The Role of Lipid Metabolism in Gastric Cancer DOI Creative Commons
Mengying Cui, Xing Yi, Danxia Zhu

et al.

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: June 15, 2022

Gastric cancer has been one of the most common cancers worldwide with extensive metastasis and high mortality. Chemotherapy found as a main treatment for metastatic gastric cancer, whereas drug resistance limits effectiveness chemotherapy leads to failure. in complex multifactorial mechanism, among which lipid metabolism plays vital role. Increased synthesis new lipids or uptake exogenous can facilitate rapid growth cells tumor formation. Lipids form structural basis biofilms while serving signal molecules energy sources. It is noteworthy that capable inducing by reshaping micro-environment. In this study, mechanisms metabolic pathways correlated are reviewed. particular, we discuss effects on autophagy, biomarkers from perspective metabolism. brief, insights be gained into development promising therapies through an in-depth investigation mechanism reprogramming resensitization cells, scientific provided applying lipid-key enzyme inhibitors chemical sensitizers clinical settings.

Language: Английский

Collagen Type XI Alpha 1 (COL11A1): A Novel Biomarker and a Key Player in Cancer DOI Open Access
Sameera Nallanthighal,

James Patrick Heiserman,

Dong‐Joo Cheon

et al.

Cancers, Journal Year: 2021, Volume and Issue: 13(5), P. 935 - 935

Published: Feb. 24, 2021

Collagen type XI alpha 1 (COL11A1), one of the three chains collagen, is crucial for bone development and collagen fiber assembly. Interestingly, COL11A1 expression increased in several cancers high levels are often associated with poor survival, chemoresistance, recurrence. This review will discuss recent discoveries biological functions cancer. predominantly expressed secreted by a subset cancer-associated fibroblasts, modulating tumor-stroma interaction mechanical properties extracellular matrix. also promotes cancer cell migration, metastasis, therapy resistance activating pro-survival pathways tumor metabolic phenotype. Several inhibitors that currently being tested clinical trials or used clinic other diseases, can be potentially to target signaling. Collectively, this underscores role as promising biomarker key player

Language: Английский

Citations

87
New insights into molecules and pathways of cancer metabolism and therapeutic implications DOI Creative Commons

Zhenye Tang,

Zhenhua Xu, Xiao Zhu

et al.

Cancer Communications, Journal Year: 2020, Volume and Issue: 41(1), P. 16 - 36

Published: Nov. 10, 2020

Cancer cells are abnormal that can reproduce and regenerate rapidly. They characterized by unlimited proliferation, transformation migration, destroy normal cells. To meet the needs for cell proliferation tumor acquire molecular materials energy through unusual metabolic pathways as their metabolism is more vigorous than of Multiple carcinogenic signaling eventually converge to regulate three major in cells, including glucose, lipid, amino acid metabolism. The distinct signatures cancer reflect changes indispensable genesis development In this review, we report unique alterations which occur various axes, present modalities available diagnosis clinical therapy. We further provide suggestions anti-tumor therapeutic drugs.

Language: Английский

Citations

84
Inhibition of fatty acid catabolism augments the efficacy of oxaliplatin-based chemotherapy in gastrointestinal cancers DOI Creative Commons
Yun Wang,

Jiahuan Lu,

Feng Wang

et al.

Cancer Letters, Journal Year: 2020, Volume and Issue: 473, P. 74 - 89

Published: Jan. 2, 2020

Gastrointestinal cancer causes countless deaths every year due to therapeutic resistance. However, whether metabolic alterations contribute chemoresistance is not well understood. In this study, we report that fatty acid (FA) catabolism was activated in gastrointestinal cells treated with oxaliplatin, which exhibited higher expression of the rate-limiting enzymes carnitine palmitoyltransferase 1B (CPT1B) and CPT2. The clinical analysis also showed high these associated poor oxaliplatin-based chemotherapy outcomes patients. Furthermore, genetic or pharmacological inhibition CPT2 perhexiline disturbed NADPH redox homeostasis increased reactive oxygen species (ROS) generation cell apoptosis following oxaliplatin treatment. Specifically, combination significantly suppressed progression cell-based xenograft patient-derived (PDX) models. Mechanistically, transcriptionally upregulated by nuclear factor T 3 (NFATc3), translocated nucleus response summary, our study suggests CPT-mediated FA combined conventional a promising strategy for patients cancers.

Language: Английский

Citations

76
The emerging role of targeting cancer metabolism for cancer therapy DOI Creative Commons

Pegah Farhadi,

Reza Yarani, Sadat Dokaneheifard

et al.

Tumor Biology, Journal Year: 2020, Volume and Issue: 42(10), P. 101042832096528 - 101042832096528

Published: Oct. 1, 2020

Glucose, as the main consuming nutrient of body, faces different destinies in cancer cells. Glycolysis, oxidative phosphorylation, and pentose phosphate pathways produce glucose-derived metabolites thus affect cells’ bioenergetics differently. Tumor dependency to aerobic glycolysis other cancer-specific metabolism changes are known hallmarks, distinct cells from normal Therefore, these tumor-specific characteristics receive limelight targets for therapy. Glutamine, serine, fatty acid oxidation together with 5-lipoxygenase that have attracted lots attention In this review, we not only discuss tumor aspects but also roles promotion at stages their difference Besides, dissect inhibitors potential blocking metabolic introduce effective non-effective field.

Language: Английский

Citations

74
Redox Homeostasis and Metabolism in Cancer: A Complex Mechanism and Potential Targeted Therapeutics DOI Open Access

Alia Ghoneum,

Ammar Yasser Abdulfattah,

Bailey Warren

et al.

