Delayed Effects of tDCS Combined with Cognitive Behavioral Therapy in Major Depression: A Randomized, Double-Blind Pilot Trial DOI Creative Commons
Sandra Carvalho, Catarina M. M. Coelho, Jorge Leite

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(5), P. 444 - 444

Published: April 25, 2025

Aims: This pilot study assessed the potential psychosocial and therapeutic impacts of augmenting transcranial direct current stimulation (tDCS) with cognitive behavioral therapy (CBT) in treatment-naïve patients diagnosed major depressive disorder (MDD). Methods: In this double-blind randomized controlled trial, 10 subjects were into two groups—CBT active tDCS (active tDCS; n = 6; M 33.3 years; 4 females) or CBT sham (Sham; 4; 31.2 2 females). Severity depression was measured Montgomery–Åsberg Depression Rating Scale (MADRS) Beck Inventory (BDI). Participants’ secondary outcomes included life satisfaction, sleep quality, anxiety symptoms. They at baseline, following treatment (week 6), 2, 4, 8, 12-week follow-ups. Results: By week 12, group’s BDI scores showed greater improvement relative to group. There also significant differences between groups over time MADRS scores. Sleep quality improved group, many participants achieving symptom-free status—defined as 9 less supported by consistently low scores—by end follow-up period. Conclusions: These preliminary data indicate that combination may optimize MDD through symptom relief sleep, while prolonging benefits treatment.

Language: Английский

Telomerase activity and telomere homeostasis in major depressive disorder, schizophrenia and bipolar disorder: a systematic review. DOI

Johanna Thurin,

Bruno Étain, Frank Bellivier

et al.

Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
The Inaccuracy of the Mood Disorder Questionnaire for Bipolar Disorder in a Community Sample: From the “DYMERS” Construct Toward a New Instrument for Detecting Vulnerable Conditions DOI Open Access

Elisa Cantone,

Antonio Urban, Giulia Cossu

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(9), P. 3017 - 3017

Published: April 27, 2025

Background/Objectives: The Mood Disorder Questionnaire (MDQ) is a widely used tool for the early detection of Bipolar (BD), yet its diagnostic accuracy remains debated. In particular, MDQ often yields false positives in individuals with anxiety, stress-related, or personality disorders, raising questions about clinical utility. This study aimed primarily to evaluate sensitivity, specificity, and predictive values identifying BD within large, community-based sample using structured interviews. Additionally, we explored construct DYMERS (Dysregulation Mood, Energy, Social Rhythms Syndrome), proposed condition characterized by mood instability, hyperactivation traits, rhythm dysregulation among MDQ-positive without formal psychiatric diagnosis. Methods: A total 4999 adults were surveyed across six Italian regions stratified random sampling method. Psychiatric diagnoses established DSM-IV-TR criteria via Advanced Neuropsychiatric Tools Assessment Schedule (ANTAS). was administered face validated version, positivity cut-off ≥7. exhibited low sensitivity high specificity (0.962; 95% CI: 0.961–0.963). Results: Among 2337 analyzable cases, showed (96.2%) but (42.9%) BD, indicating limited effectiveness as screening tool. terms, this implies that while are unlikely be positives, substantial proportion true cases not identified. Notably, significant subgroup displayed features consistent DYMERS. Conclusions: Our findings confirm value community samples. However, may help identify broader spectrum captured current systems. Future research should focus on validating entity developing targeted instruments capable capturing emerging dimension psychopathology.

Language: Английский

Citations

0
Investigating causal relationships between gene expression and major depressive disorder via brain bulk-tissue and cell type-specific eQTL: A Mendelian randomization and Bayesian colocalization study DOI
Chung‐Chih Liao, S. Y. Wu, Chun‐I Lee

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: 383, P. 167 - 178

Published: April 29, 2025

Language: Английский

Citations

0
Schaftoside Reduces Depression- and Anxiogenic-like Behaviors in Mice Depression Models DOI Creative Commons

Hu Yue,

Yaoxue Gan,

Lei Jia

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(3), P. 238 - 238

Published: Feb. 24, 2025

Background: Major depressive disorder is a common mental health issue characterized by persistently low mood and high morbidity mortality. The major pathophysiology neuroinflammation, as evidenced elevated cytokine levels. Patients often fail to achieve full remission with the use of currently available antidepressants, prompting search for new treatment options. Schaftoside (SS), flavonoid found in traditional Chinese herbs, has both antioxidant anti-inflammatory properties. However, its antidepressant effects are poorly understood. Methods: Male C57BL/6 mice underwent chronic unpredictable mild stress (CUMS) lipopolysaccharide (LPS) induce depression- anxiety-like behaviors. SS was administered at 40, 80, 160 mg/kg 28 days. effect on depression-like behaviors assessed using behavioral assays, ELISA used measure pro-inflammatory cytokines serum hippocampus. Results: significantly decreased immobility forced swim tail suspension tests, increased sucrose preference test, reduced feeding latency novelty-suppressed test. These findings indicate improved depression showed that lowered interleukin-1 beta (IL-1β), IL-6, tumor necrosis factor-alpha levels hippocampus CUMS mice. Conclusions: Our study indicates anxiolytic effects, possibly through neuroinflammatory processes, making it promising therapeutic candidate depression, thus deserves further investigation into mechanisms clinical efficacy.

Language: Английский

Citations

0
Delayed Effects of tDCS Combined with Cognitive Behavioral Therapy in Major Depression: A Randomized, Double-Blind Pilot Trial DOI Creative Commons
Sandra Carvalho, Catarina M. M. Coelho, Jorge Leite

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(5), P. 444 - 444

Published: April 25, 2025

Aims: This pilot study assessed the potential psychosocial and therapeutic impacts of augmenting transcranial direct current stimulation (tDCS) with cognitive behavioral therapy (CBT) in treatment-naïve patients diagnosed major depressive disorder (MDD). Methods: In this double-blind randomized controlled trial, 10 subjects were into two groups—CBT active tDCS (active tDCS; n = 6; M 33.3 years; 4 females) or CBT sham (Sham; 4; 31.2 2 females). Severity depression was measured Montgomery–Åsberg Depression Rating Scale (MADRS) Beck Inventory (BDI). Participants’ secondary outcomes included life satisfaction, sleep quality, anxiety symptoms. They at baseline, following treatment (week 6), 2, 4, 8, 12-week follow-ups. Results: By week 12, group’s BDI scores showed greater improvement relative to group. There also significant differences between groups over time MADRS scores. Sleep quality improved group, many participants achieving symptom-free status—defined as 9 less supported by consistently low scores—by end follow-up period. Conclusions: These preliminary data indicate that combination may optimize MDD through symptom relief sleep, while prolonging benefits treatment.

Language: Английский

Citations

0