Alzheimer’s disease and COVID-19: Interactions, intrinsic linkages, and the role of immunoinflammatory responses in this process DOI Creative Commons
Wei Li,

Lin Sun,

Ling Yue

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 9, 2023

Alzheimer’s disease (AD) and COVID-19 share many common risk factors, such as advanced age, complications, APOE genotype, etc. Epidemiological studies have also confirmed the internal relationship between two diseases. For example, found that AD patients are more likely to suffer from COVID-19, after infection with has a much higher of death than other chronic diseases, what’s interesting is developing in future significantly COVID-19. Therefore, this review gives detailed introduction perspectives epidemiology, susceptibility mortality. At same time, we focused on important role inflammation immune responses promoting onset

Language: Английский

Temperature-Responsive Multilayer Films Based on Block Copolymer-Coated Silica Nanoparticles for Long-Term Release of Favipiravir DOI
Li Xu,

Xingxing Zhang,

Zihan Chu

et al.

ACS Applied Nano Materials, Journal Year: 2021, Volume and Issue: 4(12), P. 14014 - 14025

Published: Dec. 9, 2021

Using surface-initiated atom-transfer radical polymerization, temperature-responsive block polymers were functionalized on the surface of silica nanocapsules (SNCs) by a "grafting-from" technique. Favipiravir, potential medicine candidate for treatment coronavirus disease (COVID-19), was encapsulated in polymer-coated SNCs and further incorporated into well-defined films layer-by-layer self-assembly. The multilayer composed poly(methacrylic acid) (PMAA) homopolymers exhibited swelling/deswelling behaviors under trigger temperature stimulus. For first time, impact steric hindrance assembling behavior, transition, delivering capacity nanocapsule-based investigated. with coronae higher resulted larger layering distance during film growth. Moreover, difference sustained release rates drug indicated their diverse diffusion coefficients intermolecular interactions within films, due to presence methyl spacer at amino group nanocapsule weaker ionic pairing between SNC PMAA homopolymers. profile from dependent value surrounding environment. At 37 40 °C, able efficiently entrap favipiravir, as low 50% released 80 days, whereas faster favipiravir triggered exposure lower 25 °C. This work demonstrates proof-of-concept platform SNC-incorporated multilayered internal structure on-demand vitro delivery.

Language: Английский

Citations

161
Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants DOI Creative Commons
S.E. Greasley, Stephen Noell, Olga Plotnikova

et al.

Journal of Biological Chemistry, Journal Year: 2022, Volume and Issue: 298(6), P. 101972 - 101972

Published: April 22, 2022

The COVID-19 pandemic continues to be a public health threat with emerging variants of SARS-CoV-2. Nirmatrelvir (PF-07321332) is reversible, covalent inhibitor targeting the main protease (Mpro) SARS-CoV-2 and active in PAXLOVID (nirmatrelvir tablets ritonavir tablets). However, efficacy nirmatrelvir underdetermined against evolving variants. Here, we evaluated vitro catalytic activity potency Mpro prevalent concern (VOCs) or interest (VOIs): Alpha (α, B.1.1.7), Beta (β, B.1.351), Delta (δ, B1.617.2), Gamma (γ, P.1), Lambda (λ, B.1.1.1.37/C37), Omicron (ο, B.1.1.529), as well original Washington wildtype strain. These VOCs/VOIs carry mutations at varying frequencies specifically for α, β, γ (K90R), λ (G15S), ο (P132H). In biochemical enzymatic assay characterization enzyme kinetics mutant Mpros demonstrates that they are catalytically comparable wildtype. We found has similar each including P132H observed variant Ki 0.635 nM compared 0.933 molecular basis these observations were provided by solution-phase structural dynamics determination bound ο, λ, β 1.63 2.09 Å resolution. data suggest potential maintain plasma concentrations many-fold times higher than amount required stop VOC/VOI, Omicron, from replicating cells.

