Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(6), P. 787 - 787
Published: May 24, 2025
When cells remain permanently trapped in a particular cell cycle stage, they are senescence. This also occurs the liver. Such often referred to as “zombie cells”, and an entire organ filled with these cells” is said be “zombie-like” state, characterized by lack of function. The senescence-associated secretory phenotype (SASP) encompasses substances release, which can significantly affect nearby tissues. While cellular senescence SASP related concepts, distinct. scoping review aims clarify role hepatocyte administration pharmaceuticals, well their relevance medico-legal practice, disability claims, insurance coverage. In this context, effects pharmaceuticals on senescent hepatocytes discussed, particularly regarding implications likely abused. conclusion, may relevant clinical or work because it sheds new light interpreting findings expert witness statements.
Language: Английский