Tropical Animal Health and Production, Journal Year: 2024, Volume and Issue: 56(8)
Published: Sept. 25, 2024
Language: Английский
Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12
Published: Jan. 14, 2025
Accelerating the genetic selection to obtain animals more resilient climate changes, and with a lower environmental impact, would greatly benefit by substantial shortening of generation interval. One way achieve this goal is generate male gametes directly from embryos. However, spermatogenesis complex biological process that, at present, can be partially reproduced in vitro only mouse. The development reliable 3D models able mimic architecture physiological microenvironment testis, represents possible strategy facilitate ex vivo haploid gamete domestic species. Here we describe creation bovine testicular bio-scaffolds their successful repopulation cells. In particular, testes are subjected three different decellularization protocols. Cellular compartment removal extracellular matrix preservation evaluated. generated then repopulated fibroblasts. results obtained demonstrate that protocol involving use 0.3% sodium dodecyl sulfate (SDS) for 12 h efficiently eliminates native cells, while preserving intact ECM composition microstructure. Its subsequent fibroblasts demonstrates cell homing, colonization growth, consistent scaffold ability sustain adherence proliferation. Overall, may constitute suitable artificial niche culture cells represent reproduce vitro.
Language: Английский
Citations
0
Biology, Journal Year: 2025, Volume and Issue: 14(1), P. 80 - 80
Published: Jan. 16, 2025
As global demand for sheep products increases, improving reproductive efficiency and lamb growth performance has become a priority farmers. Artificial insemination (AI) offers several advantages over natural mating, including improved genetic selection disease control. This study contributes to understanding the impact of different mating methods semen preservation techniques on traits in Palestinian Assaf under local breeding conditions. The research included 123 adult ewes from two farms, which were hormonally synchronized divided into three groups biotechnologies. Group 1 (G1) comprised 50 inseminated with frozen straws, while 2 (G2) had 37 fresh genetically superior rams. Both G1 G2 used 0.5 mL straws containing 250 million sperm, occurring 48 h post sponge removal eCG hormone injection. 3 (G3) consisted 36 that underwent at ratio ram 6 ewes. revealed significantly affected fertility rates (45.4, 61.1, 71.9% G1, G2, G3, respectively; p < 0.05). notably enhanced indicators (p 0.05), although it did not influence prolific lambing > Prolific impacted birth weight, weaning average daily gain 60 days across all but or final weight 180 management system weights Lamb sex influenced gains days, as well findings suggest that, artificial elite rams may reduce rates, improves rates. In conclusion, our demonstrates higher AI can be valuable tool sheep. These provide insights farmers region optimize strategies enhance production
Language: Английский
Citations
0
Animals, Journal Year: 2025, Volume and Issue: 15(2), P. 277 - 277
Published: Jan. 20, 2025
Genomic applications in beef cattle disease prevention have gained traction recent years, offering new strategies for improving herd health and reducing economic losses the livestock industry. Advances genomics, including identification of genetic markers linked to resistance, provide powerful tools early detection, selection, management resistant infectious diseases. By incorporating genomic technologies such as whole-genome sequencing, genotyping, transcriptomics, researchers can identify specific variants associated with resistance pathogens like bovine respiratory Johne’s disease. These insights allow more accurate breeding programs aimed at enhancing overall resilience. particular, enables individuals superior traits immune function, need antibiotic treatments animal welfare. Moreover, precision medicine, powered by data, supports development tailored strategies, targeted vaccination plans antimicrobial stewardship. Incorporation also offers potential facilitating proactive interventions that reduce spread infections. Despite challenges cost, data interpretation integration into current systems, advantages are substantial. As these advance, they anticipated crucial roles sustainability (by performance), profitability longevity), biosecurity decreasing likelihood outbreaks) production systems worldwide.
