The three-gene paraoxonase family: Physiologic roles, actions and regulation

Atherosclerosis, Journal Year: 2010, Volume and Issue: 214(1), P. 20 - 36

Published: Sept. 3, 2010

Language: Английский

---

Paraoxonases-1, -2 and -3: What are their functions?

Chemico-Biological Interactions, Journal Year: 2016, Volume and Issue: 259, P. 51 - 62

Published: May 27, 2016

Language: Английский

---

Redox signaling in cardiovascular health and disease

Free Radical Biology and Medicine, Journal Year: 2013, Volume and Issue: 61, P. 473 - 501

Published: April 16, 2013

Language: Английский

---

Atherothrombosis and Oxidative Stress: Mechanisms and Management in Elderly

Antioxidants and Redox Signaling, Journal Year: 2017, Volume and Issue: 27(14), P. 1083 - 1124

Published: Aug. 17, 2017

The incidence of cardiovascular events (CVEs) increases with age, representing the main cause death in an elderly population. Aging is associated overproduction reactive oxygen species (ROS), which may affect clotting and platelet activation, impair endothelial function, thus predisposing patients to thrombotic complications. Recent Advances: There increasing evidence suggest that aging imbalance between oxidative stress antioxidant status. Thus, upregulation ROS-producing enzymes such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase myeloperoxidase, along downregulation enzymes, superoxide dismutase glutathione peroxidase, occurs during aging. This predispose thrombosis by enhancing activation eliciting dysfunction. Recently, gut-derived products, trimethylamine N-oxide (TMAO) lipopolysaccharide, are emerging novel atherosclerotic risk factors, gut microbiota composition has been shown change aging, concur increased elderly.Antioxidant treatment ineffective at or disease. Further, anti-thrombotic seems work less population.Interventional trials antioxidants targeting implicated aging-related atherothrombosis warranted explore whether modulation redox status effective lowering CVEs elderly. Antioxid. Redox Signal. 27, 1083-1124.

Language: Английский

---

Human Paraoxonase-2 (PON2): Protein Functions and Modulation

Antioxidants, Journal Year: 2021, Volume and Issue: 10(2), P. 256 - 256

Published: Feb. 7, 2021

PON1, PON2, and PON3 belong to a family of lactone hydrolyzing enzymes endowed with various substrate specificities. Among PONs, PON2 shows the highest hydrolytic activity toward many acyl-homoserine lactones (acyl-HL) involved in bacterial quorum-sensing signaling. Accordingly, defense against pathogens, such as Brevundimonas aeruginosa (B. aeruginosa), was postulated be principal function PON2. However, recent findings have highlighted importance oxidative stress control, inhibition apoptosis, progression types malignancies. This review focuses on all these aspects

Language: Английский

---

Paraoxonase-2 (PON2) in brain and its potential role in neuroprotection

NeuroToxicology, Journal Year: 2013, Volume and Issue: 43, P. 3 - 9

Published: Sept. 4, 2013

Language: Английский

---

The role of paraoxonase in cancer

Seminars in Cancer Biology, Journal Year: 2017, Volume and Issue: 56, P. 72 - 86

Published: Nov. 22, 2017

Language: Английский

---

Oxidative stress and macrophage foam cell formation during diabetes mellitus‐induced atherogenesis: Role of insulin therapy

Pharmacology & Therapeutics, Journal Year: 2012, Volume and Issue: 136(2), P. 175 - 185

Published: Aug. 4, 2012

Language: Английский

---

The roles of PON1 and PON2 in cardiovascular disease and innate immunity

Current Opinion in Lipidology, Journal Year: 2009, Volume and Issue: 20(4), P. 288 - 292

Published: July 6, 2009

The paraoxonase (PON) gene family includes three members, PON1, PON2, and PON3. In-vitro mouse studies have demonstrated that all PONs are atheroprotective. Some, but not all, human epidemiologic observed associations between PON polymorphisms risk of cardiovascular disease (CVD). In this review, we summarize published within the last year, elucidating involvement PON1 PON2 in oxidative stress, CVD, innate immune responses.In a prospective study, 192QQ genotype low activity were associated with increased systemic stress for CVD. expression protected against Pseudomonas aeruginosa lethality Drosophila, suggesting can interfere quorum sensing vivo. attenuated macrophage triglyceride accumulation via inhibition diacylglycerol acyltransferase 1. Overexpression endoplasmic reticulum stress-induced apoptosis when was induced by interference protein modification Ca2+ deregulation.Both antioxidative atheroprotective effects PON1. mechanisms which exerts its emerging. Large-scale needed to further examine relationship genetic Elucidation physiologic substrates proteins is particular importance advance field.

Language: Английский

---

Pomegranate Protection against Cardiovascular Diseases

Evidence-based Complementary and Alternative Medicine, Journal Year: 2012, Volume and Issue: 2012, P. 1 - 20

Published: Jan. 1, 2012

The current paper summarizes the antioxidative and antiatherogenic effects of pomegranate polyphenols on serum lipoproteins arterial macrophages (two major components atherosclerotic lesion), using both in vitro vivo humans mice models. Pomegranate juice its by-products substantially reduced macrophage cholesterol oxidized lipids accumulation, foam cell formation (the hallmark early atherogenesis), leading to attenuation atherosclerosis development, consequent cardiovascular events.

Language: Английский

---