Review on the synergistic mechanisms in harnessing rice residue-derived cellulose nanocrystals for sustainable water purification and wastewater treatment DOI
Bhupinder Singh, Ravinder Kumar, Shubham Sharma

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143225 - 143225

Published: April 1, 2025

Language: Английский

Photodynamic Therapy (PDT) in Drug Delivery: Nano-innovations enhancing treatment outcomes DOI Creative Commons

Ahmed N. Al-Jamal,

Ali Fawzi Al-Hussainy,

Bahira Abdulrazzaq Mohammed

et al.

Health Sciences Review, Journal Year: 2025, Volume and Issue: unknown, P. 100218 - 100218

Published: Jan. 1, 2025

Language: Английский

Citations

1
PROTAC Delivery Strategies for Overcoming Physicochemical Properties and Physiological Barriers in Targeted Protein Degradation DOI Creative Commons

Endry Wahyu Syahputra,

Hyunji Lee, Hyuk Jun Cho

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 501 - 501

Published: April 9, 2025

Proteolysis targeting chimeras (PROTACs), heterobifunctional molecules that hijack the ubiquitin–proteasome system (UPS) to degrade specific proteins, hold great promise in treating diseases driven by traditionally “undruggable” targets. However, their large molecular weight, high hydrophobicity, and other physicochemical hurdles contribute limited bioavailability, suboptimal pharmacokinetics, attenuated therapeutic efficacy. Consequently, diverse formulation innovations have been investigated optimize PROTAC delivery. This review examines current challenges advances specialized drug delivery approaches designed bolster pharmacological performance. We first outline fundamental limitations of PROTACs—their low aqueous solubility, poor cell permeability, rapid clearance, concentration-dependent “hook effect”. then discuss how various enabling formulations address these issues, including polymeric micelles, emulsions, amorphous solid dispersions, lipid-based nanoparticles, liposomes, exosomes. Collectively, technologies substantially improve outcomes PROTACs preclinical cancer models. Future applications may extend beyond oncology complex using newly emerging molecules. By integrating advanced science with innovative degrader design, field stands poised unlock clinical potential for protein degradation therapies.

Language: Английский

Citations

0
Review on the synergistic mechanisms in harnessing rice residue-derived cellulose nanocrystals for sustainable water purification and wastewater treatment DOI
Bhupinder Singh, Ravinder Kumar, Shubham Sharma

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143225 - 143225

Published: April 1, 2025

Language: Английский

Citations

0