Language: Английский
Citations
0
Frontiers in Genetics, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 13, 2025
Breeding for efficient animals has been a major focus producers, aiming not only to increase profitability but also address the societal demands sustainability. Advances in next-generation sequencing over last decades have revolutionized our understanding of regulatory mechanisms related animal health and production. These advances, coupled with new analytical methods, bridged genome-to-phenome gap, yielding positive impacts on selective breeding (Clark et al., 2020). Furthermore, genome editing through CRISPR-cas9 system paradigm shift, offering opportunities introduce genetic variants potential maximize production (Banerjee Diniz, 2024; Mueller Van Eenennaam, 2022). In current Research Topic (RT), we collected reviews, case reports, original research articles from experts, highlighting progress high-throughput technologies their applications livestock science. Our objective is provide an overview recent genomic enhance gene regulation, epigenetics, architecture, its crosstalk phenotypic variation underlying production, nutrition, reproduction, health, environmental adaptation. This RT includes five scientific spanning topics epigenome, including nutrigenomics metabolomics various species. The article by Chen colleagues provided comprehensive technologies, study structural (SV). They discussed SV formation presented evolution methods detect variants. Moreover, they reviewed studies across multiple species (cattle, buffalo, equine, sheep, goats) elucidate basis differences traits adaptive linked SVs. authors highlighted significance SVs as source diversity among individuals. However, pointed out need further development cost-effective long-read improved algorithms designed manage complexity regions. Taking advantage public data whole-genome resequencing, Liu al. investigated architecture Xiangdong black goat compared six other breeds (Jintang, Jining, Guizhou, Du'an, Chengdu, Longlin) China. analyzed population structure, diversity, signatures. Among findings, reported moderate level goats, minimal inbreeding, substantial effective size. sweep analysis identified candidate genes involved immunity, growth development.Two focused functional genomics, uncovering pigs. explored dynamics divergence pigs analyzing cis-regulatory elements (CREs). chromatin accessibility profiles skeletal muscle, liver, fat tissues between Chinese (Meishan Enshi Black) Western (Duroc Large White) pig populations. whether changes were liver expression. Their findings liver-specific elements, increased correlating higher expression levels nearby genes. Another Fanalli examined dietary modulation understand Using RNA-Seq co-expression network analyses, impact diets containing 3% soybean oil (SOY3.0) versus standard 1.5% diet (SOY1.5) blood serum parameters 98-day-old distinct modules: co-expressed SOY3.0 treatment associated neurodegeneration, Alzheimer's disease, metabolic processes pathways, while SOY1.5 modulated pathways cholesterol metabolism type I diabetes mellitus. results highlight develop strategies optimizing health. this illustrates translational relevance human insights into how tailored fatty acid could lipid reduce disease risks, cardiovascular neurodegenerative disorders.Finally, advancing companion animals, Katz pioneering application therapy treating pulmonary hypertension (PH) dogs. prevalence pathophysiology PH, demonstrated that synthetic adeno-associated virus-mediated delivery ceramidase significantly drug improve spontaneously occurring PH dogs.Collectively, contributions within showcase transformative elucidating regulation. foundation future bridge gaps complex traits, sustainability efficiency systems.
Language: Английский
Citations
0
Revista Bio Ciencias, Journal Year: 2025, Volume and Issue: unknown
Published: March 4, 2025
La estimación de parámetros genéticos es esencial para garantizar el éxito los programas mejoramiento, ya que permite desarrollar criterios selección adecuados y predecir respuestas correlacionadas. El objetivo del estudio fue estimar la heredabilidad correlaciones genéticas duración gestación (DG), intervalo entre partos (IEP), días a primer servicio posparto (DPS), edad (EPS), abiertos (DA) servicios por concepción (NSC) en ganado multirracial condiciones tropicales. Los datos se analizaron con modelos univariados bivariados programa MTDFREML, obtener componentes covarianza. Las heredabilidades estimadas mediante fueron 0.00, 0.02, 0.03, 0.10, 0.25, 0.29, EPS, DA, NSC, IEP, DPS DG, respectivamente. obtenidas 0.12, 0.27, 0.08, 0.26, 0.30 0.46, DPS, 1.00, 0.90, 0.97, 0.79, 0.70, 0.99, -1.00, -0.59, -0.47, -0.36, -0.40, -0.15, -0.06 -0.05 IEP-DA, IEP-EPS, DPS-IEP, DPS-DA, DPS-EPS, DG-EPS, DA-EPS, NSC-EPS, DG-IEP, DPS-NSC, DG-NSC, IEP-NSC, DG-DA, SPD-DG NSC-DA, e IEP representa una oportunidad mejorarlas través un selección, mientras que, DA NSC valores cercanos cero. las características reproductivas hacen factible planteamiento mejoramiento genético puedan tomar cuenta diferentes estudiadas manera simultánea.
