Flavonoids and their role in oxidative stress, inflammation, and human diseases DOI Creative Commons
Klaudia Jomová, Suliman Yousef Alomar,

Richard Valko

et al.

Chemico-Biological Interactions, Journal Year: 2025, Volume and Issue: unknown, P. 111489 - 111489

Published: March 1, 2025

Oxidative stress and chronic inflammation are important drivers in the pathogenesis progression of many diseases, such as cancers breast, kidney, lung, others, autoimmune diseases (rheumatoid arthritis), cardiovascular (hypertension, atherosclerosis, arrhythmia), neurodegenerative (Alzheimer's disease, Parkinson's Huntington's disease), mental disorders (depression, schizophrenia, bipolar disorder), gastrointestinal (inflammatory bowel colorectal cancer), other disorders. With increasing demand for less toxic more tolerable therapies, flavonoids have potential to effectively modulate responsiveness conventional therapy radiotherapy. Flavonoids polyphenolic compounds found fruits, vegetables, grains, plant-derived beverages. Six twelve structurally different flavonoid subgroups dietary significance include anthocyanidins (e.g. pelargonidin, cyanidin), flavan-3-ols epicatechin, epigallocatechin), flavonols quercetin, kaempferol), flavones luteolin, baicalein), flavanones hesperetin, naringenin), isoflavones (daidzein, genistein). The health benefits related their structural characteristics, number position hydroxyl groups presence C2=C3 double bonds, which predetermine ability chelate metal ions, terminate ROS radicals formed by Fenton reaction), interact with biological targets trigger a response. Based on these can exert both antioxidant or prooxidant properties, activity ROS-scavenging enzymes expression activation proinflammatory cytokines (e.g., interleukin-1beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α)), induce apoptosis autophagy, target key signaling pathways, nuclear factor erythroid 2-related 2 (Nrf2) Bcl-2 family proteins. This review aims briefly discuss mutually interconnected aspects oxidative inflammatory mechanisms, lipid peroxidation, protein oxidation, DNA damage, mechanism resolution inflammation. major part this article discusses role alleviating inflammation, two common components human diseases. results epidemiological studies also presented.

Language: Английский

Exploring Mimosamycin as a Janus Kinase 2 Inhibitor: A Combined Computational and Experimental Investigation DOI
Kamonpan Sanachai, Kowit Hengphasatporn, Supakarn Chamni

et al.

Computational Biology and Chemistry, Journal Year: 2025, Volume and Issue: 115, P. 108346 - 108346

Published: Jan. 7, 2025

Language: Английский

Citations

0
Zebrafish as a Vertebrate Model for High-Throughput Drug Toxicity Screening: Mechanisms, Novel Techniques, and Future Perspectives DOI Creative Commons
W. Wang,

Xuan Gao,

Lin Liu

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101195 - 101195

Published: Jan. 1, 2025

Language: Английский

Citations

0
Multi-omics architecture of childhood obesity and metabolic dysfunction uncovers biological pathways and prenatal determinants DOI Creative Commons
Nikos Stratakis, Augusto Anguita‐Ruiz, Lorenzo Fabbri

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 14, 2025

Childhood obesity poses a significant public health challenge, yet the molecular intricacies underlying its pathobiology remain elusive. Leveraging extensive multi-omics profiling (methylome, miRNome, transcriptome, proteins and metabolites) rich phenotypic characterization across two parts of Europe within population-based Human Early Life Exposome project, we unravel landscape childhood associated metabolic dysfunction. Our integrative analysis uncovers three clusters children defined by specific profiles, one which characterized not only higher adiposity but also high degree complications. This high-risk cluster exhibits complex interplay many biological pathways, predominantly underscored inflammation-related cascades. Further, incorporating comprehensive information from environmental risk-scape critical pregnancy period, identify pre-pregnancy body mass index pollutants like perfluorooctanoate mercury as important determinants cluster. Overall, our work helps to potential risk factors for prevention intervention strategies early in life course aimed at mitigating long-term consequences. Obesity encompasses numerous interconnected pathological mechanisms. Here, authors show that integrating data distinct profiles prenatal linked dysfunction, providing insights strategies.

