Involvement of mitochondrial dynamics and mitophagy in diabetic endothelial dysfunction and cardiac microvascular injury

Archives of Toxicology, Journal Year: 2023, Volume and Issue: 97(12), P. 3023 - 3035

Published: Sept. 14, 2023

Language: Английский

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Frontiers in subclinical atherosclerosis and the latest in early life preventive cardiology

Singapore Medical Journal, Journal Year: 2025, Volume and Issue: 66(3), P. 141 - 146

Published: March 1, 2025

Subclinical atherosclerosis underlies most cardiovascular diseases, manifesting before clinical symptoms and representing a key focus for early prevention strategies. Recent advancements highlight the importance of detection management subclinical atherosclerosis. This review underscores that traditional risk factor levels considered safe, such as low-density lipoprotein cholesterol (LDL-C) glycated haemoglobin (HbA1c), may still permit development atherosclerosis, suggesting need stricter thresholds. Early-life interventions are crucial, leveraging brain's neuroplasticity to establish lifelong healthy habits. Preventive strategies should include more aggressive LDL-C HbA1c from youth persist into old age, supported by public health policies promote environments. Emphasising education on can fundamentally shift trajectory disease optimise long-term outcomes.

Language: Английский

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Dual-specificity phosphatase 1 interacts with prohibitin 2 to improve mitochondrial quality control against type-3 cardiorenal syndrome

International Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 21(3), P. 547 - 561

Published: Jan. 1, 2024

Type-3 cardiorenal syndrome (CRS-3) is acute kidney injury followed by cardiac injury/dysfunction. Mitochondrial may impair myocardial function during CRS-3. Since dual-specificity phosphatase 1 (DUSP1) and prohibitin 2 (PHB2) both promote mitochondrial quality control, we assessed whether these proteins were dysregulated CRS-3-related depression. We found that DUSP1 was downregulated in heart tissues from a mouse model of transgenic (DUSP1

Language: Английский

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Pyruvate kinase M2 sustains cardiac mitochondrial quality surveillance in septic cardiomyopathy by regulating prohibitin 2 abundance via S91 phosphorylation

Cellular and Molecular Life Sciences, Journal Year: 2024, Volume and Issue: 81(1)

Published: June 10, 2024

Language: Английский

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A Look at Primary and Secondary Prevention in the Elderly: The Two Sides of the Same Coin

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(15), P. 4350 - 4350

Published: July 25, 2024

The global population is experiencing an aging trend; however, this increased longevity not necessarily accompanied by improved health in older age. A significant consequence of demographic shift the rising prevalence multiple chronic illnesses, posing challenges to healthcare systems worldwide. Aging a major risk factor for multimorbidity, which marks progressive decline resilience and dysregulation multisystem homeostasis. Cardiovascular factors, along with comorbidities, play critical role development heart disease. Among age itself stands out as one most factors cardiovascular disease, its incidence notably increasing elderly population. However, individuals, especially those who are frail have under-represented primary secondary prevention trials aimed at addressing traditional such hypercholesterolemia, diabetes mellitus, hypertension. There concerns regarding optimal intensity treatment, taking into account tolerability drug interactions. Additionally, uncertainty persists therapeutic targets across different groups. This article provides overview relationship between highlighting various issues

Language: Английский

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Pgam5-mediated PHB2 dephosphorylation contributes to endotoxemia-induced myocardial dysfunction by inhibiting mitophagy and the mitochondrial unfolded protein response

International Journal of Biological Sciences, Journal Year: 2023, Volume and Issue: 19(14), P. 4657 - 4671

Published: Jan. 1, 2023

Numerous mitochondrial abnormalities are reported to result from excessive inflammation during endotoxemia.Prohibitin 2 (PHB2) and phosphoglycerate mutase 5 (Pgam5) have been associated with altered homeostasis in several cardiovascular diseases; however, their role endotoxemia-related myocardial dysfunction has not explored.Our experiments were aimed evaluate the potential contribution of Pgam5 PHB2 endotoxemia-induced cardiomyocytes, a focus on two endogenous protective programs that sustain integrity, namely mitophagy unfolded protein response (UPR mt ).We found transgenic mice resistant endotoxemia-mediated depression damage.Our assays indicated overexpression activates UPR , which maintains metabolism, prevents oxidative stress injury, enhances cardiomyocyte viability.Molecular analyses further showed binds dephosphorylates PHB2, resulting cytosolic translocation PHB2.Silencing or transfection phosphorylated mutant mouse HL-1 cardiomyocytes prevented loss mitochondrially-localized activated presence LPS.Notably, cardiomyocyte-specific deletion vivo attenuated LPS-mediated preserved viability.These findings suggest Pgam5/PHB2 signaling mitophagy/UPR targets for treatment cardiac dysfunction.

