Oxidative stress, aging, and diseases

Clinical Interventions in Aging, Journal Year: 2018, Volume and Issue: Volume 13, P. 757 - 772

Published: April 1, 2018

Oxidative stress, aging and diseases Ilaria Liguori,1 Gennaro Russo,1 Francesco Curcio,1 Giulia Bulli,1 Luisa Aran,1 David Della-Morte,2,3 Gaetano Gargiulo,4 Gianluca Testa,1,5 Cacciatore,1,6 Domenico Bonaduce,1 Pasquale Abete1 1Department of Translational Medical Sciences, University Naples “Federico II”, Naples, Italy; 2Department Systems Medicine, Rome Tor Vergata, Rome, 3San Raffaele Roma Open University, 4Division Internal AOU San Giovanni di Dio e Ruggi Aragona, Salerno, 5Department Medicine Health Molise, Campobasso, 6Azienda Ospedaliera dei Colli, Monaldi Hospital, Heart Transplantation Unit, Italy Abstract: Reactive oxygen nitrogen species (RONS) are produced by several endogenous exogenous processes, their negative effects neutralized antioxidant defenses. stress occurs from the imbalance between RONS production these Aging is a process characterized progressive loss tissue organ function. The oxidative theory based on hypothesis that age-associated functional losses due to accumulation RONS-induced damages. At same time, involved in age-related conditions (ie, cardiovascular [CVDs], chronic obstructive pulmonary disease, kidney neurodegenerative diseases, cancer), including sarcopenia frailty. Different types biomarkers have been identified may provide important information about efficacy treatment, guiding selection most effective drugs/dose regimens for patients and, if particularly relevant pathophysiological point view, acting specific therapeutic target. Given role pathogenesis many clinical aging, therapy could positively affect natural history but further investigation needed evaluate real interventions. purpose this paper review literature complex topic ever increasing interest. Keywords: elderly, reactive species, antioxidants

Language: Английский

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Animal Models of Inflammation for Screening of Anti-inflammatory Drugs: Implications for the Discovery and Development of Phytopharmaceuticals

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(18), P. 4367 - 4367

Published: Sept. 5, 2019

Inflammation is one of the common events in majority acute as well chronic debilitating diseases and represent a chief cause morbidity today’s era modern lifestyle. If unchecked, inflammation leads to development rheumatoid arthritis, diabetes, cancer, Alzheimer’s disease, atherosclerosis along with pulmonary, autoimmune cardiovascular diseases. involves complex network many mediators, variety cells, execution multiple pathways. Current therapy for inflammatory limited steroidal non-steroidal anti-inflammatory agents. The use these drugs reported severe adverse effects like gastrointestinal, cardiovascular, renal abnormalities. There massive need explore new agents selective action lesser toxicity. Plants isolated phytoconstituents are promising interesting sources anti-inflammatories. However, drug from natural has been linked hurdles nature extracts, difficulties isolation pure phytoconstituents, yield compounds minute quantities that insufficient subsequent lead development. Although various in-vivo in-vitro models available, judicious selection appropriate animal vital step early phase Systematic evaluation can facilitate identification potential sources. present review describes techniques screening its advantages limitations, elaboration on biological targets biomarkers prediction drugs. systematic approach proposed through article rationalize novel at initial stage programs.

Language: Английский

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Targeting cardiovascular inflammation: next steps in clinical translation

European Heart Journal, Journal Year: 2020, Volume and Issue: 42(1), P. 113 - 131

Published: Feb. 3, 2020

Systemic vascular inflammation plays multiple maladaptive roles which contribute to the progression and destabilization of atherosclerotic cardiovascular disease (ASCVD). These include: (i) driving atheroprogression in clinically stable phase disease; (ii) inciting atheroma precipitating acute coronary syndromes (ACS); (iii) responding cardiomyocyte necrosis myocardial infarction (MI). Despite an evolving understanding these biologic processes, successful clinical translation into effective therapies has proven challenging. Realizing promise targeting prevention treatment ASCVD will likely require more individualized approaches, as degree differs among patients. A large body evidence accumulated supporting use high-sensitivity C-reactive protein (hsCRP) a measure inflammation. Appreciating mechanistic diversity ACS triggers kinetics hsCRP MI may resolve purported inconsistencies from prior observational studies. Future trial designs incorporating hold enable approaches. The aim this Clinical Review is summarize current how contributes progression, destabilization, adverse outcomes. We offer forward-looking perspective on what next steps therapeutic approaches-enabling right patients with therapy at time-on road care.

