Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss

The Lancet, Journal Year: 2021, Volume and Issue: 397(10285), P. 1658 - 1667

Published: April 27, 2021

Language: Английский

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Rethinking mechanisms, diagnosis and management of endometriosis

Nature Reviews Endocrinology, Journal Year: 2019, Volume and Issue: 15(11), P. 666 - 682

Published: Sept. 5, 2019

Language: Английский

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The origin and evolution of cell types

Nature Reviews Genetics, Journal Year: 2016, Volume and Issue: 17(12), P. 744 - 757

Published: Nov. 7, 2016

Language: Английский

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Why is placentation abnormal in preeclampsia?

American Journal of Obstetrics and Gynecology, Journal Year: 2015, Volume and Issue: 213(4), P. S115 - S122

Published: Sept. 29, 2015

Language: Английский

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Development of the human placenta

Development, Journal Year: 2019, Volume and Issue: 146(22)

Published: Nov. 15, 2019

ABSTRACT The placenta is essential for normal in utero development mammals. In humans, defective placental formation underpins common pregnancy disorders such as pre-eclampsia and fetal growth restriction. great variation types across mammals means that animal models have been of limited use understanding human development. However, new tools studying development, including 3D organoids, stem cell culture systems single RNA sequencing, brought insights into this field. Here, we review the morphological, molecular functional aspects formation, with a focus on defining – trophoblast.

Language: Английский

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Recurrent pregnancy loss

Nature Reviews Disease Primers, Journal Year: 2020, Volume and Issue: 6(1)

Published: Dec. 10, 2020

Language: Английский

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Physiology of the Endometrium and Regulation of Menstruation

Physiological Reviews, Journal Year: 2020, Volume and Issue: 100(3), P. 1149 - 1179

Published: Feb. 7, 2020

The physiological functions of the uterine endometrium (uterine lining) are preparation for implantation, maintenance pregnancy if implantation occurs, and menstruation in absence pregnancy. thus plays a pivotal role reproduction continuation our species. Menstruation is steroid-regulated event, there alternatives progesterone-primed endometrium, i.e., or menstruation. Progesterone withdrawal trigger menstruating example an injured “wounded” surface that required to rapidly repair each month. events endometrial provide accessible vivo human model inflammation tissue repair. Progress understanding pathophysiology has been facilitated by modern cellular molecular discovery tools, along with animal models simulated menses. Abnormal bleeding (AUB), including heavy menstrual (HMB), imposes massive burden on society, affecting one four women reproductive age. Understanding structural nonstructural causes underpinning AUB essential optimize precision patient management. This careful classification bleeding. We highlight crucial need mechanisms its aberrations. prime target selective progesterone receptor modulators (SPRMs). class compounds therapeutic potential clinical unmet HMB. SPRMs reduce still largely unknown. Human remains taboo topic, many questions concerning physiology pertain yet be answered.

Language: Английский

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A single-cell survey of the human first-trimester placenta and decidua

Science Advances, Journal Year: 2018, Volume and Issue: 4(10)

Published: Oct. 5, 2018

Single-cell transcriptomics reveal cellular diversity in the human first-trimester placenta and decidua.

Language: Английский

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Menstruation: science and society

American Journal of Obstetrics and Gynecology, Journal Year: 2020, Volume and Issue: 223(5), P. 624 - 664

Published: July 21, 2020

Women's health concerns are generally underrepresented in basic and translational research, but reproductive particular has been hampered by a lack of understanding uterine menstrual physiology. Menstrual is an integral part overall because between menarche menopause, most women menstruate. Yet for tens millions around the world, menstruation regularly often catastrophically disrupts their physical, mental, social well-being. Enhancing our underlying phenomena involved menstruation, abnormal bleeding, other menstruation-related disorders will move us closer to goal personalized care. Furthermore, deeper mechanistic menstruation-a fast, scarless healing process healthy individuals-will likely yield insights into myriad diseases involving regulation vascular function locally systemically. We also recognize that many now delay pregnancy there increasing desire fertility preservation. In September 2018, Gynecologic Health Disease Branch Eunice Kennedy Shriver National Institute Child Human Development convened 2-day meeting, "Menstruation: Science Society" with aim "identify gaps opportunities science raise awareness need more research this field." Experts fields ranging from evolutionary role endometrial biology (including omic analysis endometrium, stem cells tissue engineering microbiome, bleeding fibroids) medicine (imaging sampling modalities, patient-focused including smart technologies or applications mobile platforms) societal challenges literacy dissemination frameworks across different economic cultural landscapes shared current state-of-the-art future vision, incorporating patient voice at launch meeting. Here, we provide enhanced meeting report extensive up-to-date (as submission) context, capturing spectrum how processes commence response progesterone withdrawal, through tissue-resident circulating progenitor monthly regeneration-and knowledge on dysregulation leads such as adenomyosis, endometriosis, fibroids-to clinical diagnostics, treatment, education. conclude overview global agenda concerning specifically hygiene, gaining momentum, investment addressing barriers facing girls schools low- middle-income countries recent "menstrual equity" "period poverty" movements spreading high-income countries.

Language: Английский

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Regulation of Placental Extravillous Trophoblasts by the Maternal Uterine Environment

Frontiers in Immunology, Journal Year: 2018, Volume and Issue: 9

Published: Nov. 13, 2018

During placentation invasive extravillous trophoblasts (EVTs) migrate into the maternal uterus and modify its vessels. In particular, remodelling of spiral arteries by EVTs is critical for adapting blood flow nutrient transport to developing fetus. Failures in this process have been noticed different pregnancy complications such as preeclampsia, intrauterine growth restriction, stillbirth or recurrent abortion. Upon invasion decidua, endometrium pregnancy, encounter cell types decidual macrophages, uterine NK (uNK) cells stromal expressing a plethora factors cytokines. Here, we will summarise development EVT lineage, occurring independently environment, formation subtypes. Further, discuss interactions with arteries, veins lymphatics illustrate how decidua immune regulate differentiation, survival. The present literature suggests that environment soluble critically modulate function reproductive success.

Language: Английский

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