Alzheimer’s disease and COVID-19: Interactions, intrinsic linkages, and the role of immunoinflammatory responses in this process DOI Creative Commons
Wei Li,

Lin Sun,

Ling Yue

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 9, 2023

Alzheimer’s disease (AD) and COVID-19 share many common risk factors, such as advanced age, complications, APOE genotype, etc. Epidemiological studies have also confirmed the internal relationship between two diseases. For example, found that AD patients are more likely to suffer from COVID-19, after infection with has a much higher of death than other chronic diseases, what’s interesting is developing in future significantly COVID-19. Therefore, this review gives detailed introduction perspectives epidemiology, susceptibility mortality. At same time, we focused on important role inflammation immune responses promoting onset

Language: Английский

Pyroptosis and respiratory diseases: A review of current knowledge DOI Creative Commons
Jialiang Sun, Yanan Li

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 30, 2022

Pyroptosis is a relatively newly discovered programmed cell death accompanied by an inflammatory response. In the classical view, pyroptosis mediated caspases-1,-4,-5,-11 and executed GSDMD, however, recently it was demonstrated that caspase-3 and-8 also participate in process of pyroptosis, cleaving GSDMD/E GSDMD respectively. Different from autophagy apoptosis, many pores are formed on membrane during which makes lose its integrity, eventually leading to release cytokines interleukin(IL)-1β IL-18. When body infected with pathogens or exposed some stimulations, could play immune defense role. It found exists widely infectious respiratory diseases such as acute lung injury, bronchial dysplasia, chronic obstructive pulmonary disease, asthma. Excessive may accompany airway inflammation, tissue damage, induce reaction, more serious damage poor prognosis diseases. This review summarizes relationship between related

Language: Английский

Citations

48
Coronavirus Infection and Cholesterol Metabolism DOI Creative Commons
Jun Dai, Huan Wang, Ying Liao

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: April 21, 2022

Host cholesterol metabolism remodeling is significantly associated with the spread of human pathogenic coronaviruses, suggesting virus-host relationships could be affected by cholesterol-modifying drugs. Cholesterol has an important role in coronavirus entry, membrane fusion, and pathological syncytia formation, therefore metabolic mechanisms may promising drug targets for infections. Moreover, its metabolizing enzymes or corresponding natural products exert antiviral effects which are closely individual viral steps during replication. Furthermore, disease 2019 (COVID-19) caused severe acute respiratory syndrome 2 infections clinically significant low levels, function as a potential marker monitoring infection status. Therefore, weaponizing dysregulation against effective strategy. In this review, we comprehensively review literature to clarify how coronaviruses exploit host accommodate replication requirements interfere immune responses. We also focus on targeting homeostasis critical infection.

Language: Английский

Citations

47
Recent advances in point of care testing for COVID-19 detection DOI Open Access
Renata Salgado Fernandes, Juliana de Oliveira Silva, Karina Braga Gomes

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 153, P. 113538 - 113538

Published: Aug. 12, 2022

The World Health Organizations declaration of the COVID-19 pandemic was a milestone for scientific community. high transmission rate and huge number deaths, along with lack knowledge about virus evolution disease, stimulated relentless search diagnostic tests, treatments, vaccines. main challenges were differential diagnosis development specific, rapid, sensitive tests that could reach all people. RT-PCR remains gold standard diagnosing COVID-19. However, new methods, such as other molecular techniques immunoassays emerged. Also, need accessible quick results boosted point care (POCT) are fast, automated, precision accuracy. This assay reduces dependence on laboratory conditions mass testing population, dispersing pressure regarding screening detection. review summarizes advances in field since started, emphasizing various detecting We reviewed existing well POCT under development, starting detection, but also exploring nucleic acid techniques, digital PCR, loop-mediated isothermal amplification-based (RT-LAMP), clustered regularly interspaced short palindromic repeats (CRISPR), next-generation sequencing (NGS), immunoassay nanoparticle-based biosensors, developed portable instruments rapid

Language: Английский

Citations

47
PWM2Vec: An Efficient Embedding Approach for Viral Host Specification from Coronavirus Spike Sequences DOI Creative Commons
Sarwan Ali, Babatunde Bello, Prakash Chourasia

et al.

Biology, Journal Year: 2022, Volume and Issue: 11(3), P. 418 - 418

Published: March 9, 2022

The study of host specificity has important connections to the question about origin SARS-CoV-2 in humans which led COVID-19 pandemic-an open question. There are speculations that bats a possible origin. Likewise, there many closely related (corona)viruses, such as SARS, was found be transmitted through civets. different hosts can potential carriers and transmitters deadly viruses is crucial understanding, mitigating, preventing current future pandemics. In coronaviruses, surface (S) protein, or spike determining specificity, since it point contact between virus cell membrane. this paper, we classify over five thousand coronaviruses from their protein sequences, segregating them into clusters distinct among birds, bats, camels, swine, humans, weasels, name few. We propose feature embedding based on well-known position weight matrix (PWM), call PWM2Vec, use generate vectors sequences these coronaviruses. While our inspired by success PWMs biological applications, function identifying transcription factor binding sites, first (to best knowledge) viral fixed-length vector representations, context classification. results real world data show when using machine learning classifiers able perform comparably baseline models terms predictive performance runtime-in some cases, better. also measure importance amino acids information gain for predicting given coronavirus. Finally, statistical analyses more compact than embeddings models.