Language: Английский

Citations

148
SARS-CoV-2 Mutations and Their Impact on Diagnostics, Therapeutics and Vaccines DOI Creative Commons

Suresh Thakur,

Shalitha Sasi,

Sindhu Gopinathan Pillai

et al.

Frontiers in Medicine, Journal Year: 2022, Volume and Issue: 9

Published: Feb. 22, 2022

With the high rate of COVID-19 infections worldwide, emergence SARS-CoV-2 variants was inevitable. Several mutations have been identified in genome, with spike protein as one mutational hot spots. Specific amino acid substitutions such D614G and N501Y were found to alter transmissibility virulence virus. The WHO has classified fitness-enhancing concern (VOC), interest (VOI) or under monitoring (VUM). VOCs pose an imminent threat they exhibit higher transmissibility, disease severity ability evade vaccine-induced natural immunity. Here we review landscape on structural non-structural proteins their impact diagnostics, therapeutics vaccines. We also look at effectiveness approved vaccines, antibody therapy convalescent plasma currently prevalent VOCs, which are B.1.17, B.1.351, P.1, B.1.617.2 B.1.1.529. further discuss possible factors influencing mutation rates future directions.

Language: Английский

Citations

139
A Global Picture: Therapeutic Perspectives for COVID-19 DOI
Vivek P. Chavda,

Carron Kapadia,

Shailvi Soni

et al.

Immunotherapy, Journal Year: 2022, Volume and Issue: 14(5), P. 351 - 371

Published: Feb. 21, 2022

The COVID-19 pandemic is a lethal virus outbreak by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which has severely affected human lives and the global economy. most vital part of research development therapeutic agents to design drug products manage efficiently. Numerous attempts have been in place determine optimal dose combination drugs treat disease on scale. This article documents information available SARS-CoV-2 its life cycle, will aid potential treatment options. A consolidated summary several natural repurposed depicted with current vaccine development. People high age, comorbity concomitant illnesses such as overweight, metabolic disorders, pulmonary disease, coronary heart renal failure, fatty liver neoplastic disorders are more prone create serious consequences. also presents an overview post-COVID-19 complications patients.

Language: Английский

Citations

74
Research on sleep status, body mass index, anxiety and depression of college students during the post-pandemic era in Wuhan, China DOI

Huiyan Duan,

Minmin Gong, Qiong Zhang

et al.

Journal of Affective Disorders, Journal Year: 2022, Volume and Issue: 301, P. 189 - 192

Published: Jan. 3, 2022

Language: Английский

Citations

70
Post-acute COVID-19 syndrome and kidney diseases: what do we know? DOI Open Access
Sidar Çöpür, Metehan Berkkan, Carlo Basile

et al.

Journal of Nephrology, Journal Year: 2022, Volume and Issue: 35(3), P. 795 - 805

Published: March 16, 2022

Language: Английский

Citations

70
Activatable Probes for Ratiometric Imaging of Endogenous Biomarkers In Vivo DOI
Qinrui Fu, Xiao Yang, Mengzhen Wang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(5), P. 3916 - 3968

Published: Jan. 23, 2024

Dynamic variations in the concentration and abnormal distribution of endogenous biomarkers are strongly associated with multiple physiological pathological states. Therefore, it is crucial to design imaging systems capable real-time detection dynamic changes for accurate diagnosis effective treatment diseases. Recently, ratiometric has emerged as a widely used technique sensing due its advantage circumventing limitations inherent conventional intensity-dependent signal readout methods while also providing built-in self-calibration correction. Here, recent progress probes their applications outlined. Ratiometric classified according mechanisms, photoacoustic imaging, optical including photoluminescence self-luminescence magnetic resonance dual-modal discussed. The such pH, reactive oxygen species (ROS), nitrogen (RNS), glutathione (GSH), gas molecules, enzymes, metal ions, hypoxia discussed detail. Additionally, this Review presents an overview challenges faced field along future research directions.

