Current Opinion in Neurology, Journal Year: 2025, Volume and Issue: unknown
Published: March 30, 2025
Purpose of review Cannabinoids have gained attention as a potential treatment for headache disorders, including migraine and cluster headache. While some studies suggest cannabinoids may provide analgesic anti-inflammatory effects, concerns remain regarding their overuse headache, cognitive impairment, psychological dependence. This study critically evaluates the current evidence on in treatment, weighing benefits risks. Recent findings With landscape expanding faster than ever, recent explore immune cells target cannabinoids. Immune express cannabinoid CGRP (calcitonin gene-related peptide) receptors. As result, might potentially modulate efficacy CGRP-targeting drugs. Additionally, emerging that enhance neuronal resilience mitigate central sensitization chronic migraine. Research into optimal delivery mechanisms, inhaled, sublingual, transdermal formulations, is also expanding. Summary are being studied particularly migraine, due to interaction with endocannabinoid system, which regulates pain, inflammation, vascular function. Studies help reduce frequency, alleviate improve sleep, though about dependency, medication retrospective indicate benefits, lack standardized dosing, long-term safety data, controlled trials limits conclusive recommendations. Comparisons conventional treatments show mixed results, presenting variable effectiveness risk adverse effects. Further research, randomized trials, needed establish safety, management.
Language: Английский