Language: Английский

Citations

0
Carnosol inhibits influenza A virus by disrupting the viral envelope and interfering with Jak2/STAT3 signaling pathway DOI

Lishan Sun,

Yang Zhang,

Can Xu

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177606 - 177606

Published: April 1, 2025

Language: Английский

Citations

0
Natural biomimetic nano-system for drug delivery in the treatment of rheumatoid arthritis: a literature review of the last 5 years DOI Creative Commons
Jingyuan Li, Wei Li,

Liping Zhuang

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: May 9, 2024

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized primarily by synovitis, leading to the destruction of articular cartilage and bone ultimately resulting in joint deformity, loss function, significant impact on patients’ quality life. Currently, combination anti-rheumatic drugs, hormonal biologics used mitigate progression. However, conventional drug therapy has limited bioavailability, long-term use often leads resistance toxic side effects. Therefore, exploring new therapeutic approaches for RA great clinical importance. Nanodrug delivery systems offer promising solutions overcome limitations drugs. Among them, liposomes, first nanodrug system be approved application still widely studied, demonstrate ability enhance efficacy with fewer adverse effects through passive or active targeting mechanisms. In this review, we provide review research progress mechanisms various natural biomimetic nano-delivery therapy. Additionally, predict development trends prospects these systems, offering directions precision treatment RA.

Language: Английский

Citations

4
Therapeutic Inhibition of the JAK-STAT pathway in the treatment of Inflammatory Bowel Disease. DOI

Zihan Chen,

Ping Jiang, Dan Su

et al.

Cytokine & Growth Factor Reviews, Journal Year: 2024, Volume and Issue: 79, P. 1 - 15

Published: Aug. 3, 2024

Language: Английский

Citations

4
Treatment-resistant depression: molecular mechanisms and management DOI Creative Commons
Mayanja Kajumba, Angelina Kakooza‐Mwesige, Noeline Nakasujja

et al.

Molecular Biomedicine, Journal Year: 2024, Volume and Issue: 5(1)

Published: Oct. 17, 2024

Due to the heterogeneous nature of depression, underlying etiological mechanisms greatly differ among individuals, and there are no known subtype-specific biomarkers serve as precise targets for therapeutic efficacy. The extensive research efforts over past decades have not yielded much success, currently used first-line conventional antidepressants still ineffective close 66% patients. Most clinicians use trial-and-error treatment approaches, which seem beneficial only a fraction patients, with some eventually developing resistance. Here, we review evidence from both preclinical clinical studies on pathogenesis depression antidepressant response. We also discuss efficacy pharmacological non-pharmacological well novel emerging therapies. reveals that in response, specific, but rather involve an interplay between various neurotransmitter systems, inflammatory mediators, stress, HPA axis dysregulation, genetics, other psycho-neurophysiological factors. None current hypotheses sufficiently accounts interactional involved its etiology could partly explain limited success discovering efficacious treatment. Effective management treatment-resistant (TRD) requires targeting several mechanisms, using and/or personalized modalities, could, example, include multi-target pharmacotherapies augmentation psychotherapy approaches. Future guided by interaction provide more insights into potential etiologies TRD, precision biomarker targets, modalities.

