Nutrients,
Journal Year:
2025,
Volume and Issue:
17(5), P. 847 - 847
Published: Feb. 28, 2025
Background/Objectives:
The
skin,
being
the
body's
outermost
organ,
plays
a
vital
role
in
protecting
against
various
external
stimuli.
Ultraviolet
generates
reactive
oxygen
species
(ROS),
promoting
secretion
of
matrix
metalloproteinases
(MMPs)
and
inducing
collagen
degradation.
Many
studies
have
been
conducted
to
identify
natural
substances
that
can
prevent
or
delay
harmful
effects
UV.
Methods:
A
wound
healing
assay,
DCF-DA
(ROS)
JC-1
assay
were
performed
assess
bio-converted
eggplant
peels
(BEPs)
on
human
dermal
fibroblasts
(HDFs).
Western
blot
analysis
was
also
understand
underlying
mechanisms
for
their
effects.
Finally,
hematoxylin-eosin
staining
immunohistochemistry
animal
studies.
Results:
Our
study
evaluated
antioxidant
efficacy
BEPs
fermented
with
Lactobacillus
plantarum
hydrogen
peroxide
(H2O2)-HDFs
UVB-induced
skin
damage
hairless
mice.
We
demonstrated
exhibited
enhanced
properties
compared
non-fermented
(EPs).
facilitated
H2O2-damaged
HDFs,
reduced
ROS
levels,
restored
mitochondrial
membrane
potential.
suppressed
phosphorylation
ERK,
p38,
JNK
as
mechanism.
further
dietary
supplementation
downregulated
metalloproteinase
1
(MMP1)
expression
upregulated
I
(COL1)
UVB-damaged
mice,
indicating
more
effective
EPs.
Conclusions:
suggest
hold
significant
potential
protective
agent
mitigating
health.
