The FASEB Journal,
Journal Year:
2025,
Volume and Issue:
39(5)
Published: March 1, 2025
Abstract
Endometriosis,
characterized
by
the
growth
of
uterine‐like
tissue
outside
uterus,
causes
chronic
pain
and
infertility.
Current
diagnostic
therapeutic
strategies
have
notable
limitations,
including
delayed
diagnosis
adverse
effects.
The
transcription
factor
forkhead
box
A2
(FOXA2),
which
is
exclusively
expressed
in
uterine
glandular
epithelium,
regulates
key
genes
involved
endometrial
proliferation,
differentiation,
fertility,
hormone
response.
While
FOXA2
expression
reduced
women
with
endometriosis,
its
pathophysiological
role
disease
not
well
understood.
In
this
study,
we
report
that
endometriosis
significantly
eutopic
endometrium
mice
compared
to
sham
controls,
accompanied
decreased
downstream
gene,
CXCL15.
To
evaluate
effect
loss
surgically
induced
transplanting
control
Rosa26
mTmG/+
or
Pgr
cre/+
Foxa2
f/f
(
d/d
)
into
peritoneal
cavity
mice.
number
weight
ectopic
lesions
were
increased
controls.
Furthermore,
progesterone
receptor
was
epithelium
from
lesions.
Importantly,
treatment
leukemia
inhibitory
(LIF),
a
cytokine
regulated
FOXA2,
lesion
formation
vehicle‐treated
This
study
demonstrates
results
an
increase
incidence
LIF
offers
novel
promising
approach
for
endometriosis.
Molecular Medicine,
Journal Year:
2025,
Volume and Issue:
31(1)
Published: April 27, 2025
Abstract
Background
Endometriosis
can
lead
to
decreased
endometrial
receptivity,
reduced
rates
of
implantation,
and
diminished
ovarian
reserve.
Currently,
more
than
50%
infertile
women
are
found
suffer
from
endometriosis.
However
the
etiology
pathogenesis
endometriosis
still
poorly
understood.
Epithelial-mesenchymal
transition
(EMT)
has
been
confirmed
be
involved
in
PYK2
is
a
non-receptor
tyrosine
kinase
that
affects
cell
proliferation,
survival,
migration
by
regulating
intracellular
signaling
pathways.
plays
regulatory
role
EMT
process
affecting
expression
genes
associated
with
through
influence
transcription
factors.
Snail1
(Snail1)
key
highly
expressed
tissues.
On
other
hand,
invasive
metastatic
ability
cells
mainly
process.
However,
upstream
mechanisms
regulate
protein
stability
not
clear.
Methods
We
identified
kinase,
proline-rich
2
(PYK2
or
PTK2B),
examined
The
relevant
plasmids
were
constructed.
This
study
enrolled
20
patients
laparoscopically
meeting
ASRM
diagnostic
criteria,
collecting
ectopic
lesions
(14
endometriotic
cysts
6
deep
infiltrating
nodules)
along
matched
eutopic
tissues
(15
proliferative
phase,
5
secretory
phase)
as
controls.
All
tissue
specimens
underwent
immunohistochemical
analysis.
Human
stromal
(HESC)
isolated
normal
endometrium
3
control
for
vitro
meconium
induction.
Ectopic
(EESC)
obtained
lesions.
Protein
extracts
both
subjected
Western
blot
co-immunoprecipitation
(Co-IP)
interaction
validation.
Functional
assays
(proliferation/migration/invasion)
performed
using
EESC
11Z
lines
triplicate
biological
replicates.
Co-IP
experiments
verify
between
Snail1,
well
determine
specific
location
this
interaction.
Additionally,
we
effect
on
whether
VS-6063
inhibits
functions
cells.
models
established
five-week-old
female
C57BL/6
mice,
randomly
allocated
into
experimental
(
n
=
10)
groups.
Statistical
analyses
conducted
GraphPad
Prism
7.0,
employing
parametric
tests
normally
distributed
data
non-parametric
methods
otherwise,
Benjamini-Hochberg
correction
multiple
comparisons.
