Should We Consider Neurodegeneration by Itself or in a Triangulation with Neuroinflammation and Demyelination? The Example of Multiple Sclerosis and Beyond DOI Open Access
Océane Perdaens, Vincent Van Pesch

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12637 - 12637

Published: Nov. 25, 2024

Neurodegeneration is preeminent in many neurological diseases, and still a major burden we fail to manage patient's care. Its pathogenesis complicated, intricate, far from being completely understood. Taking multiple sclerosis as an example, propose that neurodegeneration neither cause nor consequence by itself. Mitochondrial dysfunction, leading energy deficiency ion imbalance, plays key role neurodegeneration, partly caused the oxidative stress generated microglia astrocytes. Nodal paranodal disruption, with or without myelin alteration, further involved. Myelin loss exposes axons directly inflammatory environment. Moreover, oligodendrocytes provide singular metabolic trophic support axons, but do not emerge unscathed pathological events, primary defects cell apoptosis secondary neuroinflammation axonal damage. Hereby, failure might be overlooked contributor neurodegeneration. Thus, complex interplay between neuroinflammation, demyelination, wherein each primarily secondarily involved, offer more comprehensive understanding of help establishing novel therapeutic strategies for diseases beyond.

Language: Английский

Update on Hypothalamic Inflammation and Gliosis: Expanding Evidence of Relevance Beyond Obesity DOI
Alyssa Huang, Dabin Yeum, Letícia E. Sewaybricker

et al.

Current Obesity Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 8, 2025

Language: Английский

Citations

0
Relationship between weight-to-waist index and post-stroke depression DOI
Juan Li,

Lijun Ma,

Xiaoyuan Ma

et al.

World Journal of Psychiatry, Journal Year: 2025, Volume and Issue: 15(3)

Published: Feb. 26, 2025

The weight-to-waist index (WWI) serves as an innovative metric specifically designed to assess central obesity. However, the relationship between WWI and prevalence of post-stroke depression (PSD) remains inadequately explored in literature. To elucidate PSD. Data from National Health Nutrition Examination Survey 2005 2018 were analyzed. Multivariable logistic regression models propensity score matching utilized investigate association PSD, with adjustments for potential confounders. restricted cubic spline statistical method was applied explore non-linear associations. Participants elevated values had a significantly greater risk developing Specifically, individuals higher range exhibited more than twice likelihood PSD compared those lower (odds ratio = 2.21, 95% confidence interval: 1.84-2.66, P < 0.0001). After matching, remained 1.43, 95%confidence 1.09-1.88, 0.01). Tertile analysis revealed that participants highest tertile faced lowest tertile. Restricted further association, plateauing at values. There is significant increased Thus, regular screening should be implemented stroke patients enhance patient outcomes.

Language: Английский

Citations

0
Novel brain biomarkers of obesity in young adult women based on statistical measurements of white matter tracts DOI Creative Commons
José Gerardo Suárez-García, Marine Raquel Diniz da Rosa,

Nora Coral Soriano-Becerril

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0319936 - e0319936

Published: April 10, 2025

Objective Novel brain biomarkers of obesity were sought by studying statistical measurements on fractional anisotropy (FA) images different white matter (WM) tracts from young adult women. Methods Tract chosen that showed differences between two groups (normal weight and overweight/obese) correlated with BMI. From these measurements, a simple novel process was applied to select those would allow the creation models quantify classify state individuals. The created tract used in models. Results Positive correlations found WM integrity BMI, mainly involved motor functions. results, built status, whose regression coefficients formed proposed associated biomarkers. Conclusion A for selection proposed, such determine status subjects individually. models, created. These results generate new knowledge field, intended be future clinical environment as prevention treatment tool changes obesity. Significance After women, opposed some previous reported literature. consisted positive also precise quantification classification status. All this allows generation its probable subsequent application.

Language: Английский

Citations

0
Should We Consider Neurodegeneration by Itself or in a Triangulation with Neuroinflammation and Demyelination? The Example of Multiple Sclerosis and Beyond DOI Open Access
Océane Perdaens, Vincent Van Pesch

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12637 - 12637

Published: Nov. 25, 2024

Neurodegeneration is preeminent in many neurological diseases, and still a major burden we fail to manage patient's care. Its pathogenesis complicated, intricate, far from being completely understood. Taking multiple sclerosis as an example, propose that neurodegeneration neither cause nor consequence by itself. Mitochondrial dysfunction, leading energy deficiency ion imbalance, plays key role neurodegeneration, partly caused the oxidative stress generated microglia astrocytes. Nodal paranodal disruption, with or without myelin alteration, further involved. Myelin loss exposes axons directly inflammatory environment. Moreover, oligodendrocytes provide singular metabolic trophic support axons, but do not emerge unscathed pathological events, primary defects cell apoptosis secondary neuroinflammation axonal damage. Hereby, failure might be overlooked contributor neurodegeneration. Thus, complex interplay between neuroinflammation, demyelination, wherein each primarily secondarily involved, offer more comprehensive understanding of help establishing novel therapeutic strategies for diseases beyond.

Language: Английский

Citations

1