Glutamate Transport Proteins and Metabolic Enzymes are Poor Prognostic Factors in Invasive Lobular Carcinoma DOI Creative Commons
Todd Young, Shaymaa Bahnassy,

Theresa C. Abalum

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 29, 2024

Invasive Lobular Carcinoma (ILC) is a subtype of breast cancer characterized by distinct biological features, and limited glucose uptake coupled with increased reliance on amino acid lipid metabolism. Our prior studies highlight the importance glutamate as key regulator ILC tumor growth therapeutic response. Here we examine expression four proteins involved in transport metabolism - SLC3A2, SLC7A11, GPX4, GLUD1/2 racially diverse cohort 72 estrogen receptor-positive (ER+) 50 ER+ invasive ductal carcinoma, no special type (IDC/NST) patients primary disease. All are associated size ILC, but not IDC/NST, SLC3A2 also specifically linked to shorter overall survival presence comorbidities ILC. Notably, ER most strongly stage Black women from our TCGA. We further explore effects GLUD1 inhibition endocrine therapy-resistant cells using small-molecule inhibitor R162, which reduces protein levels, increases reactive oxygen species, inhibits oxidative phosphorylation. These findings potentially important role for particularly women, position several these glutamate-handling potential targets intervention

Language: Английский

Exploring the Deleterious Biologic Association of Stress With Cancer Disparities in Black Women DOI Creative Commons

Kevin P Collins,

Leisha C. Elmore

JAMA Network Open, Journal Year: 2025, Volume and Issue: 8(2), P. e2459763 - e2459763

Published: Feb. 14, 2025

Language: Английский

Citations

0
Four ways to help beat health inequities in the face of USAID cuts DOI Creative Commons
Lynn Hendricks, Raeka S. Aiyar,

Uma Palanisamy

et al.

Nature, Journal Year: 2025, Volume and Issue: 639(8053), P. 35 - 37

Published: March 3, 2025

Language: Английский

Citations

0
Glutamate Transport Proteins and Metabolic Enzymes are Poor Prognostic Factors in Invasive Lobular Carcinoma DOI Creative Commons
Todd Young, Shaymaa Bahnassy,

Theresa C. Abalum

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 29, 2024

Invasive Lobular Carcinoma (ILC) is a subtype of breast cancer characterized by distinct biological features, and limited glucose uptake coupled with increased reliance on amino acid lipid metabolism. Our prior studies highlight the importance glutamate as key regulator ILC tumor growth therapeutic response. Here we examine expression four proteins involved in transport metabolism - SLC3A2, SLC7A11, GPX4, GLUD1/2 racially diverse cohort 72 estrogen receptor-positive (ER+) 50 ER+ invasive ductal carcinoma, no special type (IDC/NST) patients primary disease. All are associated size ILC, but not IDC/NST, SLC3A2 also specifically linked to shorter overall survival presence comorbidities ILC. Notably, ER most strongly stage Black women from our TCGA. We further explore effects GLUD1 inhibition endocrine therapy-resistant cells using small-molecule inhibitor R162, which reduces protein levels, increases reactive oxygen species, inhibits oxidative phosphorylation. These findings potentially important role for particularly women, position several these glutamate-handling potential targets intervention

Language: Английский

Citations

0