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(9), P. 3100 - 3100

Published: April 28, 2020

Reactive Oxygen Species or “ROS” encompass several molecules derived from oxygen that can oxidize other and subsequently transition rapidly between species. The key roles of ROS in biological processes are cell signaling, biosynthetic processes, host defense. In cancer cells, increased production oxidative stress instigated by carcinogens, oncogenic mutations, importantly, metabolic reprograming the proliferating cells. Increased activates myriad downstream survival pathways further progression metastasis. this review, we highlight relation ROS, programing cancer, stromal immune cells with emphasis on transcription machinery involved redox homeostasis, malignant phenotype. We also shed light therapeutic targeting generating as investigate: Orlistat, Biguandes, AICAR, 2 Deoxyglucose, CPI-613, Etomoxir.

Language: Английский

Citations

73
Obesity promotes radioresistance through SERPINE1-mediated aggressiveness and DNA repair of triple-negative breast cancer DOI Creative Commons
Yong-Han Su, Yi‐Zhen Wu, David K. Ann

et al.

Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(1)

Published: Jan. 21, 2023

Obesity is a risk factor in various types of cancer, including breast cancer. The disturbance adipose tissue obesity highly correlates with cancer progression and resistance to standard treatments such as chemo- radio-therapies. In this study, syngeneic mouse model triple-negative (TNBC), diet-induced (DIO) not only promoted tumor growth, but also reduced response radiotherapy. Serpine1 (Pai-1) was elevated the circulation obese mice enriched within microenvironment. vitro co-culture human white adipocytes-conditioned medium (hAd-CM) TNBC cells potentiated aggressive phenotypes radioresistance cells. Moreover, inhibition both cell autonomous non-autonomous SERPINE1 by either genetic or pharmacological strategy markedly dampened Mechanistically, we uncovered previously unrecognized role DNA damage response. Ionizing radiation-induced double-strand breaks (DSBs) increased expression an ATM/ATR-dependent manner, nuclear localization facilitate DSB repair. By analyzing public clinical datasets, higher correlated patients' BMI well poor outcomes. Elevated were observed radioresistant Collectively, reveal link between identify be crucial mediating obesity-associated radioresistance.

Language: Английский

Citations

29
Targeting Mitochondrial Metabolic Reprogramming as a Potential Approach for Cancer Therapy DOI Open Access

Liufeng Zhang,

Yuancheng Wei,

Shengtao Yuan

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4954 - 4954

Published: March 4, 2023

Abnormal energy metabolism is a characteristic of tumor cells, and mitochondria are important components metabolic reprogramming. Mitochondria have gradually received the attention scientists due to their functions, such as providing chemical energy, producing substrates for anabolism, controlling REDOX calcium homeostasis, participating in regulation transcription, cell death. Based on concept reprogramming mitochondrial metabolism, range drugs been developed target mitochondria. In this review, we discuss current progress summarized corresponding treatment options. Finally, propose inner membrane transporters new feasible therapeutic targets.

Language: Английский

Citations

25
Targeting FABP4/UCP2 axis to overcome cetuximab resistance in obesity-driven CRC with drug-tolerant persister cells DOI Creative Commons
Yi‐Chiao Cheng, Ming‐Yao Chen, Vijesh Kumar Yadav

et al.

Translational Oncology, Journal Year: 2025, Volume and Issue: 53, P. 102274 - 102274

Published: Jan. 18, 2025

Language: Английский

Citations

1
Cancer cell reprogramming: a promising therapy converting malignancy to benignity DOI Creative Commons
Lanqi Gong, Qian Yan, Yu Zhang

et al.

Cancer Communications, Journal Year: 2019, Volume and Issue: 39(1), P. 1 - 13

Published: Aug. 29, 2019

Abstract In the past decade, remarkable progress has been made in reprogramming terminally differentiated somatic cells and cancer into induced pluripotent with benign phenotypes. Recent studies have explored various approaches to induce from one cell type another, including lineage‐specific transcription factors‐, combinatorial small molecules‐, microRNAs‐ embryonic microenvironment‐derived exosome‐mediated reprogramming. These proven be technically feasible versatile enable re‐activation of sequestered epigenetic regions, thus driving fate decisions cells. One significant utilities is therapeutic potential retrieving normal functions malignancies. However, there are several major obstacles overcome before clinical translation, characterization mechanisms, improvement efficiency safety, development delivery methods. Recently, insights mechanism proposed, determining achieved promote feasibility, allowing it emerge as a promising therapy against near future. This review aims discuss recent applications reprogramming, focus on significance limitations different approaches, while summarizing vital roles played by factors, molecules, microRNAs exosomes during process.

Language: Английский

Citations

70
Obesity and Cancer Metastasis: Molecular and Translational Perspectives DOI Open Access
Stephanie Annett, Gillian Moore, Tracy Robson

et al.

Cancers, Journal Year: 2020, Volume and Issue: 12(12), P. 3798 - 3798

Published: Dec. 16, 2020

Obesity is a modern health problem that has reached pandemic proportions. It an established risk factor for carcinogenesis, however, evidence the contribution of adipose tissue to metastatic behavior tumors also mounting. Over 90% cancer mortality attributed metastasis and tumor cells must communicate with their microenvironment survival. Many characteristics observed in obese strongly mirror microenvironment. Thus case prostate, pancreatic breast esophageal adenocarcinoma, which are all located close anatomical proximity depot, adjacent fat provides ideal enhance growth, progression metastasis. Adipocytes provide adipokines, fatty acids other soluble factors whilst immune infiltrate In addition, there emerging studies on role extracellular vesicles secreted from tissue, matrix itself, as drivers obesity-induced present review, we discuss major mechanisms responsible obesity–metastatic link. Furthermore, understanding these complex will novel therapies halt tumor–adipose crosstalk ultimate aim inhibiting growth.

Language: Английский

Citations

66