Bisphenol F-Induced Neurotoxicity toward Zebrafish Embryos

Environmental Science & Technology, Journal Year: 2019, Volume and Issue: 53(24), P. 14638 - 14648

Published: Nov. 8, 2019

In this study, the influence of bisphenol F (BPF) toward central nervous system (CNS) was assessed using zebrafish embryos. We found that BPF could induce significant neurotoxicity embryos, including inhibited locomotion, reduced moving distance, and CNS cell apoptosis at an effective concentration 0.0005 mg/L. Immunofluorescence assay showed both microglia astrocyte in brain were significantly activated by BPF, indicating existence neuroinflammatory response. Peripheral motor neuron development 72 hpf. RNA-seq data indicated neuronal developmental processes pathways affected exposure, which consistent with phenotypic results. Chip-seq implied transcriptional changes not mediated ERα. Additionally, no change neurotransmitter levels (5-hydroxytryptamine, dopamine, acetylcholine) or acetylcholinesterase (Ache) enzyme activity after may affect neurotransmission. conclusion, lead to abnormal neural outcomes during early life stage through inducing neuroinflammation even environmentally relevant concentration.

Language: Английский

---

Neuroendocrine disruption in animal models due to exposure to bisphenol A analogues

Frontiers in Neuroendocrinology, Journal Year: 2017, Volume and Issue: 47, P. 123 - 133

Published: Aug. 8, 2017

Language: Английский

---

Oxidative stress and immune disturbance after long-term exposure to bisphenol A in juvenile common carp (Cyprinus carpio)

Ecotoxicology and Environmental Safety, Journal Year: 2016, Volume and Issue: 130, P. 93 - 102

Published: April 16, 2016

Language: Английский

---

Prenatal Exposure to Bisphenol A Analogues on Male Reproductive Functions in Mice

Toxicological Sciences, Journal Year: 2018, Volume and Issue: 163(2), P. 620 - 631

Published: March 20, 2018

This study was performed to examine whether prenatal exposure bisphenol (BP) A analogues, BPE and BPS, negatively impacts male reproductive functions testis development using mice as a model. CD-1 were orally exposed control treatment (corn oil), BPA, BPE, BPS (0.5, 20, or 50 µg/kg/day) from gestational day 11 (the presence of vaginal plug = 1) birth. Although sperm counts significantly reduced by on postnatal (PND) 60, only remained low for motility. Exposure disrupted the progression germ cell development, morphometric analyses exhibited an abnormal distribution stages spermatogenesis. Furthermore, with dose µg/kg/day increased level serum estradiol-17β in adult males. On PND12, TUNEL positive cells neonatal testis, following disruption expression apoptosis, autophagy, oxidative stress-related factors. In addition, methyltransferases DNA methylation histone modification also affected testis. These results suggest that physiologically relevant doses affects probably due spermatogenic defect developing

Language: Английский

---

Prenatal exposure to bisphenol A and its alternatives and child neurodevelopment at 2 years

Journal of Hazardous Materials, Journal Year: 2019, Volume and Issue: 388, P. 121774 - 121774

Published: Nov. 28, 2019

Language: Английский

---