Language: Английский

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Screening of an FDA-approved compound library identifies apigenin for the treatment of myocardial injury

International Journal of Biological Sciences, Journal Year: 2023, Volume and Issue: 19(16), P. 5233 - 5244

Published: Jan. 1, 2023

Apigenin is the active ingredient in Ludangshen.Although previous studies reported cardioprotective actions of apigenin against doxorubicin (Dox)-induced cardiomyopathy, underlying mechanisms remain incompletely understood.Since beneficially regulates various aspects mitochondrial function and dynamics, we asked whether improves heart mice with Dox-induced cardiomyopathy by regulating unfolded protein response (UPR mt ).Co-administration significantly restored function, reduced myocardial swelling, inhibited cardiac inflammation, increased transcription UPR -related genes, promoted cardiomyocyte survival Dox-treated mice.In turn, blockade abolished mito-and cytoprotective effects apigenin, evidenced decreased ATP production, suppressed antioxidant capacity, apoptosis, Dox-treated, cultured HL-1 cardiomyocytes.Furthermore, treatment prevented downregulation Sirt1 Atf5 expression, beneficial were completely nullified knockout (KO) or after siRNA-mediated knockdown vitro.We thus provide novel evidence for a promotive effect on via regulation Sirt1/Atf5 pathway.Our findings uncover that seems to be an effective therapeutic agent alleviate Dox-mediated cardiotoxicity.

Language: Английский

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The Role of Cardiovascular Rehabilitation in the Elderly Patient

Cardiology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 10

Published: June 12, 2024

<b><i>Background:</i></b> Cardiovascular disease is the leading cause of morbidity and mortality in elderly population. Coronary artery disease, heart failure, peripheral constitute prevailing conditions. Cardiac rehabilitation (CR) represents a cornerstone secondary prevention cardiovascular since it has been associated with significant benefits above-mentioned conditions, by significantly reducing outcomes improving functional independence quality life. Besides, CR offers background for optimizing control risk factors implementing physical exercise, also providing psychological social support. <b><i>Summary:</i></b> The prevalence increases age, associating high mortality. In addition, comorbidities, frailty, other geriatric entities that entail poor prognosis, are often present patients. Indeed, frailty recommended to be systematically addressed patients there growing evidence regarding programs this setting, lower adverse events during follow-up. However, less referred after event when compared their younger counterparts. review, we summarized population established proposing comprehensive framework integrates personalized care strategies. <b><i>Key Messages:</i></b> morbimortality, especially elderly. management poses unique challenges, they represent heterogeneous group low. can provide older patients, encompassing training specific syndromes.

Language: Английский

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Prevalence of metabolic syndrome in patients with inflammatory bowel disease: a meta-analysis on a global scale

Journal of Health Population and Nutrition, Journal Year: 2025, Volume and Issue: 44(1)

Published: April 9, 2025

Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that increase the risk cardiovascular diseases (CVD). Patients with inflammatory bowel disease (IBD) may be at higher developing MetS due to chronic inflammation, altered adipokine profiles, and effects corticosteroid treatment. However, prevalence in IBD patients remains inconsistent across studies. This meta-analysis aims estimate compare its occurrence between Crohn's (CD) ulcerative colitis (UC). A systematic search was conducted PubMed, Scopus, Embase, Web Science from their inception up January 19, 2025. Eligible observational studies reporting were included. Meta-analysis performed using random-effects model, heterogeneity assessed via I² statistic. Comprehensive Meta-Analysis (CMA) software, version 4.0 used for analysis. The pooled 21.8% (95% CI: 14.3-31.6%). UC (32.7%, 95% 16.0-55.5%) compared CD (14.1%, 8.6-22.3%). had significantly odds than those (OR = 1.38, 1.03-1.85, P 0.02). Additionally, older without (MD: 9.89, 5.12-14.67, < 0.01). In summary, this reveals notable among IBD, particularly UC, where CD. analysis also shows tend older, suggesting age as contributing factor. These findings underscore need routine screening care, especially elderly patients.

Language: Английский

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PKM2 interacts with and phosphorylates PHB2 to sustain mitochondrial quality control against septic cerebral-cardiac injury

International Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 21(4), P. 633 - 643

Published: Jan. 1, 2024

Sepsis induces profound disruptions in cellular homeostasis, particularly impacting mitochondrial function cardiovascular and cerebrovascular systems.This study elucidates the regulatory role of Pyruvate Kinase M2 (PKM2)-Prohibitin 2 (PHB2) axis quality control during septic challenges its protective effects against myocardial cerebral injuries.Employing LPS-induced mouse models, we demonstrate a significant downregulation PKM2 PHB2 both heart brain tissues post-sepsis, with corresponding impairments dynamics, including fission, fusion, mitophagy.Overexpression not only restores function, as evidenced by normalized ATP production membrane potential but also confers resistance to oxidative stress mitigating reactive oxygen species generation.These mechanisms translate into substantial vivo benefits, transgenic mice overexpressing or displaying remarkable sepsis-induced cardiomyocyte neuronal apoptosis, organ dysfunction.Our findings highlight PKM2-PHB2 interaction novel therapeutic target for sepsis, providing foundation future research mitochondrial-based interventions treat this condition.The study's insights molecular underpinnings failure pave way clinical applications management sepsis related pathologies.

Language: Английский

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