Metabolic syndrome associated with hyperandrogenism in the reproductive age. Hormonal profile in different ethnicities women DOI Creative Commons
M. A. Darenskaya, L. V. Belenkaia, Л. Ф. Шолохов

et al.

Acta Biomedica Scientifica (East Siberian Biomedical Journal), Journal Year: 2024, Volume and Issue: 9(5), P. 150 - 158

Published: Nov. 22, 2024

Background . Metabolic syndrome (MS) with hyperandrogenism comorbidity in women is considered a common concept; however, the contribution of neuroendocrine regulation system indicators to this reproductive age remains unclear.The aim. To analyze activity different ethnic groups metabolic associated hyperandrogenism. Materials and methods The MS Russian (n = 209) Buryat 84) group polycystic ovary (PCOS) 23) 10) were formed. Results In PCOS study noted higher levels anti-Müllerian hormone (AMH) (p 0.030), testosterone (Ts) 0.026), free androgen index (FAI) < 0.0001), dehydroepiandrosterone sulfate (DHEA-S) reduced sex hormone-binding globulin (SHBG) 0.0001) relation control; MS, we discovered increased values AMH 0.001), Ts FAI DHEA-S decreased SHBG 0.001). recorded 0.045), 0.002), 0.033), 0.016) 17-OH-progesterone 0.027) comparison level 0.006) 0.028). Conclusion Women showed more intense changes relative control regardless ethnicity. women, combined (MS PCOS) was accompanied by greater number hormonal compared monosyndrome than women. data obtained indicate need assess content these metabolites PCOS, taking into account

Language: Английский

Recent developments in drug treatment strategies for infertility in patients with polycystic ovary syndrome DOI
Stefano Palomba,

Mario Molinaro,

Alice Ingargiola

et al.

Expert Opinion on Pharmacotherapy, Journal Year: 2024, Volume and Issue: 25(16), P. 2191 - 2202

Published: Oct. 20, 2024

Introduction Infertility related to polycystic ovary syndrome (PCOS) represents a significant challenge for women of reproductive age. Over the last few years, evidence-based medicine has driven new approaches treating infertility in patients with PCOS, changing rapidly and deeply clinical practice.

Language: Английский

Citations

3
The Race for Diagnosis of Polycystic Ovary Syndrome DOI Creative Commons
Geralyn Lambert‐Messerlian

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: July 26, 2024

Journal Article Corrected proof The Race for Diagnosis of Polycystic Ovary Syndrome Get access Geralyn Lambert-Messerlian Department Pathology and Laboratory Medicine, Women Infants Hospital the Alpert Medical School at Brown University, Providence, RI 02903, USADepartment Obstetrics Gynecology, USA Correspondence: Lambert-Messerlian, PhD, 70 Elm Street, 2nd floor, USA. Email: [email protected]. https://orcid.org/0000-0002-9440-3411 Search other works by this author on: Oxford Academic Google Scholar Clinical Endocrinology & Metabolism, dgae495, https://doi.org/10.1210/clinem/dgae495 Published: 26 July 2024 history Received: 09 Editorial decision: 12 typeset:

Language: Английский

Citations

0
Gut microbiota biodiversity indices as markers of hyperandrogenemia in women of reproductive age DOI Creative Commons
I. A. Igumnov, N. L. Belkova, A. V. Atalyan

et al.

Acta Biomedica Scientifica (East Siberian Biomedical Journal), Journal Year: 2024, Volume and Issue: 9(4), P. 12 - 18

Published: Sept. 25, 2024

Introduction. Pr eviously , it was shown that the “classic” phenotypes of polycystic ovarian syndrome (PCOS) are associated with significant decrease in gut microbiota alpha diversity as compared healthy women. The aim study. T o establish cut-off points for indices, hyperandrogenism. Material and methods. he manuscript pr esents a sub-study Eastern Siberia PCOS Epidemiology Phenotype Study, conducted (Russia) from 2016 to 2019. All participants (175 women reproductive age: 26 (according Rotterdam criteria (2003)) hyperandrogenemia (increased levels total testosterone (TT) and/or free androgenindex(FAI), and/ordehydroepiandrosterone sulphate (DHEAS)), 149 – without hyperandrogenemia) were recruited during annual employment medical assessment. Methods included questionnaire survey, anthropometry modified Ferriman Gallwey score, gynecological examination, pelvic ultrasound, blood serum tests TT, DHEAS, sex hormone-binding globulin, FAI, prolactin, thyroid-stimulating hormone, 17-hydroxyprogesterone. Five indices (amplicon sequencing variant, Shannon index, Simpson Chao abundance-based coverage Index) estimated using amplicon metasequencing. Statistical analysis ROC-analysis development hyperandrogenism age PCOS. Results . According t results ROC-analysis, greatest sensitivity moderate specificity, high area under curve established classifying or 5.84 0.97, respectively. Conclusions. developed assessing most can be useful monitoring different therapeutic interventions (prebiotics, probiotics, etc.) hyperandrogenic

Language: Английский

Citations

0
Metabolic syndrome associated with hyperandrogenism in the reproductive age. Hormonal profile in different ethnicities women DOI Creative Commons
M. A. Darenskaya, L. V. Belenkaia, Л. Ф. Шолохов

et al.

Acta Biomedica Scientifica (East Siberian Biomedical Journal), Journal Year: 2024, Volume and Issue: 9(5), P. 150 - 158

Published: Nov. 22, 2024

Background . Metabolic syndrome (MS) with hyperandrogenism comorbidity in women is considered a common concept; however, the contribution of neuroendocrine regulation system indicators to this reproductive age remains unclear.The aim. To analyze activity different ethnic groups metabolic associated hyperandrogenism. Materials and methods The MS Russian (n = 209) Buryat 84) group polycystic ovary (PCOS) 23) 10) were formed. Results In PCOS study noted higher levels anti-Müllerian hormone (AMH) (p 0.030), testosterone (Ts) 0.026), free androgen index (FAI) < 0.0001), dehydroepiandrosterone sulfate (DHEA-S) reduced sex hormone-binding globulin (SHBG) 0.0001) relation control; MS, we discovered increased values AMH 0.001), Ts FAI DHEA-S decreased SHBG 0.001). recorded 0.045), 0.002), 0.033), 0.016) 17-OH-progesterone 0.027) comparison level 0.006) 0.028). Conclusion Women showed more intense changes relative control regardless ethnicity. women, combined (MS PCOS) was accompanied by greater number hormonal compared monosyndrome than women. data obtained indicate need assess content these metabolites PCOS, taking into account

Language: Английский

Citations

0