Antiviral Plant Extracts: A Treasure for Treating Viral Diseases DOI Creative Commons
Gamil Sayed Gamil Zeedan,

Abeer M. Abdalhamed

Infectious diseases, Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 20, 2023

Viral infections remain a challenge in human and veterinary medicine due to factors such as viral mutations, new viruses, toxic effects, disease severity, intracellular viability, high costs, limited availability of antiviral drugs. Despite advancements immunization drugs, there is need for more effective compounds. Plants produce secondary metabolites that have shown activity, alkaloids, flavonoids, essential oils. Advanced analytical techniques like HPLC, GC-MS, NMR spectroscopy are used identify characterize these bioactive Flavonoids, terpenoids, lignans, sulphides, polyphenolics, coumarins, saponins among the groups compounds found plants demonstrated activity against viruses HIV, influenza, herpes simplex, hepatitis. Screening plant extracts isolating active allow scientists potential In vitro vivo studies significant their However, further research needed ensure safety, investigate drug interactions, explore combination therapies with other natural products. The use advanced helps target different stages life cycle. Examples specific mentioned, including SARS-CoV-2 various viruses. abstract emphasizes ongoing on sources, particularly plants, discovery compounds, while highlighting extensive therapies.

Language: Английский

Boosting the human antiviral response in conjunction with natural plant products DOI Creative Commons
Rashmi Srivastava, Neeraj Kumar Dubey,

Megha Sharma

et al.

Frontiers in Natural Products, Journal Year: 2025, Volume and Issue: 3

Published: Jan. 7, 2025

The increasing prevalence of viral infections and the emergence drug-resistant or mutant strains necessitate exploration novel antiviral strategies. Accumulating evidence suggests that natural plant products have significant potential to enhance human response. Various (PNPs) known for their properties been evaluated ability modulate immune responses inhibit infections. Research has focused on understanding mechanisms by which these PNPs interact with system complement existing therapies. control compounds such as alkaloids, flavonoids, terpenoids, polyphenols promote cytokine synthesis, increase T-cell macrophage activity, activate genes. Studies investigated molecular interactions between PNPs, viruses, host cells, exploring combining conventional drugs efficacy. However, several challenges remain, including identifying, characterizing, standardizing PNP extracts, optimizing dosages, improving bioavailability, assessing long-term safety, navigating regulatory approval. promising is being explored develop new, effective, This review outlines a framework an integrative approach connect full in combating health. By treatments, more effective sustainable management diseases can be achieved.

Language: Английский

Citations

4
Role of dietary supplements in the continuous battle against COVID‐19 DOI
Rahela Zaman, Vignesh Ravichandran, Chung Keat Tan

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(2), P. 1071 - 1088

Published: Jan. 2, 2024

Abstract A sudden outbreak of the COVID‐19 pandemic was a big blow to world community on every level. Created by novel coronavirus, SARS‐CoV‐2, which previously unknown human immune system. The expert opinion almost immediately united fact that most effective way fighting would be building immunity artificially via mass immunization program. However, it took about year for approval first vaccine against COVID‐19. In meantime, part general population started adapting nutritious diet plans and dietary supplements boost natural as potential prophylactic strategy SARS‐CoV‐2 infection. Whether they originate from mainstream medicine, such synthetic supplements, or traditional herbal remedies in form single poly‐herbs, these may comprise various components exhibit immunomodulatory, anti‐inflammatory, antioxidant, antimicrobial characteristics. There is substantial body predictions opinions suggesting enhancing one's with containing additional nutrients bioactive compounds like vitamins, minerals, amino acids, fatty phytochemicals, probiotics can enhance system's ability develop resistance COVID‐19, although none them have any conclusive evidence nor officially recommended World Health Organization (WHO). current review critically acclaims gap between public perception‐based preference real evidence‐based study weigh actual benefit relation prevention management.

Language: Английский

Citations

7
Exploring the potential mechanism of Andrographis paniculata compounds against neurodegenerative diseases based on network pharmacology and molecular docking DOI Creative Commons
Meili Yang, Hongbo Wei, Yuanzhen Xu

et al.

CHINESE JOURNAL OF ANALYTICAL CHEMISTRY (CHINESE VERSION), Journal Year: 2025, Volume and Issue: unknown, P. 100514 - 100514

Published: Feb. 1, 2025

Language: Английский

Citations

0
Neutrophils and COVID-19 DOI
Jasmin Šutković

Progress in molecular biology and translational science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Design, Synthesis, and Biological Evaluation of 5,8-Dimethyl Shikonin Oximes as SARS-CoV-2 Mpro Inhibitors DOI Creative Commons
Jiahua Cui, Shouyan Xiang,

