Frontiers in Endocrinology,
Journal Year:
2023,
Volume and Issue:
14
Published: May 23, 2023
Metabolic
syndrome
is
a
complex
metabolic
disorder,
its
main
clinical
manifestations
are
obesity,
hyperglycemia,
hypertension
and
hyperlipidemia.
Although
has
been
the
focus
of
research
in
recent
decades,
it
proposed
that
occurrence
development
related
to
pathophysiological
processes
such
as
insulin
resistance,
adipose
tissue
dysfunction
chronic
inflammation,
but
there
still
lack
favorable
prevention
treatment
measures
for
syndrome.
Multiple
studies
have
shown
myostatin
(MSTN),
member
TGF-β
family,
involved
hyperlipidemia,
diabetes,
(clinical
syndrome),
thus
may
be
potential
therapeutic
target
In
this
review,
we
describe
transcriptional
regulation
receptor
binding
pathway
MSTN,
then
introduce
role
MSTN
regulating
mitochondrial
function
autophagy,
review
progress
Finally
summarize
some
inhibitors
under
trial
use
inhibitor
Bone Research,
Journal Year:
2025,
Volume and Issue:
13(1)
Published: Feb. 25, 2025
Abstract
The
muscular
system
plays
a
critical
role
in
the
human
body
by
governing
skeletal
movement,
cardiovascular
function,
and
activities
of
digestive
organs.
Additionally,
muscle
tissues
serve
an
endocrine
function
secreting
myogenic
cytokines,
thereby
regulating
metabolism
throughout
entire
body.
Maintaining
requires
iron
homeostasis.
Recent
studies
suggest
that
disruptions
ferroptosis,
form
iron-dependent
cell
death,
are
essential
contributors
to
progression
wide
range
diseases
disorders,
including
sarcopenia,
cardiomyopathy,
amyotrophic
lateral
sclerosis.
Thus,
comprehensive
overview
mechanisms
ferroptosis
these
conditions
is
crucial
for
identifying
potential
therapeutic
targets
developing
new
strategies
disease
treatment
and/or
prevention.
This
review
aims
summarize
recent
advances
understanding
molecular
underlying
context
injury,
as
well
associated
disorders.
Moreover,
we
discuss
within
pathway
possible
managing
Finally,
shed
light
on
current
limitations
future
prospects
interventions
targeting
ferroptosis.
Autophagy,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 10, 2025
Mitochondrial
quality
control
is
critical
in
muscle
to
ensure
contractile
and
metabolic
function.
BNIP3L/Nix
a
BCL2
member,
mitophagy
receptor,
has
been
implicated
atrophy.
Human
genome-wide
association
studies
(GWAS)
suggest
altered
BNIP3L
expression
could
predispose
mitochondrial
disease.
To
investigate
function,
we
generated
muscle-specific
knockout
model.
bnip3l
mice
displayed
ragged-red
fiber
phenotype,
along
with
accumulation
of
mitochondria
endo/sarcoplasmic
reticulum
morphology.
Intriguingly,
were
more
insulin
sensitive
corresponding
increase
glycogen-rich
fibers.
Kinome
gene
analyses
revealed
that
impairs
NFAT
MSTN
(myostatin)
signaling,
alterations
fiber-type
evidence
regeneration.
Mechanistic
experiments
demonstrated
modulates
mitophagy,
reticulophagy
leading
nuclear
calcium
signaling.
Collectively,
these
observations
identify
novel
roles
for
coordinating
selective
autophagy,
oxidative
expression,
signaling
pathways
maintain
the
phenotype.
Medicina,
Journal Year:
2025,
Volume and Issue:
61(4), P. 551 - 551
Published: March 21, 2025
Background
and
Objectives:
Sarcopenia
is
a
notable
comorbidity
of
rheumatoid
arthritis
(RA),
affecting
about
one
third
patients.
However,
the
characteristic
muscle
function
its
association
with
RA
disease
remains
unknown.
Materials
Methods:
This
cross-sectional
study
collected
clinical
data
from
real-world
Chinese
cohort.
was
defined
as
both
myopenia
low
(LMF).
Myopenia
appendicular
skeletal
mass
index
(ASMI)
<
7.0
kg/m2
in
men
<5.7
women.
LMF
strength
(LMS,
hand
grip
28
kg
<18
women)
or
physical
performance
(LPP,
6
m
gait
speed
1.0
m/s).
Results:
Among
1125
patients
recruited
this
study,
928
were
eligible
for
analysis.
The
prevalence
sarcopenia,
myopenia,
LMF,
LMS,
LPP
all
36.5%,
46.1%,
69.0%,
57.8%,
37.1%,
respectively.
According
to
their
trends
age
activity,
there
111
(11.9%)
young
(age
50
years)
remission
(CDAI
≤
2.8)
subgroup,
199
(21.4%)
active
>
198
(21.3%)
old
≥
420
(45.2%)
subgroup.
Compared
two
subgroups,
respectively,
subgroup
had
significantly
lower
strength,
higher
worse
activity
function.
After
adjustment
potential
confounders,
multivariate
multinominal
logistic
regression
analysis
showed
that
positively
associated
sarcopenia
(OR
=
3.193,
95%CI:
1.477–6.899),
2.390,
1.207–4.731),
LMS
3.520,
1.743–7.110).
Conclusions:
Worse
rather
than
reduced
performance,
more
common
at
age.
It
underscores
critical
need
early
identification
intervention
dysfunction
improve
quality
life.
Frontiers in Endocrinology,
Journal Year:
2023,
Volume and Issue:
14
Published: May 23, 2023
Metabolic
syndrome
is
a
complex
metabolic
disorder,
its
main
clinical
manifestations
are
obesity,
hyperglycemia,
hypertension
and
hyperlipidemia.
Although
has
been
the
focus
of
research
in
recent
decades,
it
proposed
that
occurrence
development
related
to
pathophysiological
processes
such
as
insulin
resistance,
adipose
tissue
dysfunction
chronic
inflammation,
but
there
still
lack
favorable
prevention
treatment
measures
for
syndrome.
Multiple
studies
have
shown
myostatin
(MSTN),
member
TGF-β
family,
involved
hyperlipidemia,
diabetes,
(clinical
syndrome),
thus
may
be
potential
therapeutic
target
In
this
review,
we
describe
transcriptional
regulation
receptor
binding
pathway
MSTN,
then
introduce
role
MSTN
regulating
mitochondrial
function
autophagy,
review
progress
Finally
summarize
some
inhibitors
under
trial
use
inhibitor
