP)
is
a
debilitating
condition
stemming
from
damage
to
the
somatosensory
system
frequently
caused
by
nerve
injuries
or
lesions.
While
existing
treatments
are
widely
employed,
they
often
lead
side
effects
and
lack
specificity.
This
study
aimed
alleviate
NP
developing
an
innovative
sustained-release
thermosensitive
hydrogel
system.
The
incorporates
hyaluronic
acid
(HA)/Pluronic
F127
injectable
bupivacaine
(Bup,
B)
in
combination
with
poly(lactic-co-glycolic
acid;
PLGA)/modified
magnesium
hydroxide
(MH)/luteolin
(Lut;
PML)
microspheres
(PML@B/Gel).
PML@B/Gel
was
designed
for
localized
prolonged
co-delivery
of
Bup
Lut
as
anesthetic
anti-inflammatory
agent,
respectively.
Our
studies
demonstrated
that
had
exceptional
biocompatibility,
anti-inflammatory,
antioxidant
properties.
In
addition,
it
exhibited
efficient
relief
vitro
cellular
assays.
Moreover,
this
functional
showed
substantial
sustained
drug
release
while
diminishing
microglial
activation.
Consequently,
effectively
mitigated
mechanical
allodynia
thermal
hyperalgesia
vivo
rat
models
chronic
constriction
injury
(CCI).
Based
on
our
research
findings,
emerges
promising
therapeutic
approach
protracted
treatment
NP.
