Green Medicine: Advancing Antimicrobial Solutions with Diverse Terrestrial and Marine Plant-Derived Compounds DOI Open Access
Du‐Min Jo, Nazia Tabassum,

Do Kyung Oh

et al.

Processes, Journal Year: 2024, Volume and Issue: 12(11), P. 2316 - 2316

Published: Oct. 22, 2024

Infectious diseases continue to cause global morbidity and mortality. The rise of drug-resistant pathogens is a major challenge modern medicine. Plant-based antimicrobials may solve this issue; hence, review discussed in detail plant-sourced antimicrobial drugs as an alternative toward bacterial, fungal, viral pathogens. Plant-derived chemicals from various sources such marine, medicinal, non-medicinal have diverse properties. Complex chemical profiles these allow molecules interact with several targets the microbial Due their multi-component composition, compounds are more effective less likely acquire resistance than single-target antibiotics. Medicinal herbs long been used for properties; however, plants also identified Other interesting new pathways identification include marine plants, which contain wide variety metabolites that both distinct varied. We conducted thorough literature search non-medicinal, plant-derived roles databases Scopus, PubMed, Google Scholar, Web Science. synergistic potential combining traditional attenuate pathogenesis. Based on existing research advancements, article emphasizes importance continuing into plant-based many integrating them therapies combat rising threat infections.

Language: Английский

Effectiveness of Herbal Medicines with Anti-Inflammatory, Antimicrobial, and Antioxidant Properties in Improving Oral Health and Treating Gingivitis and Periodontitis: A Systematic Review DOI Open Access
Giuseppina Malcangi, Angelo Michele Inchingolo, Lucia Casamassima

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 762 - 762

Published: Feb. 21, 2025

Objectives: This systematic review investigates the effectiveness of natural extracts with anti-inflammatory properties for improving oral health, particularly in managing gingivitis and periodontal disease (PD). With PD being a major global health issue, exacerbated by microbial dysbiosis oxidative stress, integration phytochemicals herbal formulations into therapy offers promising avenue adjunctive treatments. Methods: A was conducted following PRISMA guidelines registered under International Prospective Register Systematic Reviews (ID: 641944). Databases, including PubMed, Scopus, Web Science, were searched between 18–24 December 2024, using Boolean keywords combining terms such as “herbal medicine”, “plant extracts”, “anti-inflammatory”, “periodontal therapy”. Studies involving animal models, vitro data, or non-peer-reviewed articles excluded. Results: Seventeen studies met inclusion criteria. Polyherbal single-component (e.g., Camellia sinensis, Punica granatum, Zingiber officinale, Rosmarinus officinalis) demonstrated comparable efficacy to conventional agents like chlorhexidine (CHX). rinses, camellia sinensis gels, granatum reduced inflammation, improved gingival showed antimicrobial properties, offering effective alternatives. Conclusions: Natural products, single polyherbal formulations, provide safe alternatives PD. Their anti-inflammatory, antimicrobial, antioxidant support their role alongside scaling root planning (SRP) therapy. However, further large-scale, long-term are needed standardize establish optimal protocols.

Language: Английский

Citations

1
Mixture Containing 5% Polysaccharide Extract of Cerioporus squamosus (Huds.) Quélet, 5% Dexpanthenol, and 0.2% Hyaluronic Acid Shows In Vitro and In Vivo Wound Healing Properties DOI Creative Commons
Jovana Petrović, Tamara Carević, Jasmina Glamočlija

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 416 - 416

Published: March 15, 2025

Background: This study explores wound healing and the antimicrobial potential of a natural formulation containing polysaccharide extract from Cerioporus squamosus, hyaluronic acid, dexpanthenol. Methods: Wound effects were assessed using HaCaT keratinocytes, while activity was evaluated against human skin pathogens microdilution assay. In vitro cytotoxicity tests ensured safety, whereas in vivo further investigated an animal model. Gene expression analysis performed to assess molecular mechanisms involved. Results: The unique glucan composition C. squamosus (15.38% α-glucans 7.91% β-glucans) deviated typical mushroom profiles, warranting exploration its bioactivity. polysaccharides promoted 25.35% closure after 24 hours, three-component achieved 35.81% closure. Antibacterial showed minimum inhibitory concentration (MIC) 0.44–1.75 mg/mL bactericidal (MBCs) 0.88–3.50 mg/mL, antifungal ranged 0.22 0.44 (MICs) 0.88 (minimum fungicidal concentration—MFC). data that 60% treated wounds fully closed by day 11, despite no statistically significant difference control. However, gene highlighted VEGF collagen upregulation, indicating enhancement on level. Conclusions: novel demonstrated consistent properties, supporting as safe effective treatment for chronic acute wounds.

