Long-term cognitive and autonomic effects of COVID-19 in young adults: a cross-sectional study at 28 months

Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)

Published: Jan. 16, 2025

The COVID-19 pandemic, caused by SARS-CoV-2, has had profound global impacts since its emergence in late 2019. Whilst acute symptoms are well-documented, increasing evidence suggests long-term consequences extending beyond the phase. This study aimed to investigate cognitive and autonomic effects of young adults. We conducted a cross-sectional comparing adults with history (n = 34) matched controls 34). Cognitive function was assessed using Sternberg Task, Stroop Go/No-Go Task (GNG). Autonomic evaluated heart rate variability (HRV) parameters. average time interval between infection testing 28.2 months. group showed significantly increased reaction 2-item absent condition (p 0.044) errors 4-item present 0.012) neutral response 0.028) normalized for completing task 0.022) Task. No significant differences were found GNG HRV parameters did not differ groups, although trends toward higher overall observed group. Young who approximately 28 months ago show minimal impact on regulation. However, subtle inefficiencies persist, particularly working memory executive tasks. These findings suggest generally favorable prognosis following mild moderate but highlight need further investigation into persistent effects.

Language: Английский

Cognitive Function and Brain Structure in COVID-19 Survivors: The Role of Persistent Symptoms

Behavioural Brain Research, Journal Year: 2024, Volume and Issue: 476, P. 115283 - 115283

Published: Oct. 3, 2024

Persistent COVID-19 symptoms post-acute state have been shown to a significant negative impact on brain structure and function. In this study, we conducted magnetic resonance imaging (MRI) of the whole in 43 working-age adults (mean age: 44.79±10.80; range: 24-65 years) with history (731.17±312.41 days post-diagnosis), also assessed their cognitive function (processing speed, attention, working memory, executive function, recognition memory), mental health, sleep quality. MRI data were processed using FSL derive regional volumes for bilateral nucleus accumbens, caudate, pallidum, putamen, thalamus, amygdala, hippocampus, total grey matter, white cerebral spinal fluid volume, analysed relation persistent symptom load, Higher load was significantly associated smaller putamen lower response accuracy memory tasks, as well longer time complete task, poorer health Smaller fully mediated relationship between Further research is required confirm whether reduced volume its association poor persists survivors long term.

Language: Английский