NAD+controls circadian rhythmicity during cardiac aging DOI Creative Commons
Bryce J. Carpenter, Margaux Lecacheur,

Yannick N. Mangold

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 5, 2023

Abstract Disruption of the circadian clock as well reduced NAD + levels are both hallmarks aging. While rhythms and metabolism have been linked in heart disease, their relationship during cardiac aging is less clear. Here, we show that leads to disruption diurnal gene expression heart. Long-term supplementation with precursor nicotinamide riboside (NR) boosts levels, reprograms transcriptome reverses naturally occurring enlargement aged female mice. In addition, complete abolishment CMs impairs PER2::luc oscillations, which rescued by NR supplementation. These findings reveal an essential role for regulation upon aging, opens up new avenues counteract age-related disorders.

Language: Английский

Preventing the Fatty Acid-Transporter CD36 From Taking its Toll on the Heart DOI
Mathias Mericskay

Circulation Research, Journal Year: 2024, Volume and Issue: 134(5), P. 526 - 528

Published: Feb. 29, 2024

Language: Английский

Citations

0
The role of nicotinamide adenine dinucleotide salvage enzymes in cardioprotection DOI Creative Commons

Fazle Kibria,

Sudip Das,

Md Sahidul Arefin

et al.

Polish Journal of Cardio-Thoracic Surgery, Journal Year: 2024, Volume and Issue: 21(2), P. 86 - 95

Published: Jan. 1, 2024

AMA Kibria F, Das S, Arefin M. The role of nicotinamide adenine dinucleotide salvage enzymes in cardioprotection. Kardiochirurgia i Torakochirurgia Polska/Polish Journal Thoracic and Cardiovascular Surgery. 2024;21(2):86-95. doi:10.5114/kitp.2024.141145. APA Kibria, F., Das, S., & Arefin, (2024). Surgery, 21(2), 86-95. https://doi.org/10.5114/kitp.2024.141145 Chicago Fazle, Sudip Kumar Md Sahidul Arefin. 2024. "The cardioprotection". Surgery 21 (2): Harvard pp.86-95. MLA Fazle et al. cardioprotection." vol. 21, no. 2, 2024, pp. Vancouver

Language: Английский

Citations

0
Effects of Supplementation with NAD+ Precursors on Metabolic Syndrome Parameters: A Systematic Review and Meta-Analysis DOI

Amanda Oliveira-Cruz,

Alessa Macedo-Silva,

Débora Silva-Lima

et al.

Hormone and Metabolic Research, Journal Year: 2024, Volume and Issue: 56(11), P. 818 - 826

Published: Aug. 7, 2024

Abstract Intracellular levels of NAD + regulate metabolism, among other ways, through enzymes that use as a substrate, capable inducing catabolic processes, such lipid oxidation, glucose uptake, and mitochondrial activity. In several model organisms, administering precursor compounds for synthesis increases its levels, improves homeostasis, reduces weight gain. However, evidence the effects these precursors on human patients needs to be better evaluated. Therefore, we carried out systematic review meta-analysis randomized clinical trials assessed Metabolic Syndrome parameters in humans. We based our methods PRISMA 2020. Our search retrieved 429 articles, 19 controlled were included meta-analysis. risk bias with Rob 2 algorithm summarized quality GRADE algorithm. Supplementation reduced plasma total cholesterol triglycerides volunteers, but intervention did not significantly affect outcomes analyzed. Three articles presented high bias. The varied between very low due bias, imprecision, indirectness. number participants than lipidemia is still generally tiny; therefore, more evaluating will increase evidence. On hand, studies are essential assess lipidemia.

Language: Английский

Citations

0
Dysregulated nicotinamide adenine dinucleotide metabolome in patients hospitalized with COVID‐19 DOI Creative Commons
Rodrigo J. Valderrábano, Benjamin Wipper, Karol M. Pencina

et al.

Aging Cell, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Abstract Nicotinamide adenine dinucleotide (NAD + ) depletion has been postulated as a contributor to the severity of COVID‐19; however, no study prospectively characterized NAD and its metabolites in relation disease patients with COVID‐19. We measured 56 hospitalized COVID‐19 two control groups without COVID‐19: (1) 31 age‐ sex‐matched adults comorbidities, (2) 30 comorbidities. Blood concentrations group were only slightly lower than ( p < 0.05); plasma 1‐methylnicotinamide significantly higher (439.7 ng/mL, 95% CI: 234.0, 645.4 ng/mL) controls (44.5 15.6, 73.4) healthy (18.1 CI 15.4, 20.8; 0.001 for each comparison). Plasma nicotinamide also comorbidities group. 2‐methyl‐2‐pyridone‐5‐carboxamide (2‐PY), but not , associated increased risk death (HR = 3.65; 1.09, 12.2; 0.036) escalation level care 2.90, 1.01, 8.38, 0.049). RNAseq RTqPCR analyses PBMC mRNA found upregulation multiple genes involved synthesis well degradation, dysregulation ‐dependent processes including immune response, DNA repair, metabolism, apoptosis/autophagy, redox reactions, mitochondrial function. are modestly reduced turnover is substantially both biosynthesis supporting rationale NAD+ augmentation attenuate severity.

Language: Английский

Citations

0
NAD+controls circadian rhythmicity during cardiac aging DOI Creative Commons
Bryce J. Carpenter, Margaux Lecacheur,

Yannick N. Mangold

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 5, 2023

Abstract Disruption of the circadian clock as well reduced NAD + levels are both hallmarks aging. While rhythms and metabolism have been linked in heart disease, their relationship during cardiac aging is less clear. Here, we show that leads to disruption diurnal gene expression heart. Long-term supplementation with precursor nicotinamide riboside (NR) boosts levels, reprograms transcriptome reverses naturally occurring enlargement aged female mice. In addition, complete abolishment CMs impairs PER2::luc oscillations, which rescued by NR supplementation. These findings reveal an essential role for regulation upon aging, opens up new avenues counteract age-related disorders.

Language: Английский

Citations

1