Language: Английский

Citations

1
Bioactive potential enhancement of Ginger (Zingiber officinale) through ball-mill assisted micronization DOI

S. Shiva,

Pradeep Anjana,

M.V. Navami

et al.

Food Chemistry Advances, Journal Year: 2025, Volume and Issue: 7, P. 100970 - 100970

Published: April 2, 2025

Language: Английский

Citations

0
The Influence of Basil and Cinnamon Essential Oils on Bioactive Sponge Composites of Collagen Reinforced with Hydroxyapatite DOI Open Access
Alina Robu, Mădălina Georgiana Albu Kaya, Aurora Antoniac

et al.

Materials, Journal Year: 2025, Volume and Issue: 18(3), P. 626 - 626

Published: Jan. 30, 2025

The increasing prevalence of acute traumas, surgical wounds, and chronic skin wounds poses significant therapeutic challenges for wound treatment. One the main concerns in care is danger infection, which a barrier to healing cause higher morbidity mortality rates. emergence drug-resistant bacterial species becoming more frequent every day. Antimicrobial dressings have become viable strategy hospital expense savings. Several factors, such as wound’s localization state, microbial load, cost, must be considered when choosing an appropriate antimicrobial dressing. key goals infection avoidance. This study addresses focusing on prevention combating strains. research explores development novel composite incorporating hydroxyapatite, known its osteoconductive properties, essential oils from basil cinnamon, recognized their activity. evaluates impact these additives properties surface morphology, water absorption, enzymatic degradation, mechanical performance. tests showed that two experimental samples (A1S A1BS) exhibited activity against Escherichia coli but not Staphylococcus aureus. results highlight dressings’ enhanced strength, controlled making them promising candidates advanced healing. Tailored applications were identified, with each dressing composition offering unique benefits specific wound-healing scenarios based balance between flexibility, structural support, bioactivity.

Language: Английский

Citations

0
Fractionation, HRLC-MS assisted phytochemical profiling, quantification, and evaluation of the chronic wound healing potential of ethanolic extract of Ardisia solanacea (Poir.) Roxb. DOI
Mohini Tawade, Jyotsna Chopade, Asha Thomas

et al.

Pharmacological Research - Natural Products, Journal Year: 2025, Volume and Issue: unknown, P. 100182 - 100182

Published: Feb. 1, 2025

Language: Английский

Citations

0
Optimized Sambucus nigra L., Epilobium hirsutum L., and Lythrum salicaria L. Extracts: Biological Effects Supporting Their Potential in Wound Care DOI Creative Commons
Diana Antonia Safta, Ana-Maria Vlase, Anca Pop

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 521 - 521

Published: April 27, 2025

This study aimed to optimize the extraction of phytocompounds intended for wound care applications from three plant species, Sambucus nigra L. flowers and Epilobium hirsutum Lythrum salicaria aerial parts, by using a Quality Design approach. The effects different methods (ultra-turrax ultrasonic-assisted extraction), ethanol concentrations (30%, 50%, 70%), times (3, 5, 10 min) were studied, during optimization step, polyphenol flavonoid contents maximized. phytochemical profiles optimized HEs (herbal extracts) assessed LC-MS/MS methods. antioxidant capacity was determined DPPH (2,2-diphenyl-1-picrylhydrazyl radical scavenging capacity) TEAC (Trolox equivalent capacity), FRAP (ferric reducing power) assays, while antibacterial activity evaluated against Escherichia coli, Pseudomonas aeruginosa, MSSA-methicillin-sensitive Staphylococcus aureus MRSA-methicillin-resistant aureus). Cell viability healing potential on keratinocytes fibroblasts. anti-inflammatory effect fibroblasts measuring levels interleukins IL-6 IL-8 production nitric oxide RAW 264.7 cells. major compounds rutin chlorogenic acid. HE showed strongest activity, demonstrated high cell viability. increased capacities. All extracts displayed effects, exhibited best in vitro wound-healing effect.