Language: Английский

Citations

4
Molecular Mechanisms Underlying Neuroinflammation Intervention with Medicinal Plants: A Critical and Narrative Review of the Current Literature DOI Creative Commons
Sandra Maria Barbalho, Beatriz Leme Boaro,

Jéssica da Silva Camarinha Oliveira

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(1), P. 133 - 133

Published: Jan. 20, 2025

Neuroinflammation is a key factor in the progression of neurodegenerative diseases, driven by dysregulation molecular pathways and activation brain’s immune system, resulting release pro-inflammatory oxidative molecules. This chronic inflammation exacerbated peripheral leukocyte infiltration into central nervous system. Medicinal plants, with their historical use traditional medicine, have emerged as promising candidates to mitigate neuroinflammation offer sustainable alternative for addressing conditions green healthcare framework. review evaluates effects medicinal plants on neuroinflammation, emphasizing mechanisms action, effective dosages, clinical implications, based systematic search databases such PubMed, SCOPUS, Web Science. The findings highlight that like Cleistocalyx nervosum var. paniala, Curcuma longa, Cannabis sativa, Dioscorea nipponica reduce cytokines (TNF-α, IL-6, IL-1β), inhibit enzymes (COX-2 iNOS), activate antioxidant pathways, particularly Nrf2. NF-κB primary pathway inhibited across studies. While anti-inflammatory potential these significant, variability dosages phytochemical compositions limits translation. Here, we are modulators underscoring therapeutic potential. Future research should focus animal models, standardized protocols, safety assessments, integrating advanced methodologies, genetic studies nanotechnology, enhance applicability disease management.

Language: Английский

Citations

0
Sarcoidosis: molecular mechanisms and therapeutic strategies DOI Creative Commons

Danfeng Xu,

X. Tao,

Yibin Fan

et al.

Molecular Biomedicine, Journal Year: 2025, Volume and Issue: 6(1)

Published: Feb. 5, 2025

Abstract Sarcoidosis, a multisystemic granulomatous disease with unknown etiology, is characterized by formation of noncaseating granulomas, which can affect all organs. Recent studies have made outstanding achievement in understanding the pathology, genetics, and immune dysregulation involved granuloma sarcoidosis. Antigen stimulation genetically predisposed individuals enhances phagocytic activity antigen-presenting cells, including macrophages dendritic cells. CD4 + T cells initiate dysregulated responses secrete significant quantities inflammatory cytokines, interleukin (IL)-2 interferon-gamma (IFN-γ), play crucial role modulating aggregation fusion to form granulomas. The current therapeutic strategies focus on blocking spread granulomas protect organ function alleviate symptoms. efficacy traditional treatments, such as glucocorticoids immunosuppressants, has been confirmed management Promising agents encompass inhibitors like those targeting tumor necrosis factor (TNF)-α, well signaling pathways, Janus kinase (JAK) inhibitors, exhibit favorable prospects for application. Although there progress identification biomarkers diagnosis, prognosis, severity sarcoidosis, specific sensitive yet be identified. This review outlines recent advancements molecular mechanisms

Language: Английский

Citations

0
Recent Issues in the Development and Application of Targeted Therapies with Respect to Individual Animal Variability DOI Creative Commons
Natalia Kurhaluk, Halyna Tkachenko

Animals, Journal Year: 2025, Volume and Issue: 15(3), P. 444 - 444

Published: Feb. 6, 2025

This literature review explores the impact of molecular, genetic, and environmental factors on efficacy targeted therapies in veterinary medicine. Relevant studies were identified through systematic searches PubMed, Web Science, Scopus, ScienceDirect using keywords such as “species-specific treatment strategies”, “signalling pathways”, “epigenetic paragenetic influences”, “targeted therapies”, “veterinary medicine”, “genetic variation”, “free radicals oxidative stress”. Inclusion criteria included focusing species-specific therapeutic responses, genetic influences, stress. To ensure that only most recent relevant evidence was included, peer-reviewed publications from last two decades considered. Each study selected for analysis critically appraised, with a particular emphasis methodological quality, experimental design, scientific contribution to understanding how biological influence outcomes. A special placed used comparative, cross-species approach assess variability responses potential adverse effects. The synthesises role epigenetic highlights importance understand By highlighting variation, stress, individual species differences, argues personalised approaches. emphasises an would improve care inform future research aimed at optimising therapies, ultimately leading better animal health efficacy. key is its need more protocols take into account profiles factors; it also calls greater integration studies.

Language: Английский

Citations

0