Results
It
acts
new
binding
partner
enhances
increasing
phosphorylation
Snail1.
promotes
migration,
invasion
while
inhibiting
decidualization.
demonstrated
inhibited
vitro,
growth
vivo.
Conclusions
novel
occurrence
development
up-regulating
which
could
promising
therapeutic
target
Journal of Obstetrics and Gynaecology Research,
Journal Year:
2024,
Volume and Issue:
50(10), P. 1771 - 1784
Published: Sept. 18, 2024
Abstract
Aim
Endometriosis
is
a
complex,
multifactorial
disease.
Recent
advances
in
molecular
biology
underscore
that
somatic
mutations
within
the
epithelial
component
of
normal
endometrium,
alongside
aberrant
epigenetic
alterations
endometrial
stromal
cells,
may
serve
as
stimulators
for
proliferation
endometriotic
tissue
peritoneal
cavity.
Nevertheless,
pivotal
inquiries
persist:
deterministic
factors
driving
endometriosis
development
certain
women
while
sparing
others,
notwithstanding
comparable
experiences
retrograde
menstruation.
Within
this
review,
we
endeavor
to
synopsize
current
understanding
diverse
pathophysiologic
mechanisms
underlying
initiation
and
progression
delineate
avenues
future
research.
Methods
A
literature
search
without
time
restriction
was
conducted
utilizing
PubMed
Google
Scholar.
Results
Given
clonal
expansion
stemming
from
cancer‐associated
common
tissue,
only
cells
harboring
imparting
proliferative
advantages
be
selected
survival
outside
uterus.
Endometriotic
capable
engendering
metabolic
plasticity
modulating
mitochondrial
dynamics,
thereby
orchestrating
responses
hypoxia,
oxidative
stress,
inflammation,
hormonal
stimuli,
immune
surveillance,
adeptly
acclimating
their
harsh
surroundings,
stand
chance
at
viability.
Conclusion
The
genesis
appears
reflect
evolutionary
principles
mutation,
selection,
expansion,
adaptation
environment.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(13), P. 6852 - 6852
Published: June 22, 2024
Unexplained
euploid
embryo
transfer
failure
(UEETF)
is
a
frustrating
and
unanswered
conundrum
accounting
for
30
to
50%
of
failures
in
vitro
fertilization
using
preimplantation
genetic
testing
aneuploidy
(PGT-A).
Endometriosis
thought
by
many
account
most
such
losses
menstrual
suppression
or
surgery
prior
the
next
has
been
reported
be
beneficial.
In
this
study,
we
performed
endometrial
biopsy
subset
women
with
UEETF,
oncogene
BCL6
histone
deacetylase
SIRT1.
We
compared
205
PGT-A
cycles
outcomes
provide
those
results
following
treatment
GnRH
agonist
versus
controls
(no
treatment).
Based
on
these
previous
promising
results,
pilot
randomized
controlled
trial
comparing
orally
active
antagonist,
elagolix,
oral
contraceptive
pill
(OCP)
2
months
before
transfer,
monitored
inflammation
miRNA
expression
blood,
after
treatment.
These
studies
support
role
endometriosis
UEETF
suggest
that
medical
suspected
disease
antagonist
could
improve
success
rates
address
underlying
inflammatory
epigenetic
changes
associated
UEETF.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2024,
Volume and Issue:
14
Published: Oct. 31, 2024
Endometriosis
(EMT)
has
a
significant
impact
on
women's
physical
and
mental
health.
In
this
study,
high-throughput
sequencing
technology
was
employed
to
detect
differences
in
gut
microbiota
between
EMT
patients
healthy
individuals
(CTL).
Additionally,
Spearman
correlation
analysis
utilized
analyze
the
different
bacterial
genera
biomarkers
(CA125
CA199).
The
results
demonstrated
that
at
phylum
level,
relative
abundances
of
Proteobacteria
Desulfobacterota_G_459546
group
were
significantly
higher
than
those
CTL
group,
while
Bacteroidota
Firmicutes_A
lower
group.
At
genus
