Deoxyvasicinone hybrids in the management of Alzheimer's disease: Recent advances on manmade derivatives, pharmacological activities, and structure–activity relationship DOI Open Access

A Gaur,

Yash Pal Singh, Rajiv Sharma

et al.

Archiv der Pharmazie, Journal Year: 2024, Volume and Issue: 358(1)

Published: Dec. 27, 2024

Alzheimer's disease (AD) is a prevalent neurological illness that affects over 80% of aged adults globally in cases dementia. Although the exact pathophysiological causes AD remain unclear, its pathogenesis primarily driven by several distinct biochemical alterations: (i) accumulation toxic Aβ plaques, (ii) hyperphosphorylation tau proteins, (iii) oxidative stress resulting cell death, and (iv) an imbalance between two main neurotransmitters, glutamate acetylcholine (ACh). Currently, there are very few medications available no treatment. Presently marketed include memantine, N-methyl-d-aspartate receptor (NMDA) antagonist, acetylcholinesterase (AChE) inhibitors: rivastigmine, donepezil, galantamine. Unfortunately, these only useful initial stages AD. The mentioned provide symptomatic relief do not slow down progression advanced stages. Therefore, urgent need to develop potential candidates treat AD, symptomatically therapeutically. Many research groups focus on natural products due their diverse therapeutic profiles easy availability. One such product deoxyvasicinone, isolated from Adhatoda vasica. Given broad pharmacological profile, various researchers have developed semisynthetic hybrids deoxyvasicinone address multifaceted diseases like In this review article, we tried summarize past decade (2014-2024) for managing We design, activity, structure-activity relationship (SAR) analysis. hope enhances reader's understanding future exploratory options management.

Language: Английский

Comprehensive Overview of Alzheimer’s Disease: Etiological Insights and Degradation Strategies DOI Open Access
Manish Kumar Singh,

Yoonhwa Shin,

Songhyun Ju

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 6901 - 6901

Published: June 24, 2024

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and affects millions of individuals globally. AD associated with cognitive decline memory loss that worsens aging. A statistical report using U.S. data on estimates approximately 6.9 million suffer from AD, a number projected to surge 13.8 by 2060. Thus, there critical imperative pinpoint address its hallmark tau protein aggregation early prevent manage debilitating effects. Amyloid-β proteins are primarily formation plaques neurofibril tangles in brain. Current research efforts focus degrading amyloid-β or inhibiting their synthesis, particularly targeting APP processing hyperphosphorylation, aiming develop effective clinical interventions. However, navigating this intricate landscape requires ongoing studies trials treatments truly make difference. Genome-wide association (GWASs) across various cohorts identified 40 loci over 300 genes AD. Despite wealth genetic data, much remains be understood about functions these role process, prompting continued investigation. By delving deeper into associations, novel targets such as kinases, proteases, cytokines, degradation pathways, offer new directions for drug discovery therapeutic intervention This review delves biological pathways disrupted identifies how variations within could serve potential treatment strategies. Through comprehensive understanding molecular underpinnings researchers aim pave way more therapies can alleviate burden devastating disease.

Language: Английский

Citations

10
Estrogen signalling and Alzheimer's disease: Decoding molecular mechanisms for therapeutic breakthrough DOI

Rishabh,

Manni Rohilla, Seema Bansal

et al.

European Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 60(1), P. 3466 - 3490

Published: May 10, 2024

Abstract In females, Alzheimer's disease (AD) incidences increases as compared to males due estrogen deficiency after menopause. Estrogen therapy is the mainstay for menopause and associated complications. Estrogen, a hormone with multifaceted physiological functions, has been implicated in AD pathophysiology. plays crucial role amyloid precursor protein (APP) processing overall neuronal health by regulating various factors such brain‐derived neurotrophic factor (BDNF), intracellular calcium signalling, death domain‐associated (Daxx) translocation, glutamatergic excitotoxicity, Voltage‐Dependent Anion Channel, Insulin‐Like Growth Factor 1 Receptor, estrogen‐metabolising enzymes apolipoprotein E (ApoE) polymorphisms. All these impact physiology of postmenopausal women. replacement therapies play an important treatment strategy prevent However, use may lead increased risks breast cancer, venous thromboembolism cardiovascular disease. Various therapeutic approaches have used mitigate effects on AD. These include therapy, Selective Receptor Modulators (SERMs), Beta (ERβ)‐Selective Agonists, Transdermal Delivery, Localised Combination Therapies, Metabolism Modulation Alternative Estrogenic Compounds like genistein from soy, notable phytoestrogen plant sources. mechanism via which modulate women not explained earlier thoroughly. Present review will enlighten all molecular mechanisms Along‐with this, association between estrogen, ApoE polymorphisms also be discussed

Language: Английский

Citations

6
Strategies for inhibiting amyloid fibrillation: Current status and future prospects DOI
Md Nadir Hassan, Murtaza Shabbir Hussain, Rizwan Hasan Khan

et al.

