Zinc or/and Vitamin E Supplementation Mitigates Oxidative Stress, Neuroinflammation, Neurochemical Changes and Behavioural Deficits in Male Wistar Rats Exposed to Bonny Light Crude Oil DOI Creative Commons
Oluwafunmbi Ebenezer Ogunmiluyi,

A Naiho,

Victor Emojevwe

et al.

Journal of Toxicology, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Background: Crude oil, a major key economic driver in developing countries, is also of environmental concern, linked to neurotoxicity and behavioural problems. Despite the known neurotoxic effects crude oil potential benefits zinc vitamin E, there paucity research specifically addressing their combined efficacy mitigating neurochemical changes deficits induced by oil. Current studies have largely focussed on individual these supplements different contexts, but synergistic exposure model remains underexplored. This study investigated E neurobehavioural alterations male Wistar rats fed with Bonny light (BLCO)‐contaminated diet. Methods: Thirty (30) (160 ± 10 g) were assigned into five groups ( n = 6). Group 1 received standard rat feed, 2 was exposed BLCO (0.1 mL/g feed) for 3 weeks, 3–5 treated (50 mg/kg/day), (400 IU/kg), or both [vitamin IU/kg) + mg/kg/day)], respectively week after weeks. Locomotive, anxiolytic, depressive‐like behaviours spatial memory assessed using open‐field test, elevated plus maze, forced swim test Y‐maze. Rats sacrificed brain samples collected biochemical assays at end tests. Results: Zinc supplementation (individually combined) significantly increased total antioxidant capacity superoxide dismutase (SOD) activity, reduced inflammatory markers (TNF‐alpha) lipid peroxidation, normalized neurotransmitter levels improved performance. Conclusion: Treatment Zn and/or reverses BLCO‐induced via modulation oxidative stress, inflammation neurotransmitters.

Language: Английский

Humic Acid Derived from Vermicompost Improves Bone Mineral Content and Alters Oxidative Stress Markers in Ovariectomized Mice DOI Creative Commons
Thays Cristina dos Santos,

H. Silva,

Karen Rodrigues Lima

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 495 - 495

Published: Feb. 17, 2025

Background: Estrogen depletion alters bone mineralization and oxidative stress. Antioxidants like humic acids (HA) may help mitigate demineralization redox imbalances. Thus, this study evaluated the effects of HA on mineral composition stress markers in an experimental menopause model. Methods: Twenty-four female C57BL/6 mice were divided into four groups (n = 6/group): Sham; Sham + HA; Ovariectomized (OVX); OVX HA. The model was induced by bilateral ovariectomy at beginning experiment. derived from biomass vermicompost administered daily gavage for 28 days. After euthanasia, femurs fragments gastrocnemius muscle, liver, kidney collected. Bone elemental analyzed using scanning electron microscopy (SEM) coupled with energy dispersive spectroscopy (EDS). Superoxide dismutase (SOD), catalase (CAT), hydrogen peroxide (H2O2) activities assessed renal, hepatic tissues. Data two-way ANOVA Bonferroni's post hoc test. Results: Untreated exhibited a significant reduction femoral calcium content (p < 0.05). However, treatment increased levels improved Ca/P ratio H2O2 activity reduced liver compared to untreated animals CAT muscle group Conclusions: modulated

Language: Английский

Citations

0
Zinc or/and Vitamin E Supplementation Mitigates Oxidative Stress, Neuroinflammation, Neurochemical Changes and Behavioural Deficits in Male Wistar Rats Exposed to Bonny Light Crude Oil DOI Creative Commons
Oluwafunmbi Ebenezer Ogunmiluyi,

A Naiho,

Victor Emojevwe

et al.

Journal of Toxicology, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Background: Crude oil, a major key economic driver in developing countries, is also of environmental concern, linked to neurotoxicity and behavioural problems. Despite the known neurotoxic effects crude oil potential benefits zinc vitamin E, there paucity research specifically addressing their combined efficacy mitigating neurochemical changes deficits induced by oil. Current studies have largely focussed on individual these supplements different contexts, but synergistic exposure model remains underexplored. This study investigated E neurobehavioural alterations male Wistar rats fed with Bonny light (BLCO)‐contaminated diet. Methods: Thirty (30) (160 ± 10 g) were assigned into five groups ( n = 6). Group 1 received standard rat feed, 2 was exposed BLCO (0.1 mL/g feed) for 3 weeks, 3–5 treated (50 mg/kg/day), (400 IU/kg), or both [vitamin IU/kg) + mg/kg/day)], respectively week after weeks. Locomotive, anxiolytic, depressive‐like behaviours spatial memory assessed using open‐field test, elevated plus maze, forced swim test Y‐maze. Rats sacrificed brain samples collected biochemical assays at end tests. Results: Zinc supplementation (individually combined) significantly increased total antioxidant capacity superoxide dismutase (SOD) activity, reduced inflammatory markers (TNF‐alpha) lipid peroxidation, normalized neurotransmitter levels improved performance. Conclusion: Treatment Zn and/or reverses BLCO‐induced via modulation oxidative stress, inflammation neurotransmitters.

Language: Английский

Citations

0