Qijing Zhang

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(6), P. 1321 - 1321

Published: March 14, 2025

We have designed, synthesized, and characterized a small library of shikonin derivatives demonstrated their inhibitory activity against the main protease, Mpro, SARS-CoV-2. One analog, 5,8-dimethyl oxime (15), exhibited highest SARS-CoV-2 Mpro with an IC50 value 12.53 ± 3.59 μM. It much less toxicity as compared parent compound, shikonin, in both vitro vivo models. Structure–activity relationship analysis indicated that moieties on naphthalene ring functional groups attached to oxygen atom side chain play pivotal role enzymatic activity. Molecular docking results implied inhibitor 15 is perfectly settled core substrate-binding pocket by possibly interacting three catalytic residues, His41, Cys145, Met165. Overall, derivative deserves further investigation antiviral agent

Language: Английский

Citations

0
Post-marketing surveillance study on the effectiveness and safety of molnupiravir in high-risk COVID-19 outpatients: a prospective case series study DOI Creative Commons
Renato Ferreira‐da‐Silva, Lurdes Silva, Cristina Santos

et al.

Pharmacological Reports, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Language: Английский

Citations

0
DRONet: effectiveness-driven drug repositioning framework using network embedding and ranking learning DOI Open Access
Kuo Yang,

Yuxia Yang,

Shuyue Fan

et al.

Briefings in Bioinformatics, Journal Year: 2022, Volume and Issue: 24(1)

Published: Dec. 23, 2022

Abstract As one of the most vital methods in drug development, repositioning emphasizes further analysis and research approved drugs based on existing large amount clinical experimental data to identify new indications drugs. However, didn’t achieve enough prediction performance, these do not consider effectiveness information drugs, which make it difficult obtain reliable valuable results. In this study, we proposed a framework termed DRONet, full use comparative relationships (ECR) among as prior by combining network embedding ranking learning. We utilized learn deep features from heterogeneous drug-disease network, constructed high-quality drug-indication set including effectiveness-based contrast relationships. The ECR are combined effectively through designed learning model prioritize candidate Comprehensive experiments show that DRONet has higher accuracy (improving 87.4% Hit@1 37.9% mean reciprocal rank) than state art. case also demonstrates high reliability predicted results, potential guide development.

Language: Английский

Citations

15
New insight into the bioactivity of substituted benzimidazole derivatives: Repurposing from anti-HIV activity to cell migration inhibition targeting hnRNP M DOI

Mohamed O. Radwan,

Tsugumasa Toma,

Yuiichi Arakaki

et al.

Bioorganic & Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 86, P. 117294 - 117294

Published: April 26, 2023

Language: Английский

Citations

9
Beyond Psychotropic: Repurposing of Fluoxetine Toward Cancer Management and Its Molecular Mechanisms DOI Open Access
Sultan Kadasah, Abdulaziz M. Alqahtani,

Mohamed O. Radwan

et al.

Published: Feb. 12, 2024

Drug repurposing, rebranding an existing drug for a new therapeutic indication, is deemed beneficial approach quick and cost-effective discovery process by skipping preclinical, Phase 1 trials pharmacokinetic studies. Several psychotropic drugs including selective serotonin reuptake inhibitors (SSRIs) tricyclic antide-pressants (TCAs) were studied their potential application in different diseases es-pecially cancer therapy. Fluoxetine (FLX) one of the most prescribed agents from SSRIs class treatment several neuropsychiatric disorders with favourable safety profile. FLX exhibited oncolytic effects via mechanisms dis-tinct its main serotonergic activity. Taking advantage ability to rapidly pen-etrate blood-brain barrier, could be particularly useful brain tumors. This was proved vitro vivo experiments using as monotherapy or combination temozolomide (TMZ) radiotherapy. In this review literature, we summarize pleiotropic roles against cancers highlighting multifaceted activities interrupt prolif-eration molecular even surmount multidrug resistance (MDR). We elaborated on successful synergistic combinations such FXR/temozolomide FXR/raloxifene glioblastoma breast cancer, respectively. showcased pharmaceutical load car-riers enhance efficacy cells. first article ex-tensively summarizing all previous repurposing studies management cancer.

Language: Английский

Citations

3
Discovery of Quinacrine as a Potent Topo II and Hsp90 Dual-Target Inhibitor, Repurposing for Cancer Therapy DOI Creative Commons
Xin Pan,

Teng-yu Mao,

Yan-Wen Mai

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(17), P. 5561 - 5561

Published: Aug. 29, 2022

Topo II and Hsp90 are promising targets. In this study, we first verified the structural similarities between IIα ATPase Hsp90α N-ATPase. Subsequently, 720 compounds from Food Drug Administration (FDA) drug library kinase were screened using malachite green phosphate combination with II-mediated DNA relaxation MTT assays. antimalarial quinacrine was found to be a potential dual-target inhibitor of Hsp90. Mechanistic studies showed that could specifically bind domain inhibit activity without impacting cleavage. Furthermore, our study revealed N-ATPase activity. Significantly, has broad antiproliferation remains sensitive multidrug-resistant cell line MCF-7/ADR atypical drug-resistant tumor HL-60/MX2. Our identified as Hsp90, depending on ATP-binding domain, positioning it hit compound for further modification.

Language: Английский

Citations

12