Citations
0
Tropical Animal Health and Production, Journal Year: 2025, Volume and Issue: 57(2)
Published: March 1, 2025
Language: Английский
Citations
0
Frontiers in Animal Science, Journal Year: 2025, Volume and Issue: 6
Published: March 13, 2025
Objective Embryo death in the early stages, primarily caused by lethal alleles homozygous state, is one of important challenges dairy cattle breeding. The availability large-scale genomic SNP data has proven to be a promising tool for identifying recessive genetic defects. This study was conducted identify and genes causing embryo Holstein using omics transcriptomic level. Methods High-density Bovine770K array genotypes 3117 samples whole-genome sequences (WGS) 743 cows were utilized SNPs, defined as those markers significantly departing from Hardy–Weinberg equilibrium lacking genotypes. Results potential candidate SNPs are harbored PARD3 , BAHD1 FZD3 ERGIC2 IQCN PROK1 PCTP, SH3GLB1 RASSF5 genes, according ARS-UCD1.2 Bos taurus genome assembly. Transcriptome analysis showed that these steadily expressed various embryonic tissues during different stages development, therefore considered genes. These play roles biological processes development prenatal survival ability embryos. contribute lethality-related mechanisms, including regulation cell polarity, placental phospholipid transport, apoptosis. Conclusion findings this provide insight into complex molecular mechanisms mortality at stage pregnancy following inheritance model.
Language: Английский
Citations
0
Journal of Dairy Science, Journal Year: 2023, Volume and Issue: 107(2), P. 643 - 648
Published: Sept. 29, 2023
We are faced with increasingly complex problems in animal production, such as the management of genetic diversity cattle populations, and there no easy solutions to these challenges. There is a fundamental conflict our selection programs because demand for elite genetics drives ongoing loss diversity. Managing this challenge will require participation many stakeholders system, each which has different incentives. Achieving necessary buy-in solid, objective evidence an actual problem tangible solutions.
Language: Английский
Citations
10
Animal Biotechnology, Journal Year: 2024, Volume and Issue: 35(1)
Published: Aug. 12, 2024
The flavour, tenderness and juiciness of the beef are all impacted by composition intramuscular fat (IMF), which is a key determinant quality. Thus, enhancing IMF cattle has become major area research. Consequently, aim this paper was to provide insight synthesis into emerging technologies, nutritional practices management strategies improve in cattle. This review examined current knowledge techniques approaches relevant farming industry. It includes thorough investigation animal handling, weaning age, castration, breed selection, sex determination, environmental factors, grazing methods, slaughter weight age. Additionally, it rigorously explored dietary energy levels optimization fatty acid profiles, as well use feed additives hormone implant with their associated regulations. also delved technologies that shaping future production, such genomic selection genome editing techniques, epigenomic analyses, microbiome manipulation strategies, transcriptomic profiling metabolomics analyses. In conclusion, holistic approach combining genomic, imperative for achieving targeted content ensuring high-quality production.
Language: Английский
Citations
3
Animals, Journal Year: 2023, Volume and Issue: 13(20), P. 3284 - 3284
Published: Oct. 21, 2023
Female fertility is the foundation of cow–calf industry, impacting both efficiency and profitability. Reproductive failure primary reason why beef cows are sold in U.S. cause an estimated annual gross loss USD 2.8 billion. In this review, we discuss status genomics, transcriptomics, systems genomics approaches currently applied to female tools available producers maximize genetic progress. We highlight opportunities limitations associated with using genomic transcriptomic discover genes regulatory mechanisms related fertility. Considering complex nature fertility, significant advances precision breeding will rely on holistic, multidisciplinary further advance our ability understand, predict, improve reproductive performance. While these technologies have advanced knowledge, next step translate research findings from bench on-farm applications.
Language: Английский
Citations
7