Progress in molecular biology and translational science, Journal Year: 2025, Volume and Issue: unknown, P. 145 - 168

Published: Jan. 1, 2025

Language: Английский

Citations

0
Potential Mechanism and Efficacy Evaluation of Transcranial Focused Ultrasound Therapy for Alzheimer's Disease DOI
Wei Qin,

Jiayi He,

Yi Zhou

et al.

Journal of Neuroscience Methods, Journal Year: 2025, Volume and Issue: unknown, P. 110428 - 110428

Published: March 1, 2025

Language: Английский

Citations

0
Introduction to Alzheimer's Disease, Biomarkers, and the AI Revolution DOI
Bancha Yingngam

Advances in medical technologies and clinical practice book series, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 23

Published: June 28, 2024

Alzheimer's disease (AD) is a progressive neurodegenerative that results in steady decline cognitive ability and memory function. As society ages, the need for an optimum AD management strategy becomes more important. This chapter analyzes stage-construction etiology escalating symptoms of discovered throughout this review, as well identification barrier to precise diagnosis. The artificial intelligence achieve quicker detection through machine learning, data analytics, predictive modeling also being considered. Therefore, employing AI AD-related studies novel approach enhancing patient outcomes. Proper diagnosis parallel increased probability many parameters one most difficult moments identify. However, use evaluation sensor network technologies big analysis has advanced, preventive instruments can be used. Thus, technology gives humanity hope stop or, at very least, slow down tragedy.

Language: Английский

Citations

1
The Neuroprotective Effect of Rooibos Herbal Tea Against Alzheimer's Disease: A Review DOI Creative Commons

Elias Chipofya,

Taskeen Docrat, Jeanine L. Marnewick

et al.

Molecular Nutrition & Food Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

ABSTRACT The world is experiencing a demographic shift toward an increasing proportion of elderly persons. Alzheimer's disease (AD) and other neurological disorders are far more likely to develop as people age. AD gradual, irreversible, degenerative brain disorder that progressively deteriorates memory cognitive function, eventually leading death. Treatment for the most significant unmet clinical need in neurology. There no effective treatment options prevent or reverse process. current medical management focuses primarily on temporarily easing symptoms, with little overall improvement. Although genetic predisposition lifestyle factors influence risk neurodegenerative disorders, recent research suggests dietary polyphenols solid antioxidant capacities play crucial roles determining health aging. Aspalathus linearis used produce Rooibos, popular South African herbal tea, which may modulate mechanisms such oxidative stress, tau protein, amyloid plaques, inflammation, metals, all have been associated AD. We reviewed literature evaluate potential neuroprotective effects Rooibos its major flavonoids understand underlying molecular mechanisms.

Language: Английский

Citations

1
Thin Polymeric Film Functionalized by AuNPs for High Sensitive Protein Biosensing DOI
Concetta Di Natale, Sara Coppola, Veronica Vespini

et al.

Published: June 3, 2024

Language: Английский

Citations

0
Deoxyvasicinone hybrids in the management of Alzheimer's disease: Recent advances on manmade derivatives, pharmacological activities, and structure–activity relationship DOI Open Access

A Gaur,

Yash Pal Singh, Rajiv Sharma

et al.

Archiv der Pharmazie, Journal Year: 2024, Volume and Issue: 358(1)

Published: Dec. 27, 2024

Alzheimer's disease (AD) is a prevalent neurological illness that affects over 80% of aged adults globally in cases dementia. Although the exact pathophysiological causes AD remain unclear, its pathogenesis primarily driven by several distinct biochemical alterations: (i) accumulation toxic Aβ plaques, (ii) hyperphosphorylation tau proteins, (iii) oxidative stress resulting cell death, and (iv) an imbalance between two main neurotransmitters, glutamate acetylcholine (ACh). Currently, there are very few medications available no treatment. Presently marketed include memantine, N-methyl-d-aspartate receptor (NMDA) antagonist, acetylcholinesterase (AChE) inhibitors: rivastigmine, donepezil, galantamine. Unfortunately, these only useful initial stages AD. The mentioned provide symptomatic relief do not slow down progression advanced stages. Therefore, urgent need to develop potential candidates treat AD, symptomatically therapeutically. Many research groups focus on natural products due their diverse therapeutic profiles easy availability. One such product deoxyvasicinone, isolated from Adhatoda vasica. Given broad pharmacological profile, various researchers have developed semisynthetic hybrids deoxyvasicinone address multifaceted diseases like In this review article, we tried summarize past decade (2014-2024) for managing We design, activity, structure-activity relationship (SAR) analysis. hope enhances reader's understanding future exploratory options management.

Language: Английский

Citations

0