Language: Английский

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Monocyte‐to‐HDL‐cholesterol ratio as a prognostic marker in cardiovascular diseases

Journal of Cellular Physiology, Journal Year: 2018, Volume and Issue: 233(12), P. 9237 - 9246

Published: Aug. 4, 2018

Inflammation and lipid accumulation are two basic hallmarks of atherosclerosis as a chronic disease. not only is local response but can also be considered systemic process followed by an elevation inflammatory mediators. Monocytes major source proinflammatory species during atherogenesis. In atherosclerosis, modified low‐density lipoproteins (LDLs) removed macrophages; these recruited in the vessel wall, inducing release cytokines inflamed tissue. Hence, cholesterol ester‐loaded plaque generated. High‐density lipoprotein‐cholesterol (HDL‐C) exhibits antiatherosclerotic effects neutralizing pro‐oxidant monocytes via inhibiting migration macrophages LDL oxidation addition to efflux from cells. Furthermore, HDL plays role suppressing activation proliferation–differentiation monocyte progenitor Thus, reduction HDL‐C may participate cardiovascular diseases (CVD). Given that relationship between high number low levels has been reported disorders, this review focused on understanding whether monocyte‐to‐HDL ratio could convenient marker predict development progression, CV events, instead individual count or level.

Language: Английский

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Matrix Metalloproteinases as Biomarkers of Atherosclerotic Plaque Instability

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(11), P. 3946 - 3946

Published: May 31, 2020

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases responsible for tissue remodeling and degradation extracellular matrix (ECM) proteins. MMPs may modulate various cellular signaling pathways in atherosclerosis progression rupture atherosclerotic plaques. The effect polymorphisms the expression both plaque plasma was shown. They independent predictors instability stable coronary heart disease (CHD) patients. Increased levels patients with advanced cardiovascular (CAD) acute syndrome (ACS) associated future risk events. These data confirm that be biomarkers as they target potential drug therapies atherosclerosis. provide important prognostic information, traditional factors, turn out to useful improving stratification.

Language: Английский

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The JAK–STAT pathway: an emerging target for cardiovascular disease in rheumatoid arthritis and myeloproliferative neoplasms

European Heart Journal, Journal Year: 2021, Volume and Issue: 42(42), P. 4389 - 4400

Published: July 31, 2021

Inflammation contributes centrally to cardiovascular diseases, and anti-inflammatory treatments can reduce events. The JAK-STAT pathway is an emerging target in inflammation, mainly rheumatoid arthritis (RA) chronic myeloproliferative neoplasms (MPNs), disorders that heighten risk. aim of this study was review the international literature on relationship between dysregulation RA/MPNs risk potential effects inhibitors. sustains inflammatory thrombotic events autoimmune such as RA MPNs. Here, imbalance exists pro- cytokines [increased levels interleukin (IL)-6, IL-1-β, tumour necrosis factor-α, decreased IL-10] over-expression some prothrombotic proteins, protein kinase Cε, surface activated platelets. This also operates atherosclerotic disease. inhibitors may related deaths conditions, but these agents requires more studies, especially with regard safety, particularly for effects. merit consideration curb heightened patients MPNs, rigorous assessment benefits risks.

Language: Английский

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Recent Advances in Aptamers-Based Nanosystems for Diagnosis and Therapy of Cardiovascular Diseases: An Updated Review

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2427 - 2443

Published: Feb. 1, 2025

The increasing global prevalence of cardiovascular diseases highlights the urgent need for innovative diagnostic and therapeutic strategies. Aptamers, small single-stranded nucleic acid molecules with exceptional specificity affinity target biomolecules, have emerged as promising tools precise diagnostics targeted therapies. Their selective binding capabilities provide valuable insights into molecular mechanisms underlying conditions. When integrated nanosystems, aptamers enhance delivery, bioavailability, stability agents, addressing challenges solubility degradation. This integration enables more drug advanced imaging techniques, improved interventions, ultimately improving management diseases. Recent advancements in aptamer selection methodologies, coupled their unique three-dimensional structures, significantly expanded application potential health. By combining novel approaches to disease diagnosis treatment are emerging, enhanced efficacy, safety, precision. review explores recent progress development aptamer-based nanosystems

Language: Английский

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Myocardial Infarction—From Atherosclerosis to Thrombosis

Arteriosclerosis Thrombosis and Vascular Biology, Journal Year: 2019, Volume and Issue: 39(8)

Published: July 24, 2019

Language: Английский

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Vulnerable Plaque, Characteristics, Detection, and Potential Therapies

Journal of Cardiovascular Development and Disease, Journal Year: 2019, Volume and Issue: 6(3), P. 26 - 26

Published: July 27, 2019

Plaque development and rupture are hallmarks of atherosclerotic vascular disease. Despite current therapeutic developments, there is an unmet necessity in the prevention It remains a challenge to determine at early stage if plaque will become unstable vulnerable. The arrival molecular imaging receiving more attention, considering it allows for better understanding biology human vulnerabilities. Various therapies with common goals have been tested high-risk patients cardiovascular In this work, process instability, along technologies sensing predicting plaques, debated. Updates on potential novel approaches also summarized.

Language: Английский

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The clinical efficacy of curcumin-containing nutraceuticals: An overview of systematic reviews

Pharmacological Research, Journal Year: 2018, Volume and Issue: 134, P. 79 - 91

Published: June 8, 2018

Language: Английский

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