Engineering exosomes for mRNA delivery: a review DOI
Ting Yao,

X Dong,

Xinyu Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 144662 - 144662

Published: May 1, 2025

Language: Английский

Novel gene manipulation approaches to unlock the existing bottlenecks of CAR-NK cell therapy DOI Creative Commons

Fatemeh Dehghan,

Yekta Metanat,

Mandana Askarizadeh

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 11, 2025

Currently, CAR-T cell therapy is known as an efficacious treatment for patients with relapsed/refractory hematologic malignancies. Nonetheless, this method faces several bottlenecks, including low efficacy solid tumors, lethal adverse effects, high cost of autologous products, and the risk GvHD in allogeneic settings. As a potential alternative, CAR-NK can overcome most limitations provide off-the-shelf, safer, more affordable product. Although published results from preclinical clinical studies cells are promising, bottlenecks must be unlocked to maximize effectiveness therapy. These include vivo persistence, trafficking into tumor sites, modest sensitivity immunosuppressive microenvironment. In recent years, advances gene manipulation tools strategies have laid groundwork current This review will introduce existing discuss their advantages disadvantages. We also explore how these enhance therapy’s safety efficacy.

Language: Английский

Citations

3
Exosomes in review: A new frontier in CAR-T cell therapies DOI
Jiguang Wang,

Samuel J Schellenberg,

Athena Demeros

et al.

Neoplasia, Journal Year: 2025, Volume and Issue: 62, P. 101147 - 101147

Published: March 3, 2025

Language: Английский

Citations

1
The paths toward immunotherapy of esophageal cancer: An overview of clinical trials DOI
Azfar Jamal,

Allolo D Aldreiwish,

Saeed Banawas

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 151, P. 114261 - 114261

Published: Feb. 26, 2025

Language: Английский

Citations

0
Harnessing Exosomes: From Tumor Immune Escape to Therapeutic Innovation in Gastric Cancer Immunotherapy DOI

Zhao Jin,

Cheng Zhang, Lin Shen

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217792 - 217792

Published: May 1, 2025

Language: Английский

Citations

0
Precision exosome engineering for enhanced wound healing and scar revision DOI Creative Commons
Chuanqi Liu, Cheng Chen, Kun Cheng

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 23, 2025

The dysfunction of wound-healing processes can result in chronic non-healing wounds and pathological scar formation. Current treatment options often fall short, necessitating innovative approaches. Exosomes, extracellular vesicles secreted by various cells, have emerged as promising therapeutic agents serving an intercellular communication system. By engineering exosomes, their cargo surface properties be tailored to enhance efficacy specificity. Engineered exosomes (eExo) are emerging a favorable tool for treating scars. In this review, we delve into the underlying mechanisms scars, outline current state strategies, explore clinical potential eExo based on preclinical studies. addition, address challenges future research directions, including standardization, safety assessments, immune responses. conclusion, hold great promise novel approach Further trials warranted translate findings effective treatments.

Language: Английский

Citations

0
Engineering exosomes for mRNA delivery: a review DOI
Ting Yao,

X Dong,

Xinyu Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 144662 - 144662

Published: May 1, 2025

Language: Английский

Citations

0