Language: Английский

Citations

31
The Impact of Age Difference on the Efficacy and Safety of COVID-19 Vaccines: A Systematic Review and Meta-Analysis DOI Creative Commons
Jiting Wang, Tong Yue, Duo Li

et al.

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: Dec. 6, 2021

Objective This meta-analysis compared the efficacy and safety of five kinds COVID-19 vaccines in different age groups (young adults older adults), aiming to analyze difference adverse events (AEs) rate virus geometric mean titer (GMT) values between young people, order find a specific trend, explore causes this trend through meta-analysis. Method Meta-analysis was used eligible articles. The modified Jadad scoring scale evaluate quality literature with system 1 7. primary endpoint effectiveness index GMT. endpoints were incidence local AEs systemic AEs. Stata 12.0 software for Revman 5.0 map risk publication bias, Egger’s test bias. Results GMT higher than (SMD = 1.40, 95% CI (0.79, 2.02), P<0.01). There people elderly (OR 1.10, (1.08, 1.12), P<0.01; OR 1.18, (1.14, 1.22), Conclusion immune effect after being vaccinated better that elderly, but worse old most common fever, rash, muscle pain, which tolerable people. As lower, they can also be safely; reason low level related Immunosenescence. vaccine tolerance ages needs studied continuously.

Language: Английский

Citations

68
Advances in the development of therapeutic strategies against COVID-19 and perspectives in the drug design for emerging SARS-CoV-2 variants DOI Creative Commons

Jialing Yin,

Chengcheng Li, Chunhong Ye

et al.

Computational and Structural Biotechnology Journal, Journal Year: 2022, Volume and Issue: 20, P. 824 - 837

Published: Jan. 1, 2022

Since Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was identified in late 2019, the coronavirus disease 2019 (COVID-19) pandemic has challenged public health around world. Currently, there is an urgent need to explore antiviral therapeutic targets and effective clinical drugs. In this study, we systematically summarized two main strategies against COVID-19, namely drugs targeting SARS-CoV-2 life cycle SARS-CoV-2-induced inflammation host cells. The development of above implemented by repurposing exploring potential targets. A comprehensive summary promising drugs, especially cytokine inhibitors, traditional Chinese medicine (TCM), provides recommendations for clinicians as evidence-based actual COVID-19 treatment. Considering emerging variants greatly impact effectiveness vaccines, reviewed appearance details further perspectives drug design, which brings updating clues develop therapeutical agents variants. Based on this, broadly combined with immunomodulatory, or holistic therapy host, prior being considered interventions mutant strains SARS-CoV-2. Therefore, it highly acclaimed requirements concerted efforts from multi-disciplinary basic studies trials, improves accurate treatment optimizes contingency measures

Language: Английский

Citations

65
A Comprehensive Review about the Molecular Structure of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Insights into Natural Products against COVID-19 DOI Creative Commons
Essa M. Saied, Yousra A. El‐Maradny, Alaa A. Osman

et al.

Pharmaceutics, Journal Year: 2021, Volume and Issue: 13(11), P. 1759 - 1759

Published: Oct. 21, 2021

In 2019, the world suffered from emergence of COVID-19 infection, one most difficult pandemics in recent history. Millions confirmed deaths this pandemic have been reported worldwide. This disaster was caused by SARS-CoV-2, which is last discovered member family Coronaviridae. Various studies shown that natural compounds effective antiviral properties against coronaviruses inhibiting multiple viral targets, including spike proteins and enzymes. review presents classification a detailed explanation SARS-CoV-2 molecular characteristics structure–function relationships. We present all currently available crystal structures different emphasized on structure virus binding modes their ligands. also discusses various therapeutic approaches for treatment vaccinations. addition, we highlight compare existing data about extracted algae, fungi, plants, scorpion venom were used as agents infection. Moreover, discuss repurposing select approved other viruses.

Language: Английский

Citations

58