Language: Английский

Citations

0
Investigating the In Vitro Anti-Obesity Activity of the Ultrasonic-Assisted Extraction Process of Alkaloid- Rich Extract from <i>Mansoa alliacea</i> Flowers Using Response Surface Methodology DOI Creative Commons
Trần Chí Linh, Duy Toàn Phạm, Văn Mãi Đỗ

et al.

Natural Resources for Human Health, Journal Year: 2025, Volume and Issue: 5(3), P. 265 - 278

Published: May 26, 2025

<i>Mansoa alliacea</i> is a member of the Bignoniaceae family and common medicinal herb found in Asian nations. However, scientific studies conducted on this species are still limited. Therefore, study was to optimize extraction process <i>M. flowers evaluate therapeutic activity optimized alkaloid-rich extract. The optimization developed using response surface methodology with Box–Behnken model, assisted by ultrasound. optimal conditions were: temperature, 79°C; ultrasound time, 16 minutes; ethanol concentration, 80% (v/v); raw material–solvent ratio 1:30 (w/v). stated yielded total alkaloid content 196.58 mg atropine equivalent (AE)/g This prediction model determined be highly reliable. extract had excellent anti-obesity activity, IC<sub>50</sub> values observed various assays as follows: anti-cholesterol (IC<sub>50</sub>= 18.64 ± 0.32 µg/mL), pancreatic lipase inhibition 12.24 0.05 µg/ mL), carbohydrate metabolism enzymes including α-amylase (IC<sub>50</sub> = 13.49 0.23 µg/mL) α-glucosidase 68.56 1.99 µg/mL). Additionally, showed antioxidant IC₅₀ ranging from 11.87 µg/mL 30.43 2.13 µg/mL, depending assay used, exhibited antibacterial against Gram-negative bacterium <i>Enterobacter cloacae</i>, zone diameters 21.90 0.66 mm 46.60 0.53 mm. These bioactivities were related findings indicated that flower could used potential pharmaceutical product.

Language: Английский

Citations

0
Healing with herbs: an alliance with ‘nano’ for wound management DOI

Preksha Vinchhi,

Wong Tin Wui,

Mayur M. Patel

et al.

Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: 21(7), P. 1115 - 1141

Published: July 2, 2024

Introduction Wound healing is an intricate and continual process influenced by numerous factors that necessitate suitable environments to attain healing. The natural ability of wound often gets altered several external intrinsic factors, leading chronic occurrence. Numerous dressings have been developed, however, the currently available alternatives fail coalesce all conditions obligatory for rapid skin regeneration.

Language: Английский

Citations

2
Green Medicine: Advancing Antimicrobial Solutions with Diverse Terrestrial and Marine Plant-Derived Compounds DOI Open Access
Du‐Min Jo, Nazia Tabassum,

Do Kyung Oh

et al.

Processes, Journal Year: 2024, Volume and Issue: 12(11), P. 2316 - 2316

Published: Oct. 22, 2024

Infectious diseases continue to cause global morbidity and mortality. The rise of drug-resistant pathogens is a major challenge modern medicine. Plant-based antimicrobials may solve this issue; hence, review discussed in detail plant-sourced antimicrobial drugs as an alternative toward bacterial, fungal, viral pathogens. Plant-derived chemicals from various sources such marine, medicinal, non-medicinal have diverse properties. Complex chemical profiles these allow molecules interact with several targets the microbial Due their multi-component composition, compounds are more effective less likely acquire resistance than single-target antibiotics. Medicinal herbs long been used for properties; however, plants also identified Other interesting new pathways identification include marine plants, which contain wide variety metabolites that both distinct varied. We conducted thorough literature search non-medicinal, plant-derived roles databases Scopus, PubMed, Google Scholar, Web Science. synergistic potential combining traditional attenuate pathogenesis. Based on existing research advancements, article emphasizes importance continuing into plant-based many integrating them therapies combat rising threat infections.

Language: Английский

Citations

0