Language: Английский

Citations

44
Associations between Serum Interleukins (IL-1β, IL-2, IL-4, IL-6, IL-8, and IL-10) and Disease Severity of COVID-19: A Systematic Review and Meta-Analysis DOI Creative Commons
Yuanmin Chang,

Mengru Bai,

Qinghai You

et al.

BioMed Research International, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 15

Published: April 30, 2022

Background. To investigate the association between interleukins (IL-1β, IL-2, IL-4, IL-6, IL-8, and IL-10) disease severity of coronavirus 2019 (COVID-19). Materials Methods. We systematically searched records investigating role in COVID-19 patients Web Science, Pubmed, Embase through December 2020. Data were extracted pooled, weighted mean difference (WMD) its 95% confidence interval (CI) calculated. The funnel plot nonparametric trim fill method used to visualize adjust publication bias. Results. In total, 61 studies enrolled 14,136 subjects (14,041 95 healthy subjects) this meta-analysis. Our results showed that serum IL-10 levels elevated compared controls, increased severe cases nonsevere patients. Additionally, IL-1β, IL-8 nonsurvivor survivors. For intensive care unit (ICU), IL-6 than non-ICU Conclusions. Elevated associated with COVID-19, related prognosis patients, which could be evaluate patients’ prognosis.

Language: Английский

Citations

43
Multi-omics blood atlas reveals unique features of immune and platelet responses to SARS-CoV-2 Omicron breakthrough infection DOI Creative Commons
Hong Wang, Cuicui Liu, Xiaowei Xie

et al.

Immunity, Journal Year: 2023, Volume and Issue: 56(6), P. 1410 - 1428.e8

Published: May 17, 2023

Language: Английский

Citations

30
Fc-Engineered Therapeutic Antibodies: Recent Advances and Future Directions DOI Creative Commons

Dalia T. Abdeldaim,

Katharina Schindowski

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(10), P. 2402 - 2402

Published: Sept. 28, 2023

Monoclonal therapeutic antibodies have revolutionized the treatment of cancer and other diseases. Fc engineering aims to enhance effector functions or half-life by modifying their regions. Recent advances in modern can be considered next generation antibody therapy. Various strategies are employed, including altering glycosylation patterns via glycoengineering introducing mutations region, thereby enhancing receptor complement interactions. Further, enable bispecific IgG-based heterodimeric antibodies. As techniques continue evolve, an expanding portfolio Fc-engineered is advancing through clinical development, with several already approved for medical use. Despite plethora Fc-based that been analyzed vitro vivo models, we focus here this review on relevant finetune functions, modify stabilize asymmetric IgGs.

Language: Английский

Citations

28
The effects and mechanisms of the anti-COVID-19 traditional Chinese medicine, Dehydroandrographolide from Andrographis paniculata (Burm.f.) Wall, on acute lung injury by the inhibition of NLRP3-mediated pyroptosis DOI Creative Commons
Zhichen Pu,

Bangzhi Sui,

Xingwen Wang

et al.

Phytomedicine, Journal Year: 2023, Volume and Issue: 114, P. 154753 - 154753

Published: March 30, 2023

Dehydroandrographolide (Deh) from Andrographis paniculata (Burm.f.) Wall has strong anti-inflammatory and antioxidant activities.To explore the role of Deh in acute lung injury (ALI) coronavirus disease 19 (COVID-19) its inflammatory molecular mechanism.Liposaccharide (LPS) was injected into a C57BL/6 mouse model ALI, LPS + adenosine triphosphate (ATP) used to stimulate BMDMs an vitro ALI.In vivo considerably reduced inflammation oxidative stress by inhibiting NLRP3-mediated pyroptosis attenuated mitochondrial damage suppress through suppression ROS production Akt/Nrf2 pathway. inhibited interaction between Akt at T308 PDPK1 S549 promote protein phosphorylation. directly targeted accelerated ubiquitination. 91-GLY, 111-LYS, 126-TYR, 162-ALA, 205-ASP 223-ASP may be reason for Deh.Deh presented ALI ROS-induced inhibition pathway Therefore, it can concluded that potential therapeutic drug treatment COVID-19 or other respiratory diseases.

Language: Английский

Citations

25
Current trends of clinical trials involving CRISPR/Cas systems DOI Creative Commons
Song‐Yang Zhang, Yidi Wang,

Dezhi Mao

et al.

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: Nov. 10, 2023

The CRISPR/Cas9 system is a powerful genome editing tool that has made enormous impacts on next-generation molecular diagnostics and therapeutics, especially for genetic disorders traditional therapies cannot cure. Currently, CRISPR-based gene widely applied in basic, preclinical, clinical studies. In this review, we attempt to identify trends studies involving CRISPR techniques gain insights into the improvement contribution of CRISPR/Cas technologies compared modified modalities. review trials focused applications systems treatment cancer, hematological, endocrine, immune diseases, as well diagnostics. scientific basis underlined analyzed. addition, challenges application disease recent advances expand improve precision medicine are discussed.

Language: Английский

Citations

25
After the Hurricane: Anti-COVID-19 Drugs Development, Molecular Mechanisms of Action and Future Perspectives DOI Open Access
Hazim O. Khalifa,

Yousef Al Ramahi

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 739 - 739

Published: Jan. 6, 2024

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a new coronavirus in the